137 research outputs found
Proudly moving forward and feeling connected: Adolescentsâ daily temporal comparisons relate to a desire for growth and sense of relatedness
Adolescents often compare themselves favorably to others. Although such downward social comparisons make adolescents feel proud, they entail the risk of focusing adolescents on outperforming others rather than on improving themselves. This daily diary study (N = 389 adolescents, ages 11â15) tested the hypothesis that downward temporal comparisonsâcomparing oneâs present self favorably to oneâs past self, rather than to othersâmay elicit pride while encouraging adolescents to strive for self-improvement rather than superiority. Such a desire for self-improvement may, in turn, cultivate a sense of relatedness. Results show that daily downward and upward comparisons co-occurred with pride and shame, respectively, regardless of whether those comparisons were social or temporal. Importantly, daily downward temporal comparisons (unlike daily downward social comparisons) co-occurred with a desire for self-improvement over superiority as well as with a sense of relatedness. This desire for self-improvement over superiority partially mediated the association between downward temporal comparison and a sense of relatedness. Together, these findings underline the role of social and temporal comparisons in self-conscious emotions and goal pursuit and suggest that temporal comparisonsâunlike social comparisonsâmay help adolescents strive for personal growth and build satisfying relationships
The Conley Conjecture and Beyond
This is (mainly) a survey of recent results on the problem of the existence
of infinitely many periodic orbits for Hamiltonian diffeomorphisms and Reeb
flows. We focus on the Conley conjecture, proved for a broad class of closed
symplectic manifolds, asserting that under some natural conditions on the
manifold every Hamiltonian diffeomorphism has infinitely many (simple) periodic
orbits. We discuss in detail the established cases of the conjecture and
related results including an analog of the conjecture for Reeb flows, the cases
where the conjecture is known to fail, the question of the generic existence of
infinitely many periodic orbits, and local geometrical conditions that force
the existence of infinitely many periodic orbits. We also show how a recently
established variant of the Conley conjecture for Reeb flows can be applied to
prove the existence of infinitely many periodic orbits of a low-energy charge
in a non-vanishing magnetic field on a surface other than a sphere.Comment: 34 pages, 1 figur
Novel TMC8 splice site mutation in epidermodysplasia verruciformis and review of HPV infections in patients with the disease
Epidermodysplasia verruciformis (EV) is a genodermatosis leading to infections with cutaneous HPV, persistent plane warts and a high rate of non-melanoma skin cancer (NMSC). Biallelic loss-of-function mutations in TMC6 and TMC8 are known to be causative.; The aim of this study was to report EV-causing mutations in four patients with EV and to give an overview of all described patients with EV.; We investigated four patients with classical features of EV from two families. All patients were affected by plane warts with typical EV histology since early childhood, and ÎČ-HPVs were detected on their skin. One patient had recurring cutaneous squamous cell carcinomas (cSCC) and carcinomas in situ (Bowen type). We sequenced both TMC6/8 for disease-causing mutations and quantified levels of gene expression. We also performed a systematic literature review to discuss these patients in the context of previously reported cases, mutations already identified, as well as HPV types.; Three patients of one family carried a homozygous splice site mutation in TMC8 resulting in aberrantly spliced transcripts that were not degraded. By contrast, no TMC6/8 mutation was detected in the patient from the other family. A systematic literature review revealed 501 described patients with EV. Around 40% of patients with EV analysed for genetic alterations carried no mutation in TMC6/8. While ÎČ-HPVs were identified in the majority of cases, α-HPVs were detected in several individuals.; The relatively high proportion of EV patients without mutation in TMC6/8 indicates the existence of EV-causing mutations in additional, presently unknown gene(s). However, a homozygous TMC8 splice site mutation in our patients resulted in aberrant transcripts which cannot retain the healthy phenotype. The literature review revealed that HPV-5 is the most commonly identified HPV in patients with EV, but HPV-3, HPV-14 and HPV-20 were unexpectedly identified more frequently than HPV-8
Functional identification of biological neural networks using reservoir adaptation for point processes
The complexity of biological neural networks does not allow to directly relate their biophysical properties to the dynamics of their electrical activity. We present a reservoir computing approach for functionally identifying a biological neural network, i.e. for building an artificial system that is functionally equivalent to the reference biological network. Employing feed-forward and recurrent networks with fading memory, i.e. reservoirs, we propose a point process based learning algorithm to train the internal parameters of the reservoir and the connectivity between the reservoir and the memoryless readout neurons. Specifically, the model is an Echo State Network (ESN) with leaky integrator neurons, whose individual leakage time constants are also adapted. The proposed ESN algorithm learns a predictive model of stimulus-response relations in in vitro and simulated networks, i.e. it models their response dynamics. Receiver Operating Characteristic (ROC) curve analysis indicates that these ESNs can imitate the response signal of a reference biological network. Reservoir adaptation improved the performance of an ESN over readout-only training methods in many cases. This also held for adaptive feed-forward reservoirs, which had no recurrent dynamics. We demonstrate the predictive power of these ESNs on various tasks with cultured and simulated biological neural networks
DMLR: Data-centric Machine Learning Research -- Past, Present and Future
Drawing from discussions at the inaugural DMLR workshop at ICML 2023 and
meetings prior, in this report we outline the relevance of community engagement
and infrastructure development for the creation of next-generation public
datasets that will advance machine learning science. We chart a path forward as
a collective effort to sustain the creation and maintenance of these datasets
and methods towards positive scientific, societal and business impact.Comment: This editorial report accompanies the inaugural Data-centric Machine
Learning Research (DMLR) Workshop that took place at ICML 2023
https://dmlr.ai
Secondary crystalline phases identification in Cu2ZnSnSe4 thin films: contributions from Raman scattering and photoluminescence
In this work, we present the Raman peak
positions of the quaternary pure selenide compound
Cu2ZnSnSe4 (CZTSe) and related secondary phases that
were grown and studied under the same conditions. A vast
discussion about the position of the X-ray diffraction
(XRD) reflections of these compounds is presented. It is
known that by using XRD only, CZTSe can be identified
but nothing can be said about the presence of some secondary
phases. Thin films of CZTSe, Cu2SnSe3, ZnSe,
SnSe, SnSe2, MoSe2 and a-Se were grown, which allowed
their investigation by Raman spectroscopy (RS). Here we
present all the Raman spectra of these phases and discuss
the similarities with the spectra of CZTSe. The effective
analysis depth for the common back-scattering geometry
commonly used in RS measurements, as well as the laser penetration depth for photoluminescence (PL) were estimated
for different wavelength values. The observed
asymmetric PL band on a CZTSe film is compatible with
the presence of CZTSe single-phase and is discussed in the
scope of the fluctuating potentialsâ model. The estimated
bandgap energy is close to the values obtained from
absorption measurements. In general, the phase identification
of CZTSe benefits from the contributions of RS and
PL along with the XRD discussion.info:eu-repo/semantics/publishedVersio
- âŠ