4 research outputs found
Both Lewis and Secretor Status Mediate Susceptibility to Rotavirus Infections in a Rotavirus GenotypeâDependent Manner
Background. The live oral rotavirus (RV) vaccines have shown a reduced efficacy in Africa. Recent in vitro studies have shown binding of the RV surface protein (VP4) to histoâblood group antigens (HBGAs) in an RV genotypeâdependent manner, suggesting them to be putative receptors for RV. The diversity of HBGA phenotypes in different ethnic populations, combined with prevalence/absence of specific RV genotypes, led us to hypothesize whether the genetic variations in HBGAs in a population limit susceptibility to certain RV genotypes, plausibly leading to reduced vaccine efficacy