Senior Recital

Program listing performers and works performe

Wednesday Convocation

Program listing performers and works performe

Immune features that afford protection from clinical disease versus sterilizing immunity to Bordetella pertussis infection in a nonhuman primate model of whooping cough

The respiratory bacterial infection caused by Bordetella pertussis (whooping cough) is the only vaccine-preventable disease whose incidence has been increasing over the last 3 decades. To better understand the resurgence of this infection, a baboon animal model of pertussis infection has been developed. Naïve baboons that recover from experimental pertussis infection are resistant both to clinical disease and to airway colonization when re-challenged. In contrast, animals vaccinated with acellular pertussis vaccine and experimentally challenged do not develop disease, but airways remain colonized for 4-6 weeks. We explored the possibility that the IgG antibody response to pertussis infection is qualitatively different from antibodies induced by acellular pertussis vaccination. IgG was purified from pertussis-convalescent baboons shown to be resistant to pertussis disease and airway colonization. Purified IgG contained high titers to pertussis toxin, pertactin, and filamentous hemagglutinin. This pertussis-immune IgG or control IgG was passively transferred to naïve, juvenile baboons before experimental airway pertussis inoculation. The control animal that received normal IgG developed a typical symptomatic infection including leukocytosis, cough and airway colonization for 4 weeks. In contrast, baboons that received convalescent IgG maintained normal WBC counts and were asymptomatic. However, despite remaining asymptomatic, their airways were colonized for 4-6 weeks with B. pertussis. All animals developed IgG and IgA anti-pertussis antibody responses. Interestingly, the clearance of B. pertussis from airways coincided with the emergence of a serum anti-pertussis IgA response. These studies demonstrate that passive administration of pertussis-specific IgG from previously infected animals can prevent clinical disease but does not affect prolonged airway colonization with B. pertussis. This outcome is similar to that observed following acellular pertussis vaccination. Understanding immune mechanisms—other than IgG—that are capable of preventing airway colonization with B. pertussis will be critical for developing more effective vaccines to prevent whooping cough

Honors Convocation

List of performers and performances

Wednesday Convocation

List of performers and performances

Wednesday Convocation

Program listing performers and works performe

Junior Recital

List of performers and performances

Unpacking "Ideas" in Creative Work: A Multidisciplinary Review

New ideas are central to a wide array of organizational phenomena and research that involve creativity and innovation. Yet, there is little consensus on what the concept of ‘ideas’ means, with a broad range of creative outputs being conceptualized as ideas. This fragmentation makes it challenging to compare studies and build a cumulative base of knowledge. To integrate different streams of organizational research and develop a framework for categorizing and understanding ideas, we reviewed papers across creativity, innovation, entrepreneurship, design, knowledge creation, and network studies. We propose a wave-particle duality framework for understanding and integrating two distinct approaches to studying ideas

Successful climate services for adaptation: What we know, don't know and need to know

The success of climate services for adaptation to climate change is increasingly studied, but there exists a varying understanding of what climate services are and what makes them successful. This study systematically mapped the breadth and depth of peer-reviewed literature on the subject and synthesized evidence on what we know, don't know and need to know about successful climate services. The study focusses on services that are based on long-term climate information or aim to inform decision-making on longer time scales and includes papers that inform on success, including evaluation studies, empirical investigations in the factors and practices that influence success, and conceptual discussions on what constitutes success. Results show that insights on climate service success are scattered and most often originate from western and developed countries. Conceptualizations of success in the literature are diverse and focus on processes for production and use, product characteristics and process elements of the service itself, and/or on contextual factors. Studies that assess the results of climate services tend to focus on evaluating (perceived) usability, though uptake, impacts and outcomes of services are rarely assessed systematically. Frequently reported success factors include brokering functions, user-producer interactions and iterative and flexible development processes. To be successful, services themselves should be contextualized and tailored to the user and its decision-making context. We conclude that whilst context emerges as a critical determinant of success, the configuration of factors and processes leading to success demand further investigation

Contrast-Enhanced Microtomographic Characterisation of Vessels in Native Bone and Engineered Vascularised Grafts Using Ink-Gelatin Perfusion and Phosphotungstic Acid

Bone ischemia and necrosis are challenging to treat, requiring investigation of native and engineered bone revascularisation processes through advanced imaging techniques. This study demonstrates an experimental two-step method for precise bone and vessel analysis in native bones or vascularised bone grafts using X-ray microtomography (; μ; CT), without interfering with further histological processing.; Distally ligated epigastric arteries or veins of 6 nude rats were inserted in central channels of porous hydroxyapatite cylinders and these pedicled grafts were implanted subcutaneously. One week later, the rats were perfused with ink-gelatin and euthanised and the femurs, tibias, and grafts were explanted. Samples were scanned using; μ; CT, decalcified, incubated with phosphotungstic acid (PTA) for contrast enhancement, rescanned, and processed histologically.; Contrast-enhanced; μ; CT displayed the course and branching of native bone vessels. Histologically, both central (-17%) and epiphyseal vessels (-58%) appeared smaller than in; μ; CT scans. Hydroxyapatite cylinders were thoroughly vascularised but did not display bone formation. Grafts with a central artery had more (+58%) and smaller (-52%) vessel branches compared to grafts with a vein.; We present a relatively inexpensive and easy-to-perform two-step method to analyse bone and vessels by; μ; CT, suitable to assess a variety of bone-regenerative strategies