360 research outputs found

    Indoor/Outdoor Air Quality Assessment at School near the Steel Plant in Taranto (Italy)

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    This study aims to investigate the air quality in primary school placed in district of Taranto (south of Italy), an area of high environmental risk because of closeness between large industrial complex and urban settlement. The chemical characterization of PM2.5 was performed to identify origin of pollutants detected inside school and the comparison between indoor and outdoor levels of PAHs and metals allowed evaluating intrusion of outdoor pollutants or the existence of specific indoor sources. The results showed that the indoor and outdoor levels of PM2.5, BaP, Cd, Ni, As, and Pb never exceeded the target values issued by World Health Organization (WHO). Nevertheless, high metals and PAHs concentrations were detected especially when school were downwind to the steel plant. TheI/Oratio showed the impact of outdoor pollutants, especially of industrial markers as Fe, Mn, Zn, and Pb, on indoor air quality. This result was confirmed by values of diagnostic ratio as B(a)P/B(g)P, IP/(IP + BgP), BaP/Chry, and BaP/(BaP + Chry), which showed range characteristics of coke and coal combustion. However, Ni and As showedI/Oratio of 2.5 and 1.4, respectively, suggesting the presence of indoor sources

    Vasospastic angina and scombroid syndrome: a case report

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    Scombroid syndrome is a fish poisoning characterised by the onset of symptoms compatible with a pseudoallergic reaction; it is rarely also responsible of signs and symptoms of acute coronary syndromes, as demonstrated in this case repor

    Prognostic role of aldosterone in patients with acute coronary syndrome: short and medium term follow-up.

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    AIMS: Different studies have shown a correlation between aldosterone, atherosclerosis and ischemia in the past decade. Evidence exists for the relationship between high levels of aldosterone and augmented risk of cardiovascular diseases, such as hypertension, cardiac failure, coronary artery disease and stroke. The objective of this study was to determine the prognostic role of aldosterone in patients with myocardial infarction. METHODS:The study population included 96 consecutive patients admitted to our department for ST-elevated and non-ST-elevated myocardial infarction from June 2009 to March 2012. Plasma aldosterone levels were measured at admission to hospital in all patients. A 2-year prospective follow-up was performed, and fatal events and non-fatal events, such as reinfarction, congestive heart failure and arrhythmias, were recorded. RESULTS:Aldosterone levels at admission were associated with incidence of congestive heart failure (P\u200a=\u200a0.02), ventricular arrhythmias (P\u200a=\u200a0.01) and all complications (P\u200a=\u200a0.003) after 1-month follow-up. Moreover, high aldosterone levels gave important information in the medium term (24\u200a\ub1\u200a6 months). Specifically, aldosterone was a predictive variable of reinfarction (P\u200a<\u200a0.0001), congestive heart failure (P\u200a<\u200a0.0001) and adverse events (P\u200a=\u200a0.0002). The logistic regression analysis confirmed these results and showed that aldosterone may be predictive of adverse events at medium-term follow-up (odds ratio 1.1, 95% confidence interval 1.03-1.15, P\u200a=\u200a0.02). CONCLUSION:These data show a strong and significant correlation between plasma aldosterone levels at admission for myocardial infarction and fatal and nonfatal adverse events. Aldosterone appears to be a main marker of adverse clinical outcome, in accordance with the literature. These data suggest the need to identify whether antialdosteronic drug treatment, applied acutely in patients with aldosterone elevation, can influence favorably the prognosis of patients with myocardial infarction

    An evaluation of coronary atherosclerosis using coronary CT in subjects with asymptomatic carotid lesions.

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    The evaluation of coronary lesions in patients with asymptomatic carotid plaque represents a very promising line of research to assess cardiovascular risk and the possible implementation of a more aggressive prevention therapy. METHODS: In this study we enrolled 102 patients with intermediate to high cardiovascular risk but no history of coronary artery disease. The first group, consisting of 51 patients, underwent a Coronary CT scan (CCT-group) as well as carotid ultrasonography. The second group, also consisting of 51 patients, underwent coronary angiography (CA) and carotid ultrasonography. RESULTS: The absence of a statistically significant difference between the involvement of both coronary and carotid sites, assessed by CCT and CA, confirms the role of coronary CT as a useful method in the preclinical evaluation of cardiovascular risk. In the CCT group, the correlation between atherosclerosis of carotid artery and coronary disease, as well as between the mean carotid intimal medial thickness and the number of involved coronary vessels, and between the maximum values of carotid plaque and the presence of coronary artery stenosis > 50%, were statistically significant. The Agatson calcium score was also statistically associated with carotid plaque size. CONCLUSION: The imaging biomarkers have a key role in the evaluation of subclinical atherosclerotic disease. Moreover, carotid ultrasound examination and a CT-scan of coronary arteries, in a particular sub-group of patients with intermediate to high cardiovascular risk, can play a crucial role to assess the preventive therapeutic strategies
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