Strategies and Controversies in the Treatment With Carbon Dioxide Laser of Laryngeal Hemangioma: A Case Series and Review of the Literature

The hemangioma is the most common vascular tumor, involving the head and neck in 60% of cases. It is rare in the larynx. In children, hemangiomas are more frequent on the subglottis, whereas in adults the most common site is the supraglottis. Laryngeal hemangioma with cavernous features isolated to the free edge of the vocal fold is a very rare clinical finding. We present 2 cases of glottic hemangioma. Both patients reported severe hoarseness

Downregulation of praja2 restrains endocytosis and boosts tyrosine kinase receptors in kidney cancer

Abstract Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer in the adult population. Late diagnosis, resistance to therapeutics and recurrence of metastatic lesions account for the highest mortality rate among kidney cancer patients. Identifying novel biomarkers for early cancer detection and elucidating the mechanisms underlying ccRCC will provide clues to treat this aggressive malignant tumor. Here, we report that the ubiquitin ligase praja2 forms a complex with-and ubiquitylates the AP2 adapter complex, contributing to receptor endocytosis and clearance. In human RCC tissues and cells, downregulation of praja2 by oncogenic miRNAs (oncomiRs) and the proteasome markedly impairs endocytosis and clearance of the epidermal growth factor receptor (EGFR), and amplifies downstream mitogenic and proliferative signaling. Restoring praja2 levels in RCC cells downregulates EGFR, rewires cancer cell metabolism and ultimately inhibits tumor cell growth and metastasis. Accordingly, genetic ablation of praja2 in mice upregulates RTKs (i.e. EGFR and VEGFR) and induces epithelial and vascular alterations in the kidney tissue. In summary, our findings identify a regulatory loop between oncomiRs and the ubiquitin proteasome system that finely controls RTKs endocytosis and clearance, positively impacting mitogenic signaling and kidney cancer growth

TROIS QUARTS D'HEURE DE TANGOS-SUCCES AVEC JACQUES CAHAN ET SON ORCHESTRE / Jacques CAHAN et son Orchestre typique

Titre uniforme : [Lisboa antigua = Adieu Lisbonne]Titre uniforme : [C'est bon d'aimer]Comprend : J'AI TROP AIME / J. GADE - TRAHISON / GOMEZ - C'EST BON D'AIMER / GOMEZ - ADIEU, MON PAYS / Tito FUGGI - LISBOA ANTIGA / R. PORTELA - PRIERE PERUVIENNE / GOMERA - CZARDAS TANGO / R. BROWN - TU ME CONNAISSAIS MAL / J. CANA - COEURS SOLITAIRES / C.H. VIC - GUITARA MIA / MARIOTTI - VOYAGE A ROME / J. CAHAN - TU DANSAIS SI BIEN / J. CANA - JOLIE BRUYERE / P.J. HANSEN - LA CALESITA / M. MORES - TANGO MUSETTE / A. VERCHUREN et Jo MOUTET - TANGOI BLANC / M. PHILIPPE-GERARD et TILCHEBnF-Partenariats, Collection sonore - BelieveContient une table des matière

Surprise-partie n °23

Titre uniforme : [La complainte de la Butte]Titre uniforme : [L'homme et l'enfant]Titre uniforme : [La strada (Musique de film)]. ExtraitTitre uniforme : [Mambo italiano]Comprend : JE CHERCHE MON AMOUR, fox / AZNAVOUR ; l'orch. Jerry MENGO - L'HOMME ET L'ENFANT, fox / W. SHANKLIN ; l'orch. Jacques BRIENNE - SOURCES BLEUES, boléro / TRENET ; l'orch. Roger BOURDIN - LA STRADA, boléro / N. ROTA ; l'orch. Jo MOUTET - GRICEL, tango / M. MORES ; l'orch. J. MORINO - CUARTITO AZUL, tango / M. MORES ; l'orch. J. MORINO - COMPLAINTE DE LA BUTTE, valse / G. van PARYS ; l'orch. Michel RAMOS - SI TU M'AIMAIS, valse / G. van PARYS ; l'orch. Michel RAMOS - PRIERE PERUVIENNE, baion / J. GOMERA ; l'orch. Pépé LUIZ - OH MAMA, baion / Pia del MORO ; l'orch. Pépé LUIZ - SUR MA VIE, slow / C. AZNAVOUR ; l'orch. Jerry MENGO - APRES L'AMOUR, slow / C. AZNAVOUR ; l'orch. Jerry MENGO - JOUE POUR MOI, tango / MISRAKI ; l'orch. Tito FUGGI - BALLADE DES BALADINS, tango / G. BECAUD ; l'orch. Tito FUGGI - EL CHA CHA, mambo / R. CASAS ; l'orch. Pépé LUIZ - MAMBO ITALIANO / B. MERRIL ; l'orch. Pépé LUIZBnF-Partenariats, Collection sonore - BelieveContient une table des matière

Surprise-partie N °21

Titre uniforme : [Un jour tu verras]Titre uniforme : [Una lagrima tuya]Comprend : UN JOUR TU VERRAS, slow / G. van PARYS ; l'orch. Jacques BRIENNE - JE T'AIME COMME CA, slow / J. DAVIS ; l'orch. Jacques BRIENNE - ZUT ET FLUTE, baion / H. CORDOVIL, M. VIEIRA ; l'orch. Roger BOURDIN - BIG CHIEF : baion / S. BECHET ; l'orch. Roger BOURDIN - ELEMBRUJO DE GRANADA, paso-doble / MONREAL ; l'orch. Pépé LUIZ - PASO ORIENTAL, paso-doble / VERSCHUREN ; l'orch. Pépé LUIZ - SLOW FOX 22 / M. MAGNE ; l'orch. Michel MAGNE - RIVE GAUCHE, medium / N. CHIBOUST ; l'orch. Noël CHIBOUST - QUAND LES BONGOS, guaracha / J. LEDRU ; l'orch. Pépé LUIZ - TOI, mambo / F. VERAN ; l'orch. Yvon ALAIN - CHANGEZ DE CAVALIERE, valse / L. COLEMAN ; l'orch. Michel RAMOS - QUAND MARIA CHANTAIT, valse / P. DURAND ; l'orch. Michel RAMOS - J'AI DORMI AVEC LE PRINTEMPS, tango / SPIERS ; l'orch. Tito FUGGI - UNA LAGRIMA TUYA, tango / MORES ; l'orch. Jacques MORINO - PARIS CHERI, fox / F. LOPEZ ; l'orch. Fred GERARD - CA ME DEMANGE, fox / J. DAVIS ; l'orch. Fred GERARDBnF-Partenariats, Collection sonore - BelieveContient une table des matière