Henri Temianka Correspondence; (spivakovsky)

https://digitalcommons.chapman.edu/temianka_correspondence/2868/thumbnail.jp

Correlation between androgen levels and dry eye parameters in males with chronic obstructive pulmonary disease

Objective: To investigate the effects of chronic obstructive pulmonary disease (COPD) in dry eye status in males and whether the hypoandrogenic status has any concomitant impact.Methods: Eighty patients with stable COPD and individually matched healthy volunteers on the basis of body mass index (BMI), age, and sex were enrolled. Ocular surface testing included ocular surface disease index (OSDI) questionnaire, evaluation of meibomian gland dysfunction (MGD), tear fluorescein break-up time (TF-BUT), ocular surface staining with lissamine green (LG), Schirmer test with topical anesthesia and Sirius meibographic analysis of meibomian gland area (MGA) loss. Bioavailable testosterone and free testosterone (fT) were measured through the measured total testosterone (TT), albumin, and sex hormone binding globulin (SHBG) concentrations.Results: Patients with COPD had lower levels of circulating androgens, decreased TF-BUT and Schirmer score and increased LG staining score, MGD grade and MG area loss compared to healthy controls (p&lt;0.01). Forced expiratory volume in 1-second (FEV1), FEV1/forced expiratory vital capacity (FVC) and circulating androgen levels were inversely correlated to OSDI score, LG staining, MGD grade and MGA loss and showed positive correlation with TF-BUT and Schirmer score in patients with COPD (p&lt;0.01). However, when adjusted for androgen levels, FEV1 and FEV1/FVC ratio showed a negative correlation with Schirmer score (p&lt;0.05).Conclusion: Males with COPD had worse tear film parameters, and this finding was more notable in patients with lower androgen levels. Hypoandrogenic status in patients with COPD attributes to dry eye status of the patients independent of their FEV1 and FEV1/FVC status.</p

Correlation Between Androgen Levels and Dry Eye Parameters in Male Patients with Chronic Obstructive Pulmonary Disease

Objective: To investigate the effects of chronic obstructive pulmonary disease (COPD) in the dry eye status in men and to determine whether the hypoandrogenic status has any concomitant impact

Epidermoid carcinoma of the lung with isolated penile metastasis.

We report a case of epidermoid-cell carcinoma of the lung that developed a metastatic lesion in the penis. A 50-year-old male patient was admitted to our hospital with bloody sputum and cough. He had a left pneumectomy and was diagnosed with epidermoid carcinoma of the lung at stage IIB (T2N1M0). He was started on an adjuvant chemotherapy protocol consisting of cisplatin and paclitaxel. He was admitted to our urology clinic with obstructive symptoms during urination and pain during penile erection. Physical examination revealed a firm, 3 cm x 2 cm palpable mass on the radix of his penis. A fine-needle aspiration biopsy of the penile mass revealed epidermoid carcinoma that was consistent with lung cancer. The patient was considered to have penile metastasis from epidermoid carcinoma of the lung

Miliary Tuberculosis Due to BCG Immunotherapy

High fever, dyspnea and cough occurred in a patient with bladder carcinom under treatment of intravesical Bacillus Calmette-Guérin (BCG) therapy. Chest roentgenogram revealed bilateral reticulonodular infiltrates. Sputum and broncoalveolar fluid smears showed acid-fast bacilli and Mycobacteria was isolated from cultures