Investigation of photophysical behaviours and antimicrobial activity of novel benzo-15-crown-5 substituted coumarin and chromone derivatives

Two different series of crown ether compounds (4-11) were synthesized by the reactions of 4',5'-bis(bromomethyl)benzo-15-crown-5 (3) and 4'-amino-benzo-15-crown-5 with hydroxycoumarin and chromone derivatives. Coumarin-crown ether compounds (4 and 5) were synthesized by the reactions of 4',5'-bis(bromomethyl)benzo-15-crown-5 (3) with 4-hydroxycoumarin and 7-hydroxycoumarin. Chromone-crown ether compounds (6-11), were synthesized by the condensation reactions of 4'-aminobenzo-15-crown-5 with 3-formylchromone and 6-methyl-3-formylchromone in different solvent media. Sodium and potassium complexes (4a-11a, 4b-11b) of new coumarin and chromone substituted benzo-15-crown-5 (B15C5) ligands (4-11) were prepared with NaSCN and KSCN, respectively. The syntheses of the novel crown ether compounds (4-11) and complexes (4a-11a, 4b-11b) were elucidated by the elemental analysis, FTIR, H-1 NMR, C-13 NMR and MS spectral data. The metal selectivities and effects of metal cations (Li+, Na+, K+, Mg2+, Ca2+, Ba2+, Ag+, Al3+, Cu2+, Zn2+, Ni2+, Pb2+, Fe3+, Cr3+) to the new crown ether compounds (4-11) were investigated by the absorption and fluorescence spectra. In addition, all of these substances were examined for antibacterial activity against pathogenic strains Listeria monocytogenes 4b, Staphylococcus aureus, Escherichia coli, Salmonella typhi H, Bacillus cereus, Micrococcus luteus, Shigella dysenteria type 2, Staphylococcus epidermidis, Proteus vulgaris, Klebsiella pneumonia sp., Serratia marcescens sp. and antifungal activity against Candida albicans. (C) 2019 Elsevier B.V. All rights reserved

Electroconvulsive Therapy in Child and Adolescent Psychiatry

Electroconvulsive therapy (ECT) is one of the effective treatment methods which was used in treatment of childhood and adolescent psychiatry. Although the effects and side effects of ECT intervention in child and adolescent psychiatry is similar adult psychiatry, mental health professionals might be reluctant to prefer ECT in children and adolescents due to limited knowledge and negative attitude to ECT. Because the articles on ECT among child and adolescent with severe mental disorders were limited studies of case reports, it could not reach any article which evaluated ECT holistically, it was thought to discuss ECT intervention, legal issue and nursing care in this issue and this review will contribute to the literature about ECT in children and adolescents

Evaluation of Anesthesia-related Knowledge and Concerns of Patients According to Their Education Levels: A Survey Study

Introduction:The adequate level of anesthesia practices in the community and the role of aids in the hospital could not be reached. In this study, the purpose was to evaluate the relationship between the education level of patients receiving anesthesia, their knowledge, and fears about anesthesia.Methods:The educational status of the patients was evaluated by questioning their age, educational status, and concerns about anesthesia.Results:It was concluded that the level of knowledge about anesthesia increased as the level of education of patients increased, but the fears of patients related to anesthesia were similar.Conclusion:As the education level of the patients increases, their level of knowledge about anesthesia increases. We think that communication with anesthesiologists in the preoperative period will reduce patients’ fears about anesthesia

Coexistence of postpartum cardiomyopathy and single coronary artery anomaly

Postpartum cardiomyopathy (PPCM) is dilated cardiomyopathy seen in the postpartum period in women who no prior history of cardiac diseases. In this case study, coronary angiography was used to determine the etiology of the cardiomyopathy after the decompensated heart failure had regressed. A congenital single coronary artery anomaly was detected by coronary angiography. In this case, PPCM can mimic pneumonia, thus making diagnosis difficult. When there is no response to antibiotic therapy, the obstetrician must consider cardiac disease and appropriate consultation should be obtained as soon as possible. To the best of our knowledge, single coronary artery anomalies coexisting with PPCM has only been documented in one other case in the literature. An association of single coronary artery anomalies with PPCM may be random, or, alternative, might contribute to the composition of the PPCM

Coexistence of postpartum cardiomyopathy and single coronary artery anomaly

Postpartum cardiomyopathy (PPCM) is dilated cardiomyopathy seen in the postpartum period in women who no prior history of cardiac diseases. In this case study, coronary angiography was used to determine the etiology of the cardiomyopathy after the decompensated heart failure had regressed. A congenital single coronary artery anomaly was detected by coronary angiography. In this case, PPCM can mimic pneumonia, thus making diagnosis difficult. When there is no response to antibiotic therapy, the obstetrician must consider cardiac disease and appropriate consultation should be obtained as soon as possible. To the best of our knowledge, single coronary artery anomalies coexisting with PPCM has only been documented in one other case in the literature. An association of single coronary artery anomalies with PPCM may be random, or, alternative, might contribute to the composition of the PPCM

