2 research outputs found
Near-Infrared Dye-Conjugated Amphiphilic Hyaluronic Acid Derivatives as a Dual Contrast Agent for In Vivo Optical and Photoacoustic Tumor Imaging
Amphiphilic
hyaluronic acid (HA) derivatives bearing hydrophobic
indocyanine green dye derivatives and hydrophilic poly(ethylene glycol)
were synthesized through the use of condensation and copper-catalyzed
click cyclization reactions. The amphiphilic HA derivatives dissolved
in water and formed self-assemblies in which the near-infrared dyes
were tightly packed and arranged to form dimers or H-aggregates. By
irradiating an aqueous solution of HA derivatives with near-infrared
light, photoacoustic signals were detected along with fluorescence
emission. Self-assemblies consisting of HA derivatives could smoothly
accumulate in tumor tissues by passive tumor targeting. By utilizing
HA derivatives as a contrast agent, tumor sites were clearly visualized
by optical imaging as well as by photoacoustic tomography
Near-Infrared Dye-Conjugated Amphiphilic Hyaluronic Acid Derivatives as a Dual Contrast Agent for In Vivo Optical and Photoacoustic Tumor Imaging
Amphiphilic
hyaluronic acid (HA) derivatives bearing hydrophobic
indocyanine green dye derivatives and hydrophilic poly(ethylene glycol)
were synthesized through the use of condensation and copper-catalyzed
click cyclization reactions. The amphiphilic HA derivatives dissolved
in water and formed self-assemblies in which the near-infrared dyes
were tightly packed and arranged to form dimers or H-aggregates. By
irradiating an aqueous solution of HA derivatives with near-infrared
light, photoacoustic signals were detected along with fluorescence
emission. Self-assemblies consisting of HA derivatives could smoothly
accumulate in tumor tissues by passive tumor targeting. By utilizing
HA derivatives as a contrast agent, tumor sites were clearly visualized
by optical imaging as well as by photoacoustic tomography