5 research outputs found
BIOADHESIVE AND MECHANICAL PROPERTIES OF TRIAMCINOLONE ACETONIDE BUCCAL GELS
Bioadhesive drug delivery systems are the most widely used approach which aims to provide high drug concentrations in the oral cavity for a long period of time. A formulation which has been designed for buccal application must exhibit acceptable mechanical characteristics. Texture profile analysis is a method which determines the mechanical properties of polymeric systems. The aim of this study was to develop different buccal gel formulations with several bioadhesive polymers for oral mucosal ulcerations as an alternative to commercial product and to compare the effect of bioadhesive polymers on the mechanical and textural properties of the gel formulations. For these purposes, the gel formulations containing Triamcinolone acetonide were prepared by using Polaxamer 407, Carbopol 934, chitosan and HPMC. All the developed formulations were compared with commercial product which is containing 0.1% triamcinolone acetonide (Kenacort-A Orabese®). According to the results, it was observed that the bioadhesive properties of the formulations depends on the bioadhesive polymer concentration and molecular weight of chitosan. It was also noted that, the bioadhesive performance of the chitosan based formulations was improved with HPMC. Texture profile analysis (TPA) results indicated that mechanical properties of the developed gels are more suitable than the commercial produc
Bacterial Membrane Vesicles as Smart Drug Delivery and Carrier Systems: A New Nanosystems Tool for Current Anticancer and Antimicrobial Therapy
Bacterial membrane vesicles (BMVs) are known to be critical communication tools in several pathophysiological processes between bacteria and host cells. Given this situation, BMVs for transporting and delivering exogenous therapeutic cargoes have been inspiring as promising platforms for developing smart drug delivery systems (SDDSs). In the first section of this review paper, starting with an introduction to pharmaceutical technology and nanotechnology, we delve into the design and classification of SDDSs. We discuss the characteristics of BMVs including their size, shape, charge, effective production and purification techniques, and the different methods used for cargo loading and drug encapsulation. We also shed light on the drug release mechanism, the design of BMVs as smart carriers, and recent remarkable findings on the potential of BMVs for anticancer and antimicrobial therapy. Furthermore, this review covers the safety of BMVs and the challenges that need to be overcome for clinical use. Finally, we discuss the recent advancements and prospects for BMVs as SDDSs and highlight their potential in revolutionizing the fields of nanomedicine and drug delivery. In conclusion, this review paper aims to provide a comprehensive overview of the state-of-the-art field of BMVs as SDDSs, encompassing their design, composition, fabrication, purification, and characterization, as well as the various strategies used for targeted delivery. Considering this information, the aim of this review is to provide researchers in the field with a comprehensive understanding of the current state of BMVs as SDDSs, enabling them to identify critical gaps and formulate new hypotheses to accelerate the progress of the field