A forensic approach to understanding habitat use from stable isotope analysis of (avian) claw material

1. The potential of using stable isotope signatures of avian claws in order to infer diet and habitat use was investigated. 2. Highly significant relationships observed between stable carbon and nitrogen isotope ratios (13C, 15N) in the claws and body feathers of resident birds were expected since it was predicted that they were synthesized in the same habitat and approximately the same time of year. 3. Likewise the non-significant relationships observed between 13C and 15N in the claws and tertial feathers of neotropical migrant birds were also predicted since the claws were synthesized in the wintering area and the tertials in the breeding area. 4. The growth rates measured in the claws of five species of palearctic passerines provide evidence that this tissue should integrate dietary and habitat information over a medium temporal scale (probably weeks to months). 5. It is suggested that claws may offer a unique combination of attributes to the isotope ecologist: they are non-invasively sampled; metabolically inert but grow continuously, and are therefore a more flexible tool than feathers. 6. It is also suggested that that the stable isotope signatures in the claws of mammals and reptiles may provide similar information. 6. It is also suggested that that the stable isotope signatures in the claws of mammals and reptiles may provide similar information

A view from above : changing seas, seabirds and food sources

In this review we summarize what is known about mechanisms by which climate change may be affecting the populations of seabirds around the UK. Breeding success and adult survival are the key factors affecting changes in seabird populations, and food intake is implicated as a major determinant of both. The diet of most UK seabird species is almost exclusively sandeels, small clupeoid fish or zooplankton and it is clear that the marine pelagic food web is the key ecological system determining food supply. Hence, we develop the review by first considering how climate changes may affect primary production, and then examine how this propagates through the food web to zooplankton and fish culminating in fluctuations in seabird numbers. A trend of increasing numbers of many seabird species since 1970, particularly puffins, guillemots and razorbills, appears to have been reversed since 2000. The proximate cause of the recent declines seems to be a succession of 5 years of low breeding success for a range of species due to a shortage of food, especially sandeels. However, the connection with climate change remains uncertain, though there are indications that declines in the productivity of sandeel populations may be linked in some complex way to warming sea temperatures. The main conclusion is that no part of the marine food web, including fisheries, can be considered in isolation when trying to understand and predict the consequences of climate change for seabirds. Impacts can be expected in all parts of the system, and all parts of the system are interconnected

Rapid, learning-induced inhibitory synaptogenesis in murine barrel field

The structure of neurons changes during development and in response to injury or alteration in sensory experience. Changes occur in the number, shape, and dimensions of dendritic spines together with their synapses. However, precise data on these changes in response to learning are sparse. Here, we show using quantitative transmission electron microscopy that a simple form of learning involving mystacial vibrissae results in approximately 70% increase in the density of inhibitory synapses on spines of neurons located in layer IV barrels that represent the stimulated vibrissae. The spines contain one asymmetrical (excitatory) and one symmetrical (inhibitory) synapse (double-synapse spines), and their density increases threefold as a result of learning with no apparent change in the density of asymmetrical synapses. This effect seems to be specific for learning because pseudoconditioning (in which the conditioned and unconditioned stimuli are delivered at random) does not lead to the enhancement of symmetrical synapses but instead results in an upregulation of asymmetrical synapses on spines. Symmetrical synapses of cells located in barrels receiving the conditioned stimulus also show a greater concentration of GABA in their presynaptic terminals. These results indicate that the immediate effect of classical conditioning in the "conditioned" barrels is rapid, pronounced, and inhibitory

Australian cardiac rehabilitation exercise parameter characteristics and perceptions of high-intensity interval training: a cross-sectional survey

Purpose: This study explored current demographics, characteristics, costs, evaluation methods, and outcome measures used in Australian cardiac rehabilitation (CR) programs. It also determined the actual usage and perceptions of high-intensity interval training (HIIT). Methods: A cross-sectional observational web-based survey was distributed to 328 Australian CR programs nationally. Results: A total of 261 programs completed the survey (79.6% response rate). Most Australian CR programs were located in a hospital setting (76%), offered exercise sessions once a week (52%) for 6–8 weeks (49%) at moderate intensity (54%) for 46–60 min (62%), and serviced 101–500 clients per annum (38%). HIIT was reported in only 1% of programs, and 27% of respondents believed that it was safe while 42% of respondents were unsure. Lack of staff (25%), monitoring resources (20%), and staff knowledge (18%) were the most commonly reported barriers to the implementation of HIIT. Overall, Australian CR coordinators are unsure of the cost of exercise sessions. Conclusion: There is variability in CR delivery across Australia. Only half of programs reassess outcome measures postintervention, and cost of exercise sessions is unknown. Although HIIT is recommended in international CR guidelines, it is essentially not being used in Australia and clinicians are unsure as to the safety of HIIT. Lack of resources and staff knowledge were perceived as the biggest barriers to HIIT implementation, and there are inconsistent perceptions of prescreening and monitoring requirements. This study highlights the need to educate health professionals about the benefits and safety of HIIT to improve its usage and patient outcomes

High-intensity interval training versus moderate-intensity continuous training within cardiac rehabilitation:a systematic review and meta-analysis

Aerobic capacity has been shown to be inversely proportionate to cardiovascular mortality and morbidity and there is growing evidence that high-intensity interval training (HIIT) appears to be more effective than moderate-intensity continuous training (MICT) in improving cardiorespiratory fitness within the cardiac population. Previously published systematic reviews in cardiovascular disease have neither investigated the effect that the number of weeks of intervention has on cardiorespiratory fitness changes, nor have adverse events been collated.We aimed to undertake a systematic review and meta-analysis of randomized controlled trials (RCTs) within the cardiac population that investigated cardiorespiratory fitness changes resulting from HIIT versus MICT and to collate adverse events.A critical narrative synthesis and meta-analysis was conducted after systematically searching relevant databases up to July 2017. We searched for RCTs that compared cardiorespiratory fitness changes resulting from HIIT versus MICT interventions within the cardiac population.Seventeen studies, involving 953 participants (465 for HIIT and 488 for MICT) were included in the analysis. HIIT was significantly superior to MICT in improving cardiorespiratory fitness overall (SMD 0.34 mL/kg/min; 95% confidence interval [CI; 0.2-0.48]; p6-week duration. Programs of 7-12 weeks' duration resulted in the largest improvements in cardiorespiratory fitness for patients with coronary artery disease. HIIT appears to be as safe as MICT for CR participants

Interventions for the treatment of oral and oropharyngeal cancers: surgical treatment.

BACKGROUND: Surgery is an important part of the management of oral cavity cancer with regard to both the removal of the primary tumour and removal of lymph nodes in the neck. Surgery is less frequently used in oropharyngeal cancer. Surgery alone may be treatment for early stage disease or surgery may be used in combination with radiotherapy, chemotherapy and immunotherapy/biotherapy. There is variation in the recommended timing and extent of surgery in the overall treatment regimens of people with these cancers. OBJECTIVES: To determine which surgical treatment modalities for oral cavity and oropharyngeal cancers result in increased overall survival, disease free survival, progression free survival and reduced recurrence. SEARCH STRATEGY: The following electronic databases were searched: the Cochrane Oral Health Group Trials Register (to 17 February 2011), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 1), MEDLINE via OVID (1950 to 17 February 2011) and EMBASE via OVID (1980 to 17 February 2011). There were no restrictions regarding language or date of publication. SELECTION CRITERIA: Randomised controlled trials where more than 50% of participants had primary tumours of the oral cavity or oropharynx, and which compared two or more surgical treatment modalities or surgery versus other treatment modalities. DATA COLLECTION AND ANALYSIS: Data extraction and assessment of risk of bias was undertaken independently by two or more review authors. Study authors were contacted for additional information as required. Adverse events data were collected from published trials. MAIN RESULTS: Seven trials (n = 669; 667 with cancers of the oral cavity) satisfied the inclusion criteria, but none were assessed as low risk of bias. Trials were grouped into three main comparisons. Four trials compared elective neck dissection (ND) with therapeutic neck dissection in patients with oral cavity cancer and clinically negative neck nodes, but differences in type of surgery and duration of follow-up made meta-analysis inappropriate. Three of these trials reported overall and disease free survival. One trial showed a benefit for elective supraomohyoid neck dissection compared to therapeutic ND in overall and disease free survival. Two trials found no difference between elective radical ND and therapeutic ND for the outcomes of overall survival and disease free survival. All four trials found reduced locoregional recurrence following elective ND.A further two trials compared elective radical ND with elective selective ND and found no difference in overall survival, disease free survival or recurrence. The final trial compared surgery plus radiotherapy to radiotherapy alone but data were unreliable because the trial stopped early and there were multiple protocol violations.None of the trials reported quality of life as an outcome. Two trials, evaluating different comparisons reported adverse effects of treatment. AUTHORS' CONCLUSIONS: Seven included trials evaluated neck dissection surgery in patients with oral cavity cancers. The review found weak evidence that elective neck dissection of clinically negative neck nodes at the time of removal of the primary tumour results in reduced locoregional recurrence, but there is insufficient evidence to conclude that elective neck dissection increases overall survival or disease free survival compared to therapeutic neck dissection. There is very weak evidence from one trial that elective supraomohyoid neck dissection may be associated with increased overall and disease free survival. There is no evidence that radical neck dissection increases overall survival compared to conservative neck dissection surgery. Reporting of adverse events in all trials was poor and it was not possible to compare the quality of life of patients undergoing different surgeries

A downward revision to the distance of the 1806-20 cluster and associated magnetar from Gemini near-Infrared spectroscopy

We present H- and K-band spectroscopy of OB and Wolf-Rayet (WR) members of the Milky Way cluster 1806-20 (G10.0-0.3), to obtain a revised cluster distance of relevance to the 2004 giant flare from the SGR 1806-20 magnetar. From GNIRS spectroscopy obtained with Gemini South, four candidate OB stars are confirmed as late O/early B supergiants, while we support previous mid WN and late WC classifications for two WR stars. Based upon an absolute Ks-band magnitude calibration for B supergiants and WR stars, and near-IR photometry from NIRI at Gemini North plus archival VLT/ISAAC datasets, we obtain a cluster distance modulus of 14.7+/-0.35 mag. The known stellar content of the 1806-20 cluster suggests an age of 3-5 Myr, from which theoretical isochrone fits infer a distance modulus of 14.7+/-0.7 mag. Together, our results favour a distance modulus of 14.7+/-0.4 mag (8.7^+1.8_-1.5 kpc) to the 1806-20 cluster, which is significantly lower than the nominal 15 kpc distance to the magnetar. For our preferred distance, the peak luminosity of the December 2004 giant flare is reduced by a factor of three to 7 X 10^46 erg/s, such that the contamination of BATSE short gamma ray bursts (GRB's) from giant flares of extragalactic magnetars is reduced to a few percent. We infer a magnetar progenitor mass of ~48^+20_-8 Msun, in close agreement with that obtained recently for the magnetar in Westerlund 1.Comment: 6 pages, 4 figures, accepted for MNRAS Letter