Results from the Solar Hidden Photon Search (SHIPS)

We present the results of a search for transversely polarised hidden photons (HPs) with $\sim 3$ eV energies emitted from the Sun. These hypothetical particles, known also as paraphotons or dark sector photons, are theoretically well motivated for example by string theory inspired extensions of the Standard Model. Solar HPs of sub-eV mass can convert into photons of the same energy (photon$\leftrightarrow$HP oscillations are similar to neutrino flavour oscillations). At SHIPS this would take place inside a long light-tight high-vacuum tube, which tracks the Sun. The generated photons would then be focused into a low-noise photomultiplier at the far end of the tube. Our analysis of 330 h of data (and {330 h} of background characterisation) reveals no signal of photons from solar hidden photon conversion. We estimate the rate of newly generated photons due to this conversion to be smaller than 25 mHz/m$^2$ at the 95$$ C.L. Using this and a recent model of solar HP emission, we set stringent constraints on $\chi$, the coupling constant between HPs and photons, as a function of the HP mass

The CRIRES Search for Planets Around the Lowest-Mass Stars. I. High-Precision Near-Infrared Radial Velocities with an Ammonia Gas Cell

Radial velocities measured from near-infrared spectra are a potentially powerful tool to search for planets around cool stars and sub-stellar objects. However, no technique currently exists that yields near-infrared radial velocity precision comparable to that routinely obtained in the visible. We describe a method for measuring high-precision relative radial velocities of these stars from K-band spectra. The method makes use of a glass cell filled with ammonia gas to calibrate the spectrograph response similar to the "iodine cell" technique that has been used very successfully in the visible. Stellar spectra are obtained through the ammonia cell and modeled as the product of a Doppler-shifted template spectrum of the object and a spectrum of the cell, convolved with a variable instrumental profile model. A complicating factor is that a significant number of telluric absorption lines are present in the spectral regions containing useful stellar and ammonia lines. The telluric lines are modeled simultaneously as well using spectrum synthesis with a time-resolved model of the atmosphere over the observatory. The free parameters in the complete model are the wavelength scale of the spectrum, the instrumental profile, adjustments to the water and methane abundances in the atmospheric model, telluric spectrum Doppler shift, and stellar Doppler shift. Tests of the method based on the analysis of hundreds of spectra obtained for late M dwarfs over six months demonstrate that precisions of ~5 m/s are obtainable over long timescales, and precisions of better than 3 m/s can be obtained over timescales up to a week. The obtained precision is comparable to the predicted photon-limited errors, but primarily limited over long timescales by the imperfect modeling of the telluric lines.Comment: Accepted for publication in Ap

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population