Search for Tetraneutron by Pion Double Charge Exchange Reaction at J-PARC

Tetraneutron ($^4n$) has come back in the limelight, because of recent observation of a candidate resonant state at RIBF. We propose to investigate the pion double charge exchange (DCX) reaction, i.e. $^4\mathrm{He}({\pi}^- , {\pi}^+)$, as an alternative way to populate tetraneutron. An intense ${\pi}^-$ beam with the kinetic energy of ~850 MeV, much higher than that in past experiments at LAMPF and TRIUMF, will open up a possibility to improve the experimental sensitivity of the formation cross section, which will be much smaller than hitherto known DCX cross sections such as $^9\mathrm{Be}({\pi}^-, {\pi}^+)^9\mathrm{He}\ (g.s.)$.Comment: 4 pages, 1 figure; proceedings of the 14th International Conference on Meson-Nucleon Physics and the Structure of the Nucleon (MENU2016), Kyoto, Japan, 25-30 July 201

An asymptotic analysis for an integrable variant of the Lotka-Volterra prey-predator model via a determinant expansion technique

Abstract: The Hankel determinant appears in representations of solutions to several integrable systems. An asymptotic expansion of the Hankel determinant thus plays a key role in the investigation of asymptotic analysis of such integrable systems. This paper presents an asymptotic expansion formula of a certain Casorati determinant as an extension of the Hankel case. This Casorati determinant is then shown to be associated with the solution to the discrete hungry Lotka-Volterra (dhLV) system, which is an integrable variant of the famous prey-predator model in mathematical biology. Finally, the asymptotic behavior of the dhLV system is clarified using the expansion formula for the Casorati determinant

Inducible colitis-associated glycome capable of stimulating the proliferation of memory CD4+ T cells

Immune responses are modified by a diverse and abundant repertoire of carbohydrate structures on the cell surface, which is known as the glycome. In this study, we propose that a unique glycome that can be identified through the binding of galectin-4 is created on local, but not systemic, memory CD4+ T cells under diverse intestinal inflammatory conditions, but not in the healthy state. The colitis-associated glycome (CAG) represents an immature core 1–expressing O-glycan. Development of CAG may be mediated by down-regulation of the expression of core-2 β1,6-N-acetylglucosaminyltransferase (C2GnT) 1, a key enzyme responsible for the production of core-2 O-glycan branch through addition of N-acetylglucosamine (GlcNAc) to a core-1 O-glycan structure. Mechanistically, the CAG seems to contribute to super raft formation associated with the immunological synapse on colonic memory CD4+ T cells and to the consequent stabilization of protein kinase C θ activation, resulting in the stimulation of memory CD4+ T cell expansion in the inflamed intestine. Functionally, CAG-mediated CD4+ T cell expansion contributes to the exacerbation of T cell–mediated experimental intestinal inflammations. Therefore, the CAG may be an attractive therapeutic target to specifically suppress the expansion of effector memory CD4+ T cells in intestinal inflammation such as that seen in inflammatory bowel disease

Interaction between Leptospiral Lipopolysaccharide and Toll-like Receptor 2 in Pig Fibroblast Cell Line, and Inhibitory Effect of Antibody against Leptospiral Lipopolysaccharide on Interaction

Leptospiral lipopolysaccharide (L-LPS) has shown potency in activating toll-like receptor 2 (TLR2) in pig fibroblasts (PEFs_NCC1), and causes the expression of proinflammatory cytokines. However, the stimulation by L-LPS was weak eliciting the function of TLR2 sufficiently in pig innate immunity responses during Leptospira infection. In this study, the immune response of pig embryonic fibroblast cell line (PEFs_SV40) was investigated and was found to be the high immune response, thus TLR2 is the predominate receptor of L-LPS in pig cells. Further, we found a strategy using the antibody against L-LPS, to prevent L-LPS interaction with TLR2 in pig cells which could impact on immune activation

帯行列の固有値を計算する離散可積分系について

九州大学応用力学研究所研究集会報告 No.21ME-S7 「非線形波動研究の現状と将来 : 次の10 年への展望」RIAM Symposium No.21ME-S7 Current and Future Research on Nonlinear Waves : Perspectives for the Next Decade離散可積分系に分類される離散ハングリーロトカ・ボルテラ系及び離散ハングリー戸田方程式の時間発展は，あるクラスの帯行列の相似変形を与える。この性質を利用して定式化された帯行列の固有値計算アルゴリズムを紹介する

Efficacy and safety of micafungin in empiric and D-index-guided early antifungal therapy for febrile neutropenia ; A subgroup analysis of the CEDMIC trial

Objectives: The D-index is defined as the area over the neutrophil curve during neutropenia. The CEDMIC trial confirmed the noninferiority of D-index-guided early antifungal therapy (DET) using micafungin to empirical antifungal therapy (EAT). In this study, we evaluated the efficacy and safety of micafungin in these settings. Methods: From the CEDMIC trial, we extracted 67 and 113 patients who received micafungin in the DET and EAT groups, respectively. Treatment success was defined as the fulfilment of all components of a five-part composite end point. Fever resolution was evaluated at seven days after the completion of therapy. Results: The proportion of high-risk treatments including induction chemotherapy for acute leukemia and allogeneic hematopoietic stem cell transplantation was significantly higher in the DET group than in the EAT group (82.1% vs. 52.2%). The efficacy of micafungin was 68.7% (95%CI: 56.2–79.4) and 79.6% (71.0–86.6) in the DET and EAT groups, respectively. When we focused on high-risk treatments, the efficacy was 69.1% (55.2–80.9%) and 78.0% (65.3–87.7%), respectively (P = 0.30). There was no significant difference in any of the 5 components between the two groups. Conclusions: The efficacy of micafungin in patients undergoing high-risk treatment was not strongly impaired in DET compared to that in EAT

箱に番号が付いた新しい箱玉系について

九州大学応用力学研究所研究集会報告 No.25AO-S2 「非線形波動研究の拡がり」Reports of RIAM Symposium No.25AO-S2 The breadth and depth of nonlinear wave scienceProceedings of a symposium held at Chikushi Campus, Kyushu Universiy, Kasuga, Fukuoka, Japan, October 31 - November 2, 2013離散ハングリー戸田方程式の超離散版は玉に番号が付いた箱玉系の運動方程式として知られている．本報告では，離散ハングリー戸田方程式のある変形版を導入し，その超離散化を通じて箱を番号付けで区別した新しい箱玉系を導く．また，離散ハングリー戸田方程式の変形版の保存量を求め，その超離散化によって新しい箱玉系の保存量を明らかにする．保存量を求める過程において，離散ハングリーロトカ・ボルテラ系と離散ハングリー戸田方程式の変形版を結ぶベックルント変換も示す．さらに，玉に番号が付いた箱玉系と新しい箱玉系の関係についても述べる