わが国の経済連携協定の進展と自由貿易体制への貢献

departmental bulletin pape

Study on administration of 1,5-anhydro-D-fructose in C57BL/6J mice challenged with high-fat diet

1,5-Anhydro-D-fructose (AF) is a mono-saccharide directly formed from starch and glycogen by the action of α-1,4-glucan lyase (EC 4.2.2.13). Our previous study has indicated that AF increases glucose tolerance and insulin secretion in NMRI mice after administration through a gastric gavage in a single dose at 150 mg per mouse. In this study, we used high-fat feeding of C57BL/6J mice to examine the influence of long-term administration of AF on glucose-stimulated insulin secretion in vivo and in vitro. We found that 8-weeks of high-fat feeding increased body weight, fasting blood glucose and insulin levels in C57BL/6J mice when compared to mice fed normal diet. Impaired glucose tolerance was also observed in mice receiving 8-weeks of high-fat diet. In contrast, AF (1.5 g/kg/day), administered through drinking water for 8-weeks, did not affect body weight or food and water intake in mice fed either the high-fat or normal diet. There was no difference in basal blood glucose or insulin levels between AF-treated and control group. Oral glucose tolerance test (OGTT) showed that AF did not affect glucose-stimulated insulin secretion in mice. In in vitro studies with isolated islets, AF did not influence glucose-stimulated insulin secretion in mice receiving either high-fat or normal diet. We therefore conclude that when given through drinking water for 8 weeks at 1.5 g/kg/day, AF has no effect on glucose-stimulated insulin secretion in C57BL/6J mice challenged with a high-fat diet

The Cosmic-Ray Composition between 2 PeV and 2 EeV Observed with the TALE Detector in Monocular Mode

We report on a measurement of the cosmic-ray composition by the Telescope Array Low-energy Extension (TALE) air fluorescence detector (FD). By making use of the Cherenkov light signal in addition to air fluorescence light from cosmic-ray (CR)-induced extensive air showers, the TALE FD can measure the properties of the cosmic rays with energies as low as ∼2 PeV and exceeding 1 EeV. In this paper, we present results on the measurement of distributions of showers observed over this energy range. Data collected over a period of ∼4 yr were analyzed for this study. The resulting distributions are compared to the Monte Carlo (MC) simulated data distributions for primary cosmic rays with varying composition and a four-component fit is performed. The comparison and fit are performed for energy bins, of width 0.1 or 0.2 in, spanning the full range of the measured energies. We also examine the mean value as a function of energy for cosmic rays with energies greater than 1015.8 eV. Below 1017.3 eV, the slope of the mean as a function of energy (the elongation rate) for the data is significantly smaller than that of all elements in the models, indicating that the composition is becoming heavier with energy in this energy range. This is consistent with a rigidity-dependent cutoff of events from Galactic sources. Finally, an increase in the elongation rate is observed at energies just above 1017 eV, indicating another change in the cosmic-ray composition

Observation of variations in cosmic ray single count rates during thunderstorms and implications for large-scale electric field changes

We present the first observation by the Telescope Array Surface Detector (TASD) of the effect of thunderstorms on the development of cosmic ray single count rate intensity over a 700 km2 area. Observations of variations in the secondary low-energy cosmic ray counting rate, using the TASD, allow us to study the electric field inside thunderstorms, on a large scale, as it progresses on top of the 700 km2 detector, without dealing with the limitation of narrow exposure in time and space using balloons and aircraft detectors. In this work, variations in the cosmic ray intensity (single count rate) using the TASD, were studied and found to be on average at the ~(0.5-1)% and up to 2% level. These observations were found to be both in excess and in deficit. They were also found to be correlated with lightning in addition to thunderstorms. These variations lasted for tens of minutes; their footprint on the ground ranged from 6 km to 24 km in diameter and moved in the same direction as the thunderstorm. With the use of simple electric field models inside the cloud and between cloud to ground, the observed variations in the cosmic ray single count rate were recreated using CORSIKA simulations. Depending on the electric field model used and the direction of the electric field in that model, the electric field magnitude that reproduces the observed low-energy cosmic ray single count rate variations was found to be approximately between 0.2 GV-0.4 GV. This in turn allows us to get a reasonable insight on the electric field and its effect on cosmic ray air showers inside thunderstorms

Measurement of the proton-air cross section with Telescope Array\u27s Black Rock Mesa and Long Ridge fluorescence detectors, and surface array in hybrid mode

Ultrahigh energy cosmic rays provide the highest known energy source in the Universe to measure proton cross sections. Though conditions for collecting such data are less controlled than an accelerator environment, current generation cosmic ray observatories have large enough exposures to collect significant statistics for a reliable measurement for energies above what can be attained in the laboratory. Cosmic ray measurements of cross section use atmospheric calorimetry to measure depth of air shower maximum (Xmax), which is related to the primary particle\u27s energy and mass. The tail of the Xmax distribution is assumed to be dominated by showers generated by protons, allowing measurement of the inelastic proton-air cross section. In this work, the proton-air inelastic cross section measurement, σp-airinel, using data observed by Telescope Array\u27s Black Rock Mesa and Long Ridge fluorescence detectors and surface detector array in hybrid mode is presented. σp-airinel is observed to be 520.1±35.8[Stat]-42.9+25.3[Sys] mb at s=73 TeV. The total proton-proton cross section is subsequently inferred from Glauber formalism and is found to be σpptot=139.4-21.3+23.4[Stat]-25.4+15.7[Sys] mb

First High-Speed Video Camera Observations of a Lightning Flash Associated With a Downward Terrestrial Gamma-Ray Flash

In this paper, we present the first high-speed video observation of a cloud-to-ground lightning flash and its associated downward-directed Terrestrial Gamma-ray Flash (TGF). The optical emission of the event was observed by a high-speed video camera running at 40,000 frames per second in conjunction with the Telescope Array Surface Detector, Lightning Mapping Array, interferometer, electric-field fast antenna, and the National Lightning Detection Network. The cloud-to-ground flash associated with the observed TGF was formed by a fast downward leader followed by a very intense return stroke peak current of −154 kA. The TGF occurred while the downward leader was below cloud base, and even when it was halfway in its propagation to ground. The suite of gamma-ray and lightning instruments, timing resolution, and source proximity offer us detailed information and therefore a unique look at the TGF phenomena