1 research outputs found
Studies toward the Synthesis of Iriomoteolide-2a: Construction of the C(6)–C(28) Fragment
The synthesis of an appropriately
functionalized advanced C(6–28)
fragment (<b>3</b>) of the marine macrolide iriomoteolide-2a
(<b>1</b>) has been achieved in a highly efficient manner. The
C(6)–C(18) fragment of <b>1</b> is prepared via a radical
cyclization of a vinyl ether intermediate and palladium-promoted hydrostannylation/iodination.
Paterson aldol reaction and Peterson olefination are used to construct
the C(19)–C(28) fragment. The union of the C(6)–C(18)
and C(19)–C(28) fragments is accomplished via a Suzuki–Miyaura
coupling reaction