H1821+643: The most X-ray and infrared luminous AGN in the Swift/BAT survey in the process of rapid stellar and supermassive black hole mass assembly

H1821+643 is the most X-ray luminous non-beamed AGN of $L_\mathrm{14-150 keV}= 5.2\times 10^{45}$ erg s$^{-1}$ in the Swift/BAT ultra-hard X-ray survey and it is also a hyper-luminous infrared (IR) galaxy $L_\mathrm{IR} = 10^{13.2} L_\odot$ residing in the center of a massive galaxy cluster, which is a unique environment achieving the rapid mass assembly of black holes (BH) and host galaxies in the local universe. We decompose the X-ray to IR spectral energy distribution (SED) into the AGN and starburst component using the SED fitting tool CIGALE-2022.0 and show that H1821+643 consumes a large amount of cold gas ($\dot{M}_\mathrm{con}$) with star-formation rate of $\log ( \mathrm{SFR}/M_{\odot}~\mathrm{yr}^{-1}) = 3.01 \pm 0.04$ and BH accretion rate of $\log (\dot{M}_\mathrm{BH}/M_{\odot}~\mathrm{yr}^{-1}) = 1.20 \pm 0.05$. This high $\dot{M}_\mathrm{con}$ is larger than the cooling rate ($\dot{M}_\mathrm{cool}$) of the intra-cluster medium (ICM), $\dot{M}_\mathrm{con}/\dot{M}_\mathrm{cool} \gtrsim 1$, which is one to two order magnitude higher than the typical value of other systems, indicating that H1821 provides the unique and extreme environment of rapid gas consumption. We also show that H1821+643 has an efficient cooling path achieving from $10^7$ K to $10^2$ K thanks to [OIII] 63 $\mu \mathrm{m}$, which is a main coolant in low temperature range ($10^4$ K to $10^2$ K) with a cooling rate of $\dot{M}_{\mathrm{cool}}=3.2\times 10^5\ M_{\odot}\mathrm{~yr^{-1}}$, and the star-forming region extends over 40 kpc scale.Comment: 20 pages, 8 figures, accepted for publication in Ap

J1406+0102: Dust Obscured Galaxy Hiding Super Eddington Accretion System with Bright Radio Emission

Recent high-$z$ quasar observations strongly indicate that super-Eddington accretion is a crucial phase to describe the existence of supermassive black holes (SMBHs) with $M_\mathrm{BH} \gtrsim 10^9 M_\odot$ at $z \gtrsim 7$. Motivated by the theoretical suggestion that the super-Eddington phase efficiently produces outflows and jets bright in radio bands, we search and find a super-Eddington radio-loud dust-obscured galaxy (DOG) J1406+0102 at $z=0.236$, through cross-matching of the infrared-bright DOGs of Noboriguchi et al. (2019) with the VLA/FIRST 1.4 GHz radio and the SDSS optical spectral catalog. DOG J1406+0102 shows broad components in the Balmer lines. Assuming those lines are from the broad line region, it gives BH mass estimation of $\log\ (M_\mathrm{BH}/M_\odot)=7.30 \pm 0.25$, and AGN luminosity of $\log (L_\mathrm{bol,[OIII]}/\mathrm{erg}~\mathrm{s}^{-1}) = 45.91\pm0.38$ estimated from the intrinsic [OIII] luminosity, resulting in super-Eddington accretion of $\lambda_\mathrm{Edd}\simeq 3$. We show that 1) DOG J1406+0102 is operating strong AGN feedback: the [OIII] outflow velocity exceeds the escape velocity of the host galaxy halo and the kinetic efficiency is obtained as $\approx$ 8% that can be sufficient to quench the host galaxy, 2) the expected future growth pathway of DOG J1406+0102 would join an over-massive BH trajectory and 3) radio-loud DOGs can provide a significant contribution to the high-energy ($\gtrsim$ 100 TeV) cosmic neutrino background if we assume DOG J1406+0102 as a representative of radio-loud DOGs.Comment: 10 pages, 5 figures, submitted to ApJ

Lignosulfonate Rapidly Inactivates Human Immunodeficiency and Herpes Simplex Viruses

Background: Very few studies of the antiviral potential of lignosulfonates have been published. With the aim of oral application, among various groups of natural products, the relative antiviral potency of lignosulfonate and its ability to rapidly inactivate viruses were investigated. Methods: As target cells, MT-4 cells in suspension and attached Vero cells were used for infections with human immunodeficiency virus (HIV) and human herpes simplex type-1 virus (HSV). Mock- or virus-infected cells were incubated for 3–5 days with various concentrations of test samples, and the viable cell number was determined with the MTT method. For the shorter exposure experiments, higher titers of HIV or HSV were exposed to test samples for 10 or 3 min, diluted to a normal multiplicity of infection (MOI), and applied to the cells. Antiviral activity was quantified by using the chemotherapy index. Results: In the long-exposure system, lignosulfonates showed comparable anti-HIV activity with those of AZT, ddC, and sulfated polysaccharides, and it exceeded those of hundreds of tannins and flavonoids. When the exposure time was shortened, the chemotherapeutic index of the lignosulfonates for HIV was increased 27-fold. At a physiological pH, lignosulfonate showed higher anti-HIV activity than commercial alkali-lignin, dealkali-lignin, and humic acid, possibly due to the higher solubility and purity. Conclusions: With their rapid virus-inactivation capabilities, lignosulfonates may be useful for the prevention or treatment of virally induced oral diseases