Relationship between CO_MFcorr. and CO_TD.

<p>COMFcorr. determined in 26 patients (48 values). <b>(A)</b> For each subject, CO_MFcorr. values were plotted against the corresponding CO_TD values. The broken line corresponds to the line of equality, solid line is the mean regression lines and dotted lines delimit the confidence interval of the regression lines. <b>(B)</b> Difference between CO_MFcorr. and CO_TD values plotted against their mean. Broken line represents the mean (-0.03 L·min^-1) and the solid lines the 95% limits of agreement (-1.23 L·min^-1 to +1.17 L·min^-1).</p

Study profile.

<p>PH: Pulmonary hypertension; LHD–PH: PH due to left heart disease; ILD–PH: PH due to interstitial lung disease; PAH: Pulmonary arterial hypertension; CTEPH: Chronic thromboembolic PH.</p

Relationship between CO_MFcorr. and CO_TD during exercise.

<p>CO_MFcorr determined in 6 patients during exercise procedure. <b>(A)</b> For each subject, CO_MFcorr values were plotted against the corresponding CO_TD values. The broken line corresponds to the line of equality, solid line is the mean regression lines and dotted lines delimit the confidence interval of the regression lines. <b>(B)</b> Difference between CO_MFcorr and CO_TD values plotted against their mean. Broken line represents the mean (-0.15 L·min^-1) and the solid lines the 95% limits of agreement (-1.42 l.min^-1 to +1.12 L·min^-1). <b>(C)</b> For each subject and workload, the increase (Δ) in CO_MFcorr from rest was plotted against the same corresponding CO_TD increase (ΔCO_TD). The six different targets correspond to the six different patients. The broken line corresponds to the line of equality.</p

Diagnosis and treatment of the CTEPH population (%).

<p>ERA: Endothelin receptors antagonists; PDE5i: phosphodiesterase-5 inhibitors; CCB: Calcium channel blockers. #Patients with PAH associated to connective tissue disease (n = 1), HIV infection (n = 2), Portal hypertension (n = 2) and Congenital heart disease after corrective cardiac surgery (n = 4).</p><p>§Patients diagnosed at the time of the present study.</p><p>**Due to distal lesions.</p><p>¶ Patients with persisting hemodynamic impairment at least 3 months after pulmonary endarterectomy (PEA).</p><p>Diagnosis and treatment of the CTEPH population (%).</p

Baseline characteristics of the study population.

<p>Data are presented as mean ± SD unless otherwise stated. BMI: Body mass index; BSA: Body surface area; MAP: Mean systemic arterial blood pressure; RAP: Right atrial pressure; mPAP: Pulmonary artery mean pressure; PAWP: pulmonary artery wedge pressure; CO: cardiac output, determined by thermodilution; CI: Cardiac Index; PVR: Pulmonary vascular resistance; SVR: Systemic vascular resistance; WU: Wood units.</p><p>Baseline characteristics of the study population.</p

Relationship between CO_MF and CO_TD.

<p>COMF determined in 50 patients (98 values) under various conditions (rest, fluid challenge, NO testing and exercise). CO_MF values were plotted against the corresponding CO_TD values for CTEPH patients <b>(A)</b> PAH patients <b>(B)</b> and all 50 patients <b>(C)</b>. <b>(D)</b> Difference between CO_MF and CO_TD values plotted against their mean. In (A), (B) and (C), the broken lines correspond to the lines of equality, solid lines are the mean regression lines and dotted lines delimit the confidence interval of the regression lines. In (D), broken line represents the mean (+ 1.05 L·min^-1) and the solid lines the 95% limits of agreement (-1.30 to + 3.40 l.min^-1).</p

Diagnosis and treatment of the PAH population (%).

<p>Diagnosis and treatment of the PAH population (%).</p

Conditions and number of simultaneous CO_TD and CO_MF measurements.

<p>Repartition of the different single simultaneous CO_TD and CO_MF measurements. A total of 98 CO measurements were performed in the 50 patients. Each CO_TD is the mean of 3 TD measurements (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0134221#sec006" target="_blank">Methods</a>). Each CO_MF is the mean of 100 consecutive beat-by-beat values (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0134221#sec006" target="_blank">Methods</a>). 26 patients (PAH n = 12, CTEPH n = 14) had a total of 48 measurements in conditions other than basal (PAH n = 25, CTEPH n = 23). #6 patients performed incremental exercise (PAH n = 4, CTEPH n = 2) with the workload being increased stepwise by 20 W every 3 min to a maximal workload of 60 W depending of patient functional tolerance for a total of 16 CO determined during steady exercise (PAH n = 9, CTEPH n = 7). NO: Nitric oxide vasoreactivity test; Fluid Challenge: CO determined after infusion of 500 ml of isotonic saline solution in five minutes; Bicycle rest: CO determined after 5 min of rest with feet positioned on the pedals with raised legs.</p><p>Conditions and number of simultaneous CO_TD and CO_MF measurements.</p

Comparison of baseline values of CO_MF and CO_TD.

<p>Simultaneous determination of cardiac output by thermodilution (CO_TD) and Modelflow (CO_MF) in 50 patients with pre-capillary pulmonary hypertension. <b>(A)</b> The figure describes median (line), 25th to 75th percentile (box), 5th to 95th percentile (whiskers) and the dots represent outliers. The mean values for CO_TD and CO_MF were 5.46 ± 1.95 L·min^-1 and 6.18 ± 1.95 L·min^-1, respectively (p<0.05). <b>(B)</b> Difference between resting CO_MF and CO_TD values plotted against their mean. Broken line represents the mean (+ 0.72 L·min^-1) and the solid lines the 95% limits of agreement (-1.32 to + 2.76 L·min^-1).</p

Predictive factors of hemodynamic normalization^*.

<p>Predictive factors of hemodynamic normalization^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0198198#t004fn002" target="_blank">*</a>}.</p