Exogenous, but not Endogenous Nitric Oxide Inhibits Adhesion Molecule Expression in Human Endothelial Cells

Nitric oxide (NO) has many beneficial actions on the vascular wall including suppression of inflammation. The mechanism(s) by which NO antagonizes cytokine signaling are poorly understood, but are thought to involve inhibition of the pro-inflammatory transcription factor, NF-κB. NO represses nuclear translocation of NF-κB via the S-nitrosylation of its subunits which decreases the expression of target genes including adhesion molecules. In previous studies, we have shown that the intracellular location of endothelial nitric oxide synthase (eNOS) can influence the amount of NO produced and that NO levels are paramount in regulating the S-nitrosylation of target proteins. The purpose of the current study was to investigate the significance of subcellular eNOS to NF-κB signaling induced by pro-inflammatory cytokines in human aortic endothelial cells (HAECs). We found that in HAECs stimulated with TNFα, L-NAME did not influence the expression of intercellular adhesion molecule 1 (ICAM-1) or vascular cell adhesion molecular 1 (VCAM-1). In eNOS “knock down” HAECs reconstituted with either plasma membrane or Golgi restricted forms of eNOS, there was no significant effect on the activation of the NF-κB pathway over different times and concentrations of TNFα. Similarly, the endogenous production of NO did not influence the phosphorylation of IκBα. In contrast, higher concentrations of NO derived from the use of the exogenous NO donor, DETA NONOate, effectively suppressed the expression of ICAM-1/VCAM-1 in response to TNFα and induced greater S-nitrosylation of IKKβ and p65. Collectively these results suggest that neither endogenous eNOS nor eNOS location is an important influence on inflammatory signaling via the NF-κB pathway and that higher NO concentrations are required to suppress NF-κB in HAECs

TESS Delivers Its First Earth-sized Planet and a Warm Sub-Neptune

The future of exoplanet science is bright, as Transiting Exoplanet Survey Satellite (TESS) once again demonstrates with the discovery of its longest-period confirmed planet to date. We hereby present HD 21749b (TOI 186.01), a sub-Neptune in a 36 day orbit around a bright (V = 8.1) nearby (16 pc) K4.5 dwarf. TESS measures HD 21749b to be 2.61^(+0.17)_(-0.16) R⊕, and combined archival and follow-up precision radial velocity data put the mass of the planet at 22.7^(+2.2)_(-1.9) M⊕. HD 21749b contributes to the TESS Level 1 Science Requirement of providing 50 transiting planets smaller than 4 R⊕ with measured masses. Furthermore, we report the discovery of HD 21749c (TOI 186.02), the first Earth-sized (R_p = 0.892^(+0.064)_(-0.058)R⊕) planet from TESS. The HD 21749 system is a prime target for comparative studies of planetary composition and architecture in multi-planet systems

KELT-22Ab: A Massive, Short-Period Hot Jupiter Transiting a Near-solar Twin

We present the discovery of KELT-22Ab, a hot Jupiter from the KELT-South survey. KELT-22Ab transits the moderately bright (V∼11.1) Sun-like G2V star TYC 7518-468-1. The planet has an orbital period of P = 1.3866529±0.0000027 days, a radius of R_P = 1.285^(+0.12)_(−0.071) R_J, and a relatively large mass of M_P = 3.47^(+0.15)_(−0.14) M_J. The star has R⋆ = 1.099^(+0.079)_(−0.046) R⊙, M⋆ = 1.092^(+0.045)_(−0.041) M⊙, T_(eff) = 5767^(+50)_(−49) K, log g⋆ = 4.393^(+0.039)_(−0.060) (cgs), and [m/H] = +0.259^(+0.085)_(−0.083), and thus, other than its slightly super-solar metallicity, appears to be a near solar twin. Surprisingly, KELT-22A exhibits kinematics and a Galactic orbit that are somewhat atypical for thin disk stars. Nevertheless, the star is rotating quite rapidly for its estimated age, shows evidence of chromospheric activity, and is somewhat metal rich. Imaging reveals a slightly fainter companion to KELT-22A that is likely bound, with a projected separation of 6” (∼1400 AU). In addition to the orbital motion caused by the transiting planet, we detect a possible linear trend in the radial velocity of KELT-22A suggesting the presence of another relatively nearby body that is perhaps non-stellar. KELT-22Ab is highly irradiated (as a consequence of the small semi-major axis of a/R⋆ = 4.97), and is mildly inflated. At such small separations, tidal forces become significant. The configuration of this system is optimal for measuring the rate of tidal dissipation within the host star. Our models predict that, due to tidal forces, the semi-major axis of KELT-22Ab is decreasing rapidly, and is thus predicted to spiral into the star within the next Gyr

KELT-23Ab: A Hot Jupiter Transiting a Near-solar Twin Close to the TESS and JWST Continuous Viewing Zones

We announce the discovery of KELT-23Ab, a hot Jupiter transiting the relatively bright (V = 10.3) star BD+66 911 (TYC 4187-996-1), and characterize the system using follow-up photometry and spectroscopy. A global fit to the system yields host-star properties of T_(eff)=5900±49K, M∗=0.945^(+0.060)_(−0.054)M⊙, R∗=0.995±0.015R⊙, L∗=1.082^(+0.051)_(−0.048)L⊙, logg∗=4.418^(+0.026)_(−0.025) (cgs), and [Fe/H]=−0.105±0.077. KELT-23Ab is a hot Jupiter with a mass of MP=0.938^(+0.045)_(−0.042)M_J, radius of R_P=1.322±0.025RJ, and density of ρ_P=0.504^(+0.038)_(−0.035) g cm^(−3). Intense insolation flux from the star has likely caused KELT-23Ab to become inflated. The time of inferior conjunction is T_0=2458149.40776±0.00091 BJD_(TDB) and the orbital period is P=2.255353^(+0.000031)_(−0.00003) days. There is strong evidence that KELT-23A is a member of a long-period binary star system with a less luminous companion, and due to tidal interactions, the planet is likely to spiral into its host within roughly a gigayear. This system has one of the highest positive ecliptic latitudes of all transiting planet hosts known to date, placing it near the Transiting Planet Survey Satellite and James Webb Space Telescope continuous viewing zones. Thus we expect it to be an excellent candidate for long-term monitoring and follow up with these facilities

Global ecological success of Thalassoma fishes in extreme coral reef habitats

Phenotypic adaptations can allow organisms to relax abiotic selection and facilitate their ecological success in challenging habitats, yet we have relatively little data for the prevalence of this phenomenon at macroecological scales. Using data on the relative abundance of coral reef wrasses and parrotfishes (f. Labridae) spread across three ocean basins and the Red Sea, we reveal the consistent global dominance of extreme wave-swept habitats by fishes in the genus Thalassoma, with abundances up to 15 times higher than any other labrid. A key locomotor modification-a winged pectoral fin that facilitates efficient underwater flight in high-flow environments-is likely to have underpinned this global success, as numerical dominance by Thalassoma was contingent upon the presence of high-intensity wave energy. The ecological success of the most abundant species also varied with species richness and the presence of congeneric competitors. While several fish taxa have independently evolved winged pectoral fins, Thalassoma appears to have combined efficient high-speed swimming (to relax abiotic selection) with trophic versatility (to maximize exploitation of rich resources) to exploit and dominate extreme coral reef habitats around the world

TESS Delivers Its First Earth-sized Planet and a Warm Sub-Neptune

The future of exoplanet science is bright, as Transiting Exoplanet Survey Satellite (TESS) once again demonstrates with the discovery of its longest-period confirmed planet to date. We hereby present HD 21749b (TOI 186.01), a sub-Neptune in a 36 day orbit around a bright (V = 8.1) nearby (16 pc) K4.5 dwarf. TESS measures HD 21749b to be 2.61^(+0.17)_(-0.16) R⊕, and combined archival and follow-up precision radial velocity data put the mass of the planet at 22.7^(+2.2)_(-1.9) M⊕. HD 21749b contributes to the TESS Level 1 Science Requirement of providing 50 transiting planets smaller than 4 R⊕ with measured masses. Furthermore, we report the discovery of HD 21749c (TOI 186.02), the first Earth-sized (R_p = 0.892^(+0.064)_(-0.058)R⊕) planet from TESS. The HD 21749 system is a prime target for comparative studies of planetary composition and architecture in multi-planet systems

A Nearby M Star with Three Transiting Super-Earths Discovered by K2

Small, cool planets represent the typical end-products of planetary formation. Studying the architectures of these systems, measuring planet masses and radii, and observing these planets' atmospheres during transit directly informs theories of planet assembly, migration, and evolution. Here we report the discovery of three small planets orbiting a bright (K_s = 8.6 mag) M0 dwarf using data collected as part of K2, the new ecliptic survey using the re-purposed Kepler spacecraft. Stellar spectroscopy and K2 photometry indicate that the system hosts three transiting planets with radii 1.5–2.1 R_⊕, straddling the transition region between rocky and increasingly volatile-dominated compositions. With orbital periods of 10–45 days the planets receive just 1.5–10× the flux incident on Earth, making these some of the coolest small planets known orbiting a nearby star; planet d is located near the inner edge of the system's habitable zone. The bright, low-mass star makes this system an excellent laboratory to determine the planets' masses via Doppler spectroscopy and to constrain their atmospheric compositions via transit spectroscopy. This discovery demonstrates the ability of K2 and future space-based transit searches to find many fascinating objects of interest

Discovery of a White Dwarf Companion to HD 159062

We report on the discovery of a white dwarf companion to the nearby late G dwarf star, HD 159062. The companion is detected in 14 years of precise radial velocity (RV) data, and in high-resolution imaging observations. RVs of HD 159062 from 2003-2018 reveal an acceleration of $-13.3\pm0.12\ \rm{m s}^{-1}$, indicating that it hosts a companion with a long-period orbit. Subsequent imaging observations with the ShaneAO system on the Lick Observatory 3-meter Shane telescope, the PHARO AO system on the Palomar Observatory 5-meter telescope, and the NIRC2 AO system at the Keck II 10-meter telescope reveal a faint companion 2.7'' from the primary star. We performed relative photometry, finding $\Delta J = 10.09 \pm 0.38$ magnitudes, $\Delta K_{S} = 10.06 \pm 0.22$ magnitudes, and $\Delta L' = 9.67\pm0.08$ magnitudes for the companion from these observations. Analysis of the radial velocities, astrometry, and photometry reveals that the combined data set can only be reconciled for the scenario where HD 159062 B is a white dwarf. A full Bayesian analysis of the RV and imaging data to obtain the cooling age, mass, and orbital parameters of the white dwarf indicates that the companion is an old $M_{B} = 0.65^{+0.12}_{-0.04} M_{\odot}$ white dwarf with an orbital period of $P = 250^{+130}_{-76}$ years, and a cooling age of $\tau = 8.2^{+0.3}_{-0.5}$ Gyr.Comment: 10 pages, 9 figure

A TESS Dress Rehearsal: Planetary Candidates and Variables from K2 Campaign 17

We produce light curves for all ~34,000 targets observed with K2 in Campaign 17 (C17), identifying 34 planet candidates, 184 eclipsing binaries, and 222 other periodic variables. The forward-facing direction of the C17 field means follow-up can begin immediately now that the campaign has concluded and interesting targets have been identified. The C17 field has a large overlap with C6, so this latest campaign also offers an infrequent opportunity to study a large number of targets already observed in a previous K2 campaign. The timing of the C17 data release, shortly before science operations begin with the Transiting Exoplanet Survey Satellite (TESS), also lets us exercise some of the tools and methods developed for identification and dissemination of planet candidates from TESS. We find excellent agreement between these results and those identified using only K2-based tools. Among our planet candidates are several planet candidates with sizes <4 R⊕ and orbiting stars with Kp ≾ 10 (indicating good RV targets of the sort TESS hopes to find) and a Jupiter-sized single-transit event around a star already hosting a 6 day planet candidate

KELT-22Ab: A Massive, Short-Period Hot Jupiter Transiting a Near-solar Twin

We present the discovery of KELT-22Ab, a hot Jupiter from the KELT-South survey. KELT-22Ab transits the moderately bright (V∼11.1) Sun-like G2V star TYC 7518-468-1. The planet has an orbital period of P = 1.3866529±0.0000027 days, a radius of R_P = 1.285^(+0.12)_(−0.071) R_J, and a relatively large mass of M_P = 3.47^(+0.15)_(−0.14) M_J. The star has R⋆ = 1.099^(+0.079)_(−0.046) R⊙, M⋆ = 1.092^(+0.045)_(−0.041) M⊙, T_(eff) = 5767^(+50)_(−49) K, log g⋆ = 4.393^(+0.039)_(−0.060) (cgs), and [m/H] = +0.259^(+0.085)_(−0.083), and thus, other than its slightly super-solar metallicity, appears to be a near solar twin. Surprisingly, KELT-22A exhibits kinematics and a Galactic orbit that are somewhat atypical for thin disk stars. Nevertheless, the star is rotating quite rapidly for its estimated age, shows evidence of chromospheric activity, and is somewhat metal rich. Imaging reveals a slightly fainter companion to KELT-22A that is likely bound, with a projected separation of 6” (∼1400 AU). In addition to the orbital motion caused by the transiting planet, we detect a possible linear trend in the radial velocity of KELT-22A suggesting the presence of another relatively nearby body that is perhaps non-stellar. KELT-22Ab is highly irradiated (as a consequence of the small semi-major axis of a/R⋆ = 4.97), and is mildly inflated. At such small separations, tidal forces become significant. The configuration of this system is optimal for measuring the rate of tidal dissipation within the host star. Our models predict that, due to tidal forces, the semi-major axis of KELT-22Ab is decreasing rapidly, and is thus predicted to spiral into the star within the next Gyr