Is PSA Still the Best Predictor for Biochemical Recurrence after Radical Prostatectomy in High-Risk Prostate Cancer?

Background Patients with high-risk prostate cancer (PCa) experience heterogeneous oncological outcomes. In this study, we assessed the patients who underwent an RP procedure because of high-risk prostate cancer in subgroups formed according to D’Amico criteria and analyzed the effects of these criteria on biochemical recurrence (BCR) after RP. Methods We retrospectively identified high-risk non-metastatic PCa patients who underwent RP between 2006 and 2020 in our hospital. Groups were formed as follows: group 1 consisted of those with an ISUP grade 4 − 5 biopsy, group 2 consisted of those with a clinical stage T2c, group 3 consisted of those with a tPSA level ≥ 20 ng/ml, and group 4 consisted of those with locally advanced disease. Survival analyses were made by Kaplan–Meier test and Log Rank test. A P value  0.05). Conclusion Despite the developments in the imaging technology, an elevated tPSA level remains to be an important predictor for BCR-free survival

The relationships between metabolic syndrome, erectile dysfunction and lower urinary tract symptoms associated with benign prostatic hyperplasia

WOS: 000360378600002PubMed ID: 26328190Amaç: Benign prostat hiperplazisi (BPH) nedeni ile alt üriner sistem semptomları (AÜSS) olan hastalarda, erektil disfonksiyon (ED) ve metabolik sendrom (MetS) arasındaki ilişkinin belirlenmesi amaçlanmıştır. Gereç ve yöntemler: Polikliniğimize BPH’ya bağlı AÜSS nedeniyle başvuran 40 yaş üstü 78 hasta çalışmaya kabul edildi. Hastalara AÜSS ve ED değerlendirilmesi için sırası ile uluslararası prostat semptom skoru (IPSS), Uluslararası erektil fonksiyon indeksi (IIEF-5) formları dolduruldu. MetS tanısı için the National Cholesterol Education Program Adult Treatment Panel III kriteri kullanıldı. AÜSS, IPSS’a göre hafif, orta ve şiddetli olarak, ED ise IIEF-5 skoruna göre ise hafif, orta-hafif, orta, şiddetli gruplarına ayrılarak incelendi. Bu üç durumun birbirleri ile ve yaşa göre ilişkilerin değerlendirilmesinde Student’s t test, Mann-Whitney U, ANOVA, ki-kare, Fisher Exact testi ve Pearson korelasyon analizi kullanıldı. P0.05). There was a positive correlation with age and severity of LUTS but this relationship was not found to be statistically significant (p>0.05). Mean age of the patients with ED was significantly higher than those without (p<0.001). A statistically significant relationship was not observed between the mean IPSS scores and the severity of LUTS with Mets. However, we observed a weakly positive correlation between triglyceride levels and IPSS. Mean IIEF-5 scores of the patients with MetS were significantly lower than those of the patients without MetS. Severity of ED in the patients with MetS was significantly higher than patients without MetS. The percentage of ED in patients with severe LUTS was found to be statistically higher than other patients with mild, and moderate LUTS. In addition, we found a low degree of negative correlation between IPSS and IIEF-5 scores. Conclusion: In patients with LUTS as a consequence of BPH, when severity of symptoms increases, frequency of MetS increases proportionally and severe ED is observed much more frequently