Flexible Birnbaum-Saunders distribution

In this paper, we propose a bimodal extension of the Birnbaum–Saunders model by including an extra parameter. This new model is termed flexible Birnbaum–Saunders (FBS) and includes the ordinary Birnbaum–Saunders (BS) and the skew Birnbaum–Saunders (SBS) model as special cases. Its properties are studied. Parameter estimation is considered via an iterative maximum likelihood approach. Two real applications, of interest in environmental sciences, are included, which reveal that our proposal can perform better than other competing models.Ministerio de Economía y Competitividad (MINECO). Españ

Generalized modified slash Birnbaum–Saunders distribution

In this paper, a generalization of the modified slash Birnbaum-Saunders (BS) distribution is introduced. The model is defined by using the stochastic representation of the BS distribution, where the standard normal distribution is replaced by a symmetric distribution proposed by Reyes et al. It is proved that this new distribution is able to model more kurtosis than other extensions of BS previously proposed in the literature. Closed expressions are given for the pdf (probability density functio), along with their moments, skewness and kurtosis coefficients. Inference carried out is based on modified moments method and maximum likelihood (ML). To obtain ML estimates, two approaches are considered: Newton-Raphson and EM-algorithm. Applications reveal that it has potential for doing well in real problems

SELNET clinical practice guidelines for bone sarcoma

Bone sarcoma are infrequent diseases, representing < 0.2% of all adult neoplasms. A multidisciplinary management within reference centers for sarcoma, with discussion of the diagnostic and therapeutic strategies within an expert multidisciplinary tumour board, is essential for these patients, given its heterogeneity and low frequency. This approach leads to an improvement in patient's outcome, as demonstrated in several studies. The Sarcoma European Latin-American Network (SELNET), aims to improve clinical outcome in sarcoma care, with a special focus in Latin-American countries. These Clinical Practice Guidelines (CPG) have been developed and agreed by a multidisciplinary expert group (including medical and radiation oncologist, surgical oncologist, orthopaedic surgeons, radiologist, pathologist, molecular biologist and representatives of patients advocacy groups) of the SELNET consortium, and are conceived to provide the standard approach to diagnosis, treatment and follow-up of bone sarcoma patients in the Latin-American context