Dimeth­yl(2-oxo-2-phenyl­eth­yl)sulfanium bromide

Single crystals of the title compound, C10H13OS+·Br−, were obtained from ethyl acetate/ethyl ether after reaction of acetophenone with hydro­bromic acid and dimethyl­sulfoxide. The carbonyl group is almost coplanar with the neighbouring phenyl ring [O—C—C—C = 178.9 (2)°]. The sulfanium group shows a trigonal–pyramidal geometry at the S atom. The crystal structure is stabil­ized by C—H⋯Br hydrogen-bonding inter­actions. Weak π–π inter­actions link adjacent phenyl rings [centroid–centroid distance = 3.946 (2) Å]

Simulation analysis of crack cause of concrete overflow dam for Hadashan Hydro Project by 3-D FEM

AbstractThis paper is mainly to study the cracking reasons for concrete overflow dam of Hadashan Hydro Project. The three-dimensional finite element method (3-D FEM) is developed to simulation analysis the temperature and thermal stress distribution in the concrete overflow dam during the construction period. The results show that the crack of the concrete overflow dam is temperature crack, mainly due to the combined action of the internal thermal gradient and the external restraints; and dramatic changes in ambient temperature exacerbate cracking of early-age concrete. Finally, the results are applied to provide some references for the construction in the related fields

Numerical modeling of the horizontal flow and concentration distribution of nitrogen within a stored-paddy bulk in a large warehouse: Poster

The insect population in grain stores can be kept under control by maintaining a high concentration of N<sub>2</sub> gas throughout the grain bed. The development of controlled atmosphere storage technology for insect control requires an accurate prediction of the distribution of introduced gases in bulk grain. In this paper, based on the convective-diffusion model, the horizontal flow of N<sub>2</sub>, which was introduced into the paddy bulk in a large warehouse by means of the horizontal ventilation system, are modeled as fluid flow in a porous medium. The experimental data for N<sub>2</sub> transfer and flow through ducts and bulk paddy were used to validate the model. The equations were solved using the finite difference method, and the predictions from the proposed model were in good agreement with the experimental results. The concentration distribution and flow uniformity of nitrogen in stored paddy were also analyzed during the nitrogen-filling procedure for CA storage. It was shown that it is feasible and practical to introduce nitrogen into stored bulk grain in a large warehouse by means of the horizontal ventilation system.The insect population in grain stores can be kept under control by maintaining a high concentration of N<sub>2</sub> gas throughout the grain bed. The development of controlled atmosphere storage technology for insect control requires an accurate prediction of the distribution of introduced gases in bulk grain. In this paper, based on the convective-diffusion model, the horizontal flow of N<sub>2</sub>, which was introduced into the paddy bulk in a large warehouse by means of the horizontal ventilation system, are modeled as fluid flow in a porous medium. The experimental data for N<sub>2</sub> transfer and flow through ducts and bulk paddy were used to validate the model. The equations were solved using the finite difference method, and the predictions from the proposed model were in good agreement with the experimental results. The concentration distribution and flow uniformity of nitrogen in stored paddy were also analyzed during the nitrogen-filling procedure for CA storage. It was shown that it is feasible and practical to introduce nitrogen into stored bulk grain in a large warehouse by means of the horizontal ventilation system

PO-089 Effects of 6-days nitrate supplementation on [Ca2+] and CRT in skeletal muscle of exhausted rats

