Rho-GEF Soloによるアクチン繊維と中間径フィラメントの制御とメカノセンシングにおける機能

要約のみTohoku University水野健作課

Pauli-blocking Effect in a Quark Model

Pauli-Blocking effect on the kinetic term is investigated by employing the quark cluster model. The effect can be understood by the change of the degrees of the mixing between the incoming wave and the 0$\ell$ state of the inter-cluster wave function, which can be expressed by a potential which is highly nonlocal. We look into the properties of this effect by comparing equivalent local potentials. In the channel where the Pauli-blocking effect is small, the on-shell equivalent local potential simulates the nonlocal potential well even for the off-shell behavior. On the other hand, the off-shell behavior is very different from the original one where the effect is large. This off-shell behavior, however, can well be simulated by considering the nonlocal matrix elements only between the $0s$ state and the other states. The energy dependent potentials are also constructed and found to be helpful to understand the energy dependence of the effect.Comment: 14 pages, 12 figure

Crystal structure of lipoate-protein ligase A from Escherichia coli : Determination of the lipoic acid-binding site

This research was originally published in Journal of Biological Chemistry. Kazuko Fujiwara, Sachiko Toma, Kazuko Okamura-Ikeda, Yutaro Motokawa, Atsushi Nakagawa and Hisaaki Taniguchi. Crystal structure of lipoate-protein ligase A from Escherichia coli : Determination of the lipoic acid-binding site. Journal of Biological Chemistry. 2005; 280, 33645-33651. © the American Society for Biochemistry and Molecular Biology

Spin-Orbit Force of Instanton-Induced Interaction in Strange and Charmed Systems

Effects of the spin orbit-force on hadronic systems with strangeness or charm are investigated by a valence quark model with the instanton-induced interaction. By introducing this interaction, the spin-orbit splittings in the negative-parity hyperons becomes 0.14 -- 0.37 times smaller. The flavor-octet baryon mass spectrum and the splittings in the charmed baryons become consistent with the experiments. Though the splitting is also reduced in the flavor-singlet baryons, it still gives two third of the experimental value. The reduction comes from the cancellation between the one-gluon exchange and the instanton-induced interaction, which is channel-specific. In most of the two-baryon channels, the symmetric and antisymmetric spin-orbit force of the YN interaction remains strong after introducing this instanton effect. A few exceptional channels, however, are found where the cancellation affects strongly and the spin-orbit force becomes small.Comment: 22 pages & 2 figure

Perceptions of Self of Persons

Not much is known about the self-perceptions of persons using prosthetic devices. The purpose of the literature review was to explore the self-perceptions of persons living with visible artificial devices from published articles between 2010 and 2017. Using key words to search for published literature in the PubMed, CINAHL, IEEE Proceedings, and Scopus indices showed 680 articles. Braun and Clarke's six phases of qualitative thematic analysis were used on 25 articles meeting the inclusion criteria, revealing 29 data extracts (themes) as data summaries. Three key thematic categories were revealed : Body image and ownership, integration of prosthetic device into the self-body, and suspended enjoyment or delight, reflecting the longings for completeness affecting persons' use of prosthetic devices. Consistent with self-perceptions understood through social biases and customs, completeness is achieved through the happy paradox of a person made whole through artificial devices. This experience informs nursing practice in helping people find meaning in their life. Further research into self-perceptions with prosthetic devices is essential, particularly those reflecting the cultural influences of artificial devices on quality of life

Thermal neutron flux evaluation by a single crystal CVD diamond detector in LHD deuterium experiment

The single crystal CVD diamond detector (SDD) was installed in the torus hall of the Large Helical Device (LHD) to measure neutrons with high time resolution and neutron energy resolution. The LiF foil with 95.62 % of 6Li isotope enrichment pasted on the detector was used as the thermal neutron convertor as the energetic ions of 2.0 MeV alpha and 2.7 MeV triton particles generated in LiF foil and deposited the energy into SDD. SDD were exposed to the neutron field in the torus hall of the LHD during the 2nd campaign of the deuterium experiment. The total pulse height in SDD was linearly propotional to the neutron yield in a plasma operation in LHD over 4 orders of magnitude. The energetic alpha and triton were separately measured by SDD with LiF with the thickness of 1.9 μm, although SDD with LiF with the thickness of 350 μm showed a broadened peak due to the large energy loss of energetic particles generated in the bulk of LiF. The modeling with MCNP and PHITS codes well interpreted the pulse height spectra for SDD with LiF with different thicknesses. The results above demonstrated the sufficient time resolution and energy discrimination of SDD used in this work

Prediction of outcome of patients with oral squamous cell carcinoma using vascular invasion and the strongly positive expression of vascular endothelial growth factors.

Vascular invasion and lymph node metastasis have been used as histopathological prognosticators of cancers including oral squamous cell carcinoma (OSCC). In addition to metastatic potential via blood vessels, tumor-induced angiogenesis might also be associated with prognosis. However, the efficacy of combined evaluation of vascular invasion and angiogenesis-associated molecules for the prognosis of OSCC remains obscure. This is also the case in lymph node metastasis and lymphovasculogenesis-associated molecules. The aim of this study was to examine factors related to prognosis to improve the accuracy of prognostic prediction of OSCC using vasculogenesis-associated markers. Ninety specimens of patients from 1991 to 2002 with previously untreated OSCC, who underwent either biopsy or surgery, were histopathologically and immunohistochemically analyzed using antibodies for vascular endothelial growth factor (VEGF)-A, VEGF-C, cyclooxygenase (COX)-2 and Midkine. The ninety cases were composed of 72 well-differentiated, 12 moderately differentiated and 6 poorly differentiated OSCC. Efficient models of prognostic prediction were evaluated by extensive statistical analyses. The presence of vascular invasion or lymph node metastasis was confirmed to be significantly associated with poor prognosis in the univariate analysis. Multivariate logic regression analysis suggested that patients with the strongly positive expression of either VEGF-A or VEGF-C had a significant association with poor prognosis even in patients without vascular invasion and in early-stage patients. Neither COX-2 nor Midkine contributed to predict the prognosis of the patients. The strongly positive expression of VEGF-A or VEGF-C was suggested to reinforce the histopathological diagnosis of vascular invasion and improve the accuracy and efficacy of prognostic prediction of OSCC