686 research outputs found
How best to market a crowdsourced product?
In the old days, companies developed products for their customers.
The idea that the customer would have any role in the process beyond
expressing a particular colour or flavour preference seemed unthinkable.
Henry Ford supposedly said that if he had asked people what
they wanted, they would have said, a faster horse. Today, more and
more companies have concluded that Ford was too pessimistic and
that customