CHARACTERIZATION OF CHEMOKINE AND DENDRITIC CELL POPULATIONS IN PULMONARY GRANULOMAS FROM CYNOMOLGUS MACAQUESINFECTED WITH MYCOBACTERIUM TUBERCULOSIS

One-third of the world's population is infected with Mycobacterium tuberculosis, which causes over 2 million deaths annually. M. tuberculosis typically infects humans through the inhalation of aerosolized microorganisms and the host's immune system controls the infection by developing a granuloma, which consists predominantly of macrophages and lymphocytes. The factors initiating the formation and maintenance of these granulomas are not well understood, but immune cells are likely recruited to the site of inflammation to maintain immune control of the infection. Chemokines and cytokines play important roles in cell trafficking and migration of immune cells, and DC initiate an adaptive immune response. My hypothesis is that DC (in conjunction with macrophages) recruit immune cells to the granulomatous site by the expression of IFN-g-inducible chemokines, which are expressed due to mycobacterial antigen stimulation. To determine local cytokine- and chemokine-specific and DC-associated mRNA expression patterns in granulomatous lesions, I performed in situ hybridization (ISH) on paraformaldehyde-fixed, cryopreserved lung tissue sections obtained from cynomolgus macaques (Macaca fascicularis) infected with a low dose of virulent M. tuberculosis. In addition, we evaluated the presence of mycobacterial 16S rRNA to determine the distribution of the mycobacteria and the mycobacterial burden within the granulomas. To model the immune environment in the pulmonary granulomas, I infected human monocyte-derived DC with M. tuberculosis in the presence of IFN-g. Although I found an abundant expression of the IFN-g-inducible chemokines and numerous DC-associated genes within the granulomas, the IFN-g-inducible chemokine expression was predominantly produced by macrophages. The presence of DC in the granuloma may serve to skew the immune response to a type I environment, but our data do not suggest a direct role in the production of IFN-g-inducible chemokines. These studies provide further information on the potential roles for chemokines and DC in granuloma formation and maintenance as well as the composition of local DC populations. These studies further illustrate the complex microenvironment of granulomas, which are important in the control of tuberculosis infection. Further understanding of granuloma formation and maintenance could lead to the development of therapeutic treatments needed to reduce this public health epidemic

Development of Irrigation in Wasatch County

A primary basis for settlement locations in the great basin by the Mormons was the availability of water. The settlement of Heber Valley was no exception. Water became quickly involved in two important and determining factors (cooperation and self-reliance) in the development of Mormon society in general and Wasatch County\u27s society in particular. Likewise, these two factors influenced the direction in the development of water as it was utilized by the Mormons to establish the Kingdom of God on earth. Cooperation and self-reliance in Wasatch County were changed as modifications within the county were made as well as by other factors introduced in the county. Wasatch County farmers irrigation systems and institutions are today, a product of these two important factors and the modifications made on them. Co-operation and self reliance continue to be part of the agricultural way of life in Wasatch County

A Survey of Archeological and Historical Resources within the Bonneville Unit of the Central Utah Project

Four small archeological sites were found but were of insufficient significance to warrant their further study or preservation. Providing the enlargement of Deer Creek Reservoir represents the only alternative, a comprehensive study of the community and its historic resources has been recommended, especially as it relates to the use of land and water. In addition, study has been recommended of the settlement as it relates to the understanding of agricultural development in Utah

Charles Turley, Cindy Fuller, and Craig Hamilton in a Faculty Recital

This is the program for the faculty recital featuring baritone Charles Turley, pianist Cindy Fuller, and trumpet player Dr. Craig Hamilton. This recital took place on January 20, 2001, in the W. Francis McBeth Recital Hall

A Performing Arts Class Faculty Recital

This is the program for a Performing Arts Class faculty recital featuring the following faculty artists (in order of performance): trumpet player Craig Hamilton accompanied by pianist George Keck; soprano Cindy Fuller accompanied by pianist Diana Ellis; baritone Charlie Fuller accompanied by Cindy Fuller; soprano Diana Ellis accompanied by Cindy Fuller; and organist Russell Hodges. This recital took place on September 23, 1994, in the Mabee Fine Arts Center Recital Hall

Patrick Anthony Faircloth in a Senior Recital with the Ouachita Wind Ensemble

This is the program for the senior alto saxophone recital of Patrick Anthony Faircloth, who was accompanied by Cindy Fuller on the piano, and the Ouachita Wind Ensemble, directed by Dr. Craig V. Hamilton, held on February 6, 1996, in the Mabee Fine Arts Center Recital Hall

Theology, News and Notes - Vol. 52, No. 02

Theology News & Notes was a theological journal published by Fuller Theological Seminary from 1954 through 2014.https://digitalcommons.fuller.edu/tnn/1153/thumbnail.jp

Theology, News and Notes - Vol. 46, No. 02

Theology News & Notes was a theological journal published by Fuller Theological Seminary from 1954 through 2014.https://digitalcommons.fuller.edu/tnn/1136/thumbnail.jp