245 research outputs found
Određivanje naboja teških čestica kozmičkog zračenja pomoću brojanja δ–zraka u fuji ET–7B nuklearnoj emulziji
The range distribution of δ–rays produced by heavy nuclei of energy ≈ 5 GeV/n in Fuji ET–7B nuclear emulsion has been investigated using data from an exposure to primary cosmic rays in a balloon–borne plastic–emulsion chamber. The estimated δ–ray densities per 100 µm for projectiles of charges Z = 14, 20 and 26 are in accord with the low–range simulation results of Ichimura et al.Eksperimentalni podaci o raspodjeli gustoće δ–zraka na energijama iznad 15 keV uspoređeni su s rezultatima simulacijskog programa koji je razvio Ichimura sa suradnicima za čestice sa Z = 14, 20 i 26
The Pathogenic Factors from Oral Streptococci for Systemic Diseases
The oral cavity is suggested as the reservoir of bacterial infection, and the oral and pharyngeal biofilms formed by oral bacterial flora, which is comprised of over 700 microbial species, have been found to be associated with systemic conditions. Almost all oral microorganisms are non-pathogenic opportunistic commensals to maintain oral health condition and defend against pathogenic microorganisms. However, oral Streptococci, the first microorganisms to colonize oral surfaces and the dominant microorganisms in the human mouth, has recently gained attention as the pathogens of various systemic diseases, such as infective endocarditis, purulent infections, brain hemorrhage, intestinal inflammation, and autoimmune diseases, as well as bacteremia. As pathogenic factors from oral Streptococci, extracellular polymeric substances, toxins, proteins and nucleic acids as well as vesicles, which secrete these components outside of bacterial cells in biofilm, have been reported. Therefore, it is necessary to consider that the relevance of these pathogenic factors to systemic diseases and also vaccine candidates to protect infectious diseases caused by Streptococci. This review article focuses on the mechanistic links among pathogenic factors from oral Streptococci, inflammation, and systemic diseases to provide the current understanding of oral biofilm infections based on biofilm and widespread systemic diseases
Is the progression of treatment for patients with hemophilia leading to improvements in school or social life?: A questionnaire survey for mothers of children or adolescents who chiefly receive prophylactic treatment for hemophilia.
【背景】血友病患者の治療は進歩した。そこで治療の進歩による患者の学校・社会生活の詳細を明らかにするために,母親を対象に,若年世代の患者の学校・社会生活,母親の困り事について実態調査した。
【方法】血友病患者の母親を対象に,無記名自記式の質問紙調査を実施した。
【結果】母親27人の回答が得られ,息子である患者は30人だった。定期輸注実施は23人で,そのうち家庭で輸注を行う者は22人だった。通園経験のある者は27人だった。全ての行事に参加させた者が18人だった。宿泊行事中の定期輸注の実施について,中学生までは学校に支援依頼していた。患者8人は自己注射し,高校生以降の患者4人は,自室で一人の時に注射をしたという回答だった。母親の困り事は「血管確保の失敗と焦り」だった。
【結論】治療の進歩は患者の学校・社会生活を改善した。しかし継続的治療を支える家族の負担のもとに成立する。今後必要な医療支援として,患者の宿泊行事中の輸注において,患者が安心して注射できる場所についての助言が示された。Background: Hemostatic treatment for patients with hemophilia( PWH) has improved. The aim of this study was to clarify school status and social life among young boys with hemophilia, as well as their mothers’ frustrations.
Methods: A questionnaire survey was completed anonymously by mothers of hemophilic boys.
Results: A total of 27 mothers of 30 PWHs completed the survey. Twenty-three PWHs had received prophylactic treatment, and 22 received home infusion therapy. Twenty-seven PWHs had attended preschool, and 18 had participated in all preschool/school events. When factor concentrates needed to be infused during overnight events, many mothers requested the assistance of medical staff until the PWHs were junior high school students. When they were high school students, eight PWHs were able to infuse themselves. Four PWHs were reported to infuse alone, hiding from the public eye. Mothers’ chief source of frustration was“ infusion failure on busy mornings.”
Conclusion: This study indicates that the progress of treatment for PWHs may improve the school or social life of patients. However, these patients’ family support is also essential for the patients’ treatment. Medical support, such as advice about where to self-infuse during overnight events is needed for PWHs
A case of refractory cutaneous polyarteritis nodosa in a patient with hepatitis B carrier status successfully treated with tumor necrosis factor alpha blockade
Development of diffuse large B-cell lymphoma in a patient with Waldenström's macroglobulinemia/lymphoplasmacytic lymphoma: clonal identity between two B-cell neoplasms
Waldenström's macroglobulinemia (WM)/ lymphoplasmacytic lymphoma (LPL) is an indolent mature B-cell neoplasm. In rare cases of WM/LPL, diffuse large B-cell lymphoma (DLBCL) develops as a result of histologic transformation. In this report, we present a case of DLBCL developing in a patient with WM/LPL. Combination chemotherapy for DLBCL was effective and complete remission was eventually achieved. We attempted to determine the clonal relatedness between WM/LPL and DLBCL in the patient by analyzing complementarity-determining region 3 (CDR3) in the immunoglobulin heavy chain gene. A common CDR3 sequence was found in tumor cells of DLBCL and those of WM/LPL, indicating that tumor cells of DLBCL are clonally identical to those of WM/LPL. Therefore, in the present case, DLBCL is developed from WM/LPL cells by clonal evolution
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