Innovative concept of compliant mechanisms made by additive manufacturing

The complete redesign for Additive Manufacturing of compliant mechanism structures enables CSEM to develop innovative concepts to drastically reduce the need of machining and assembly after additive manufacturing. Support structures under flexure blades are thus minimised and the overall process becomes more streamlined. Moreover, this concept allows us to easily design and produce monolithic cross flexure pivots with interlocked flexible blades. Based on this concept, CSEM is now developing new architectures of Compliant Mechanisms based on Additive Manufacturing (COMAM) for the European Space Agency (ESA) in the frame of a GSTP research project. The past and current work of design, 3D printing and testing on several compliant mechanisms are presented. These demonstrators will be used as use-case for future high-precision and harsh environment applications such as cryogenic and space

The transcription factor Zic4 promotes tentacle formation and prevents epithelial transdifferentiation in Hydra

The molecular mechanisms that maintain cellular identities and prevent dedifferentiation or transdifferentiation remain mysterious. However, both processes are transiently used during animal regeneration. Therefore, organisms that regenerate their organs, appendages, or even their whole body offer a fruitful paradigm to investigate the regulation of cell fate stability. Here, we used Hydra as a model system and show that Zic4, whose expression is controlled by Wnt3/β-catenin signaling and the Sp5 transcription factor, plays a key role in tentacle formation and tentacle maintenance. Reducing Zic4 expression suffices to induce transdifferentiation of tentacle epithelial cells into foot epithelial cells. This switch requires the reentry of tentacle battery cells into the cell cycle without cell division and is accompanied by degeneration of nematocytes embedded in these cells. These results indicate that maintenance of cell fate by a Wnt-controlled mechanism is a key process both during homeostasis and during regeneration. </p