Coexistence of postpartum cardiomyopathy and single coronary artery anomaly

Postpartum cardiomyopathy (PPCM) is dilated cardiomyopathy seen in the postpartum period in women who no prior history of cardiac diseases. In this case study, coronary angiography was used to determine the etiology of the cardiomyopathy after the decompensated heart failure had regressed. A congenital single coronary artery anomaly was detected by coronary angiography. In this case, PPCM can mimic pneumonia, thus making diagnosis difficult. When there is no response to antibiotic therapy, the obstetrician must consider cardiac disease and appropriate consultation should be obtained as soon as possible. To the best of our knowledge, single coronary artery anomalies coexisting with PPCM has only been documented in one other case in the literature. An association of single coronary artery anomalies with PPCM may be random, or, alternative, might contribute to the composition of the PPCM

Coexistence of postpartum cardiomyopathy and single coronary artery anomaly

Postpartum cardiomyopathy (PPCM) is dilated cardiomyopathy seen in the postpartum period in women who no prior history of cardiac diseases. In this case study, coronary angiography was used to determine the etiology of the cardiomyopathy after the decompensated heart failure had regressed. A congenital single coronary artery anomaly was detected by coronary angiography. In this case, PPCM can mimic pneumonia, thus making diagnosis difficult. When there is no response to antibiotic therapy, the obstetrician must consider cardiac disease and appropriate consultation should be obtained as soon as possible. To the best of our knowledge, single coronary artery anomalies coexisting with PPCM has only been documented in one other case in the literature. An association of single coronary artery anomalies with PPCM may be random, or, alternative, might contribute to the composition of the PPCM

Effect of the Position on Hemodynamic Parameters in Elective Cesarean Sections with Spinal Anesthesia: A Retrospective Clinical Trial

Aim:Maternal hypotension after spinal anesthesia is the most common complication. We aimed to compare the haemodynamic effects of patient positions (supine or tilt) applied to avoid spontaneous hypotension in elective cesarean sections performed in our clinic with spinal anesthesia by examining the files of anesthesia records retrospectively.Methods:Data on the 133 elective caesarean sections done in 2017 was examined. Hemodynamic parameters, table position, use of ephedrine, need for additional drugs, and nausea and vomiting were recorded. Surgery started in the supine position in 64 patients (group S), and in the tilt position in 69 (group T). Group T was subdivided into 2 groups: group TS consisted of 29 patients in whom surgery started in the tilt, and continued in the supine position and group TT included 40 patients in whom the surgery was completed in the tilt position.Results:The hemodynamic values in group S were significantly lower than in group T, and a total of 43 patients were administered ephedrine. It was found that in group TT, only four of 40 patients required ephedrine and the total dose was lower than in other groups.Conclusion:We concluded that in elective cesarean sections, maternal hypotension in patients undergoing spinal anesthesia with 15°C tilt position on the left side of the patient is seen less than in patients undergoing in the supine position. In addition, starting with a 15°C tilt position and changing position to the supine position, make a deeper hypotension and increase the dose of ephedrine used

Could Local Application of Hypoxia Inducible Factor 1-alpha Enhancer Deferoxamine Be Promising for Preventing of Medication-Related Osteonecrosis of the Jaw?

This experimental study investigates the prophylactic effect of deferoxamine (DFO) on medication-related osteonecrosis of the jaw (MRONJ). Thirty-six female Sprague Dawley rats received zoledronic acid (ZA) for eight weeks to create an osteonecrosis model. DFO was locally applied into the extraction sockets with gelatin sponge (GS) carriers to prevent MRONJ. The specimens were histopathologically and histomorphometrically evaluated. Hypoxia-inducible factor 1-alpha (HIF-1 alpha) protein levels in the extraction sockets were quantified. New bone formation rate differed significantly between groups (p = 0.005). Newly formed bone ratios in the extraction sockets did not differ significantly between the control group and the GS (p = 1), GS/DFO (p = 0.749), ZA (p = 0.105), ZA-GS (p = 0.474), and ZA-GS/DFO (p = 1) groups. While newly formed bone rates were higher in the ZA-GS and ZA-GS/DFO groups than in the ZA group, the differences were not significant. HIF-1 alpha levels differed significantly between groups (p < 0.001) and were significantly higher in the DFO and ZA-GS/DFO groups than in the control group (p = 0.001 and p = 0.004, respectively). While HIF-1 alpha levels were higher in the ZA-GS/DFO group than in the ZA group, the difference was not significant. While HIF-1 alpha protein levels and new bone formation rate were elevated in the DFO-treated group, the effect was not significant. Further large-scale studies are needed to understand DFO's preventative effects on MRONJ and the role of HIF-1 alpha in MRONJ pathogenesis

Assesment of the Approach to the Painless Delivery: A Survey Study

Aim:Being able to relieve pain that occurs during delivery provides physical and emotional involvement of the mother in the birth and could reduce maternal and fetal undesirable effects. We planned this questionnaire study to evaluate the painless delivery approaches of physicians working in the fields of gynecological diseases and obstetrics.Methods:A survey was made consisting of 10 questions about the painless delivery approaches with the gynecologists and obstetricians in Turkey. Ninety-eight physicians’ answers were evaluated.Results:It was observed that the painless birth in the clinics was not widespread, the low painless delivery options offered rate was low and the informing was inadequate in clinics throughout Turkey. In addition, it was concluded that physicians did not have a common idea to the effect on the action of delivery.Conclusion:The role of gynecologists and obstetricians, as well as anesthesiologists, is great in spreading painless delivery practice. We also wanted to emphasize that informing the patient during pregnancy by the gynecologic diseases and obstetricians may reduce the rate of cesarean delivery due to the patient’s request