Objective There are many active ingredients in sports nutrition, and nitrate is gradually being valued by sports nutrition and product developers. Supplementation of nitrate is a practical method to increase circulating plasma nitrite, thereby increasing NO bioavailability. However, the existing research has rarely reported the dose effect between nitrate supplementation and changes in exercise efficiency and capacity. The mechanism of action of nitrate is not fully understood yet. The aim of this study was to analyze the effects of different doses of nitrate on the exercise capacity of rats, as well as the detection of [Ca2+] and calreticulin (CRT) expression in the gastrocnemius, soleus and extensor digitorum longus, trying to figure out the effects of different doses of nitrate supplementation on calcium homeostasis in different types of muscle fibers. Methods 40 SD rats (8-week-old) weighing 270-290 grams were randomly divided into control group (C group, 8), exercise control group (EC group, 8), exercise with low-dose supplementation group (ELN group, 8), exercise with medium-dose supplementation group (EMN group, 8) and exercise with high-dose supplementation group (EHN group, 8). Sodium nitrate was used as exogenous nitrate for oral gavage. The intragastric concentration was 0.3 mmol/day/kg body weight in the ELN group, 0.7 mmol/day/kg body weight in the EMN group, and 1.0 mmol/day/kg body weight in the EHN group. The others were orally administered with normal saline. All exercise groups (EC, ELN, EMN and EHN) underwent 3 days adaptive low-intensity treadmill training with slope 0°, speed 16 meter/min, and the time is 5 min, 10 min and 15 min incrementally. 24 hours after the end of the last gavage, a one-time exhaustion treadmill experiment was started. The running platform slope was -16°, the speed was 16 meter/min. Exhaustive experiment participants were not aware of the grouping of rats. Immediately after the end of exhaustive exercise, the rats were weighed and anesthetized with sodium pentobarbital solution. Blood is collected for testing [NO2-]. The gastrocnemius, soleus and extensor digitorum longus were collected for testing NOS activity, tissue [Ca2+] and CRT expression. Results (1) Compared with the EC group, the exhaustion time of the other exercise groups was prolonged. The exhaustion time of the EMN group was very significantly prolonged from that of the EC group (P<0.01). The exhaustion time of the EMN group was significantly prolonged from that of the EC group (P< 0.05). At the same time, the difference between the EMN group and the ELN group was statistically significant (P<0.05). (2) Serum [NO2-] in the supplemented nitrate groups (ELN, EMN and EHN) was higher than that in the EC group, and the difference was statistically significant (P<0.01). The serum [NO2-] in different groups (ELN, EMN and EHN) raised with the increase of nitrate concentration, and the difference between each adjacent concentration group was statistically significant (P<0.05). (3) In the gastrocnemius, soleus and extensor digitorum longus respectively, there were no significant differences in TNOS, iNOS and cNOS activities between the groups (P>0.05). (4) In the gastrocnemius, compared with the EC group, the [Ca2+] (P<0.05) and CRT expression (P<0.05) in the EMN group were significantly decreased. There was no difference between the ELN vs EC group (P>0.05) and the EHN vs EC group (P>0.05). (5) In the soleus, the [Ca2+] (P<0.05) and CRT expression (P<0.05) in the EMN group were significantly decreased. There was no difference between the ELN vs EC group (P>0.05) and the EHN vs EC group (P>0.05). (6) In the extensor digitorum longus, compared with the EC group, the [Ca2+] (P<0.05) and CRT expression (P<0.05) in the EHN group were significantly decreased. There was no difference between ELN and EC group (P>0.05). The expression of CRT in EMN group was significantly decreased (P<0.05), but there is no difference of [Ca2+] between EMN and EC group (P<0.05). Conclusions (1) 6-day sodium nitrate supplementation is a reliable method to increase serum [NO2-] concentration. (2) 6-day sodium nitrate supplementation can prolong the duration of one-time exhaustive exercise in rats, and the dose of 0.7mmol/kg/d is the best. (3) Sodium nitrate supplementation can affect the [Ca2+] and the expression of CRT in skeletal muscle after one-time exhaustive exercise. Different concentrations of sodium nitrate have different effects on different types of muscle fibers

BTG2 suppresses renal cell carcinoma progression through N6-methyladenosine

The biological functions of N6-methyladenosine (m6A) modification of mRNA have recently received a great deal of attention. In previous studies, m6A methylation modification has been shown to regulate mRNA fate and to be crucial for the progression and development of tumors. BTG2 (B-cell translocation gene 2) is a member of BTG/TOB anti-proliferative protein family. BTG2 could inhibit cell proliferation and migration and regulate the cell cycle progression. In this study, we confirm that BTG2 is frequently down-regulated in renal cell carcinoma (RCC) tissues and its low expression is associated with unfavorable prognosis and decreased m6A level. Moreover, we found that m6A methylation modifies the 5’UTR of BTG2 to promote its mRNA stability by binding to IGF2BP2. It has been shown that CRISPR/dCas13b-METLL3 can specifically increase BTG2 m6A modification to significantly increase its m6A and expression levels. Then m6A hypermethylation in BTG2 mRNA could dramatically inhibit RCC cells proliferation and migration, and induce cells apoptosis. Taken together, our data show that BTG2 functions as a tumor suppressor and is frequently silenced via m6A modification in RCC

A web-based appointment system to reduce waiting for outpatients: A retrospective study

<p>Abstract</p> <p>Background</p> <p>Long waiting times for registration to see a doctor is problematic in China, especially in tertiary hospitals. To address this issue, a web-based appointment system was developed for the Xijing hospital. The aim of this study was to investigate the efficacy of the web-based appointment system in the registration service for outpatients.</p> <p>Methods</p> <p>Data from the web-based appointment system in Xijing hospital from January to December 2010 were collected using a stratified random sampling method, from which participants were randomly selected for a telephone interview asking for detailed information on using the system. Patients who registered through registration windows were randomly selected as a comparison group, and completed a questionnaire on-site.</p> <p>Results</p> <p>A total of 5641 patients using the online booking service were available for data analysis. Of them, 500 were randomly selected, and 369 (73.8%) completed a telephone interview. Of the 500 patients using the usual queuing method who were randomly selected for inclusion in the study, responses were obtained from 463, a response rate of 92.6%. Between the two registration methods, there were significant differences in age, degree of satisfaction, and total waiting time (<it>P </it>< 0.001). However, gender, urban residence, and valid waiting time showed no significant differences (<it>P </it>> 0.05). Being ignorant of online registration, not trusting the internet, and a lack of ability to use a computer were three main reasons given for not using the web-based appointment system. The overall proportion of non-attendance was 14.4% for those using the web-based appointment system, and the non-attendance rate was significantly different among different hospital departments, day of the week, and time of the day (<it>P </it>< 0.001).</p> <p>Conclusion</p> <p>Compared to the usual queuing method, the web-based appointment system could significantly increase patient's satisfaction with registration and reduce total waiting time effectively. However, further improvements are needed for broad use of the system.</p

Effect of PWHT on the Carbon Migration and Mechanical Properties of 2205DSS-Q235 LBW Joint

The effect of postweld heat treatment (PWHT) on the carbon migration and mechanical properties of the 2205DSS-Q235 laser beam welding (LBW) joint was investigated. The carbon-rich zone (CRZ) and carbon-depleted zone (CDZ) generated at the welding seam/Q235 (WS-Q235) interface as the carbon migration occurred after heat-treated at 600°C, 700°C, and 800°C for 1 h. The softening was found in the CDZ. Only the CRZ in joints heat-treated at 800°C was hardened because of the retaining of high-carbon untempered martensite. The thick CDZ in joints heat-treated at 700°C and 800°C contributed to the tensile fracture and the low elongation. The strength of the joint was roughly determined by the hardness of the fracture zone

Deep Learning Nonhomogeneous Elliptic Interface Problems by Soft Constraint Physics-Informed Neural Networks

It is a great challenge to solve nonhomogeneous elliptic interface problems, because the interface divides the computational domain into two disjoint parts, and the solution may change dramatically across the interface. A soft constraint physics-informed neural network with dual neural networks is proposed, which is composed of two separate neural networks for each subdomain, which are coupled by the connecting conditions on the interface. It is beneficial to capture the singularity of the solution across the interface. We formulate the PDEs, boundary conditions, and jump conditions on the interface into the loss function by means of the physics-informed neural network (PINN), and the different terms in the loss function are balanced by optimized penalty weights. To enhance computing efficiency for increasingly difficult issues, adaptive activation functions and the adaptive sampled method are used, which may be improved to produce the optimal network performance, as the topology of the loss function involved in the optimization process changes dynamically. Lastly, we present many numerical experiments, in both 2D and 3D, to demonstrate the proposed method’s flexibility, efficacy, and accuracy in tackling nonhomogeneous interface issues

A Special Multigrid Strategy on Non-Uniform Grids for Solving 3D Convection–Diffusion Problems with Boundary/Interior Layers

Boundary or interior layer problems of high-dimensional convection–diffusion equations have distinct asymmetry. Consequently, computational grid distributions and linear algebraic systems arising from finite difference schemes for them are also asymmetric. Numerical solutions for these kinds of problems are more complicated than those symmetric problems. In this paper, we extended our previous work on the partial semi-coarsening multigrid method combined with the high-order compact (HOC) difference scheme for solving the two-dimensional (2D) convection–diffusion problems on non-uniform grids to the three-dimensional (3D) cases. The main merit of the present method is that the multigrid method on non-uniform grids can be performed with a different number of grids in different coordinate axes, which is more efficient than the multigrid method on non-uniform grids with the same number of grids in different coordinate axes. Numerical experiments are carried out to validate the accuracy and efficiency of the present method. It is shown that, without losing the high precision, the present method is very effective to reduce computing cost by cutting down the number of grids in the direction(s) which does/do not contain boundary or interior layer(s)