7,372 research outputs found
Acute pancreatitis after liver transplantation: incidence and contributing factors
In order to assess the incidence and possible predisposing and contributing factors in the development of acute pancreatitis after liver transplantation, we reviewed the medical records of all 1832 adult patients who underwent 2161 orthotopic liver transplantation (OLTx) procedures in our center between January 1987 and September 1992. Of these patients, 55 (3 % incidence) developed clinical pancreatitis and 247 (13.4 % incidence) developed hyperamylasemia (biochemical pancreatitis). Overall mortality in cases of clinical pancreatitis was 63.6 %. The mortality in cases of hyperamylasemia was similar to that found in the general liver transplant population (i. e., 23 %). A strong correlation was found between pancreatitis after liver transplantation and end-stage liver disease due to hepatitis B (30 % of the cases, P = 0.00001). Extensive surgical dissection around the pancreas (P < 0.05), the type of biliary reconstruction following liver transplantation (P < 0.05), and the number of liver grafts received by the same patient (P = 0.00001) appeared to be possible contributing factors as did the duration of venovenous bypass and the quantity of IV calcium chloride administered intraoperatively
Quantum key distribution with delayed privacy amplification and its application to security proof of a two-way deterministic protocol
Privacy amplification (PA) is an essential post-processing step in quantum
key distribution (QKD) for removing any information an eavesdropper may have on
the final secret key. In this paper, we consider delaying PA of the final key
after its use in one-time pad encryption and prove its security. We prove that
the security and the key generation rate are not affected by delaying PA.
Delaying PA has two applications: it serves as a tool for significantly
simplifying the security proof of QKD with a two-way quantum channel, and also
it is useful in QKD networks with trusted relays. To illustrate the power of
the delayed PA idea, we use it to prove the security of a qubit-based two-way
deterministic QKD protocol which uses four states and four encoding operations.Comment: 11 pages, 3 figure
A Moving Bump in a Continuous Manifold: A Comprehensive Study of the Tracking Dynamics of Continuous Attractor Neural Networks
Understanding how the dynamics of a neural network is shaped by the network
structure, and consequently how the network structure facilitates the functions
implemented by the neural system, is at the core of using mathematical models
to elucidate brain functions. This study investigates the tracking dynamics of
continuous attractor neural networks (CANNs). Due to the translational
invariance of neuronal recurrent interactions, CANNs can hold a continuous
family of stationary states. They form a continuous manifold in which the
neural system is neutrally stable. We systematically explore how this property
facilitates the tracking performance of a CANN, which is believed to have clear
correspondence with brain functions. By using the wave functions of the quantum
harmonic oscillator as the basis, we demonstrate how the dynamics of a CANN is
decomposed into different motion modes, corresponding to distortions in the
amplitude, position, width or skewness of the network state. We then develop a
perturbative approach that utilizes the dominating movement of the network's
stationary states in the state space. This method allows us to approximate the
network dynamics up to an arbitrary accuracy depending on the order of
perturbation used. We quantify the distortions of a Gaussian bump during
tracking, and study their effects on the tracking performance. Results are
obtained on the maximum speed for a moving stimulus to be trackable and the
reaction time for the network to catch up with an abrupt change in the
stimulus.Comment: 43 pages, 10 figure
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Design and Benchmark Testing for Open Architecture Reconfigurable Mobile Spirometer and Exhaled Breath Monitor with GPS and Data Telemetry.
Portable and wearable medical instruments are poised to play an increasingly important role in health monitoring. Mobile spirometers are available commercially, and are used to monitor patients with advanced lung disease. However, these commercial monitors have a fixed product architecture determined by the manufacturer, and researchers cannot easily experiment with new configurations or add additional novel sensors over time. Spirometry combined with exhaled breath metabolite monitoring has the potential to transform healthcare and improve clinical management strategies. This research provides an updated design and benchmark testing for a flexible, portable, open access architecture to measure lung function, using common Arduino/Android microcontroller technologies. To demonstrate the feasibility and the proof-of-concept of this easily-adaptable platform technology, we had 43 subjects (healthy, and those with lung diseases) perform three spirometry maneuvers using our reconfigurable device and an office-based commercial spirometer. We found that our system compared favorably with the traditional spirometer, with high accuracy and agreement for forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC), and gas measurements were feasible. This provides an adaptable/reconfigurable open access "personalized medicine" platform for researchers and patients, and new chemical sensors and other modular instrumentation can extend the flexibility of the device in the future
Dynamics of Neural Networks with Continuous Attractors
We investigate the dynamics of continuous attractor neural networks (CANNs).
Due to the translational invariance of their neuronal interactions, CANNs can
hold a continuous family of stationary states. We systematically explore how
their neutral stability facilitates the tracking performance of a CANN, which
is believed to have wide applications in brain functions. We develop a
perturbative approach that utilizes the dominant movement of the network
stationary states in the state space. We quantify the distortions of the bump
shape during tracking, and study their effects on the tracking performance.
Results are obtained on the maximum speed for a moving stimulus to be
trackable, and the reaction time to catch up an abrupt change in stimulus.Comment: 6 pages, 7 figures with 4 caption
Security proof of a three-state quantum key distribution protocol without rotational symmetry
Standard security proofs of quantum key distribution (QKD) protocols often
rely on symmetry arguments. In this paper, we prove the security of a
three-state protocol that does not possess rotational symmetry. The three-state
QKD protocol we consider involves three qubit states, where the first two
states, |0_z> and |1_z>, can contribute to key generation and the third state,
|+>=(|0_z>+|1_z>)/\sqrt{2}, is for channel estimation. This protocol has been
proposed and implemented experimentally in some frequency-based QKD systems
where the three states can be prepared easily. Thus, by founding on the
security of this three-state protocol, we prove that these QKD schemes are, in
fact, unconditionally secure against any attacks allowed by quantum mechanics.
The main task in our proof is to upper bound the phase error rate of the qubits
given the bit error rates observed. Unconditional security can then be proved
not only for the ideal case of a single-photon source and perfect detectors,
but also for the realistic case of a phase-randomized weak coherent light
source and imperfect threshold detectors. Our result on the phase error rate
upper bound is independent of the loss in the channel. Also, we compare the
three-state protocol with the BB84 protocol. For the single-photon source case,
our result proves that the BB84 protocol strictly tolerates a higher quantum
bit error rate than the three-state protocol; while for the coherent-source
case, the BB84 protocol achieves a higher key generation rate and secure
distance than the three-state protocol when a decoy-state method is used.Comment: 10 pages, 3 figures, 2 column
Properties of Ridges in Elastic Membranes
When a thin elastic sheet is confined to a region much smaller than its size
the morphology of the resulting crumpled membrane is a network of straight
ridges or folds that meet at sharp vertices. A virial theorem predicts the
ratio of the total bending and stretching energies of a ridge. Small strains
and curvatures persist far away from the ridge. We discuss several kinds of
perturbations that distinguish a ridge in a crumpled sheet from an isolated
ridge studied earlier (A. E. Lobkovsky, Phys. Rev. E. 53 3750 (1996)). Linear
response as well as buckling properties are investigated. We find that quite
generally, the energy of a ridge can change by no more than a finite fraction
before it buckles.Comment: 13 pages, RevTeX, acknowledgement adde
EXCESSIVE TIBIAL ROTATION IS RESTORED AFTER ANATOMICAL DOUBLE BUNDLE ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION
Recent studies suggested that tibial rotaion was not restored after single bundle anterior cruciate ligament (ACL) reconstruction. This study aimed to determine if excessive tibial rotation would be restored by anatomical double bundle ACL reconstruction. Ten male subjects with unilateral ACL injury were prospectively assessed with a high demanding task before and after ACL reconstruction. Knee kinematics during pivoting movement was measured by a motion analysis system. The tibial rotation was reduced in the reconstructed knee after ACL reconstruction than the deficient knee (
Struggling and juggling: a comparison of assessment loads in research and teaching-intensive universities
In spite of the rising tide of metrics in UK higher education, there has been scant attention paid to assessment loads, when evidence demonstrates that heavy demands lead to surface learning. Our study seeks to redress the situation by defining assessment loads and comparing them across research-and teaching intensive universities. We clarify the concept of ‘assessment load’ in response to findings about high volumes of summative assessment on modular degrees. We define assessment load across whole undergraduate degrees, according to four measures: the volume of summative assessment; volume of formative assessment; proportion of examinations to coursework; number of different varieties of assessment. All four factors contribute to the weight of an assessment load, and influence students’ approaches to learning. Our research compares programme assessment data from 73 programmes in 14 UK universities, across two institutional categories. Research-intensives have higher summative assessment loads and a greater proportion of examinations; teaching-intensives have higher varieties of assessment. Formative assessment does not differ significantly across both university groups. These findings pose particular challenges for students in different parts of the sector. Our study questions the wisdom that ‘more’ is always better, proposing that lighter assessment loads may make room for ‘slow’ and deep learning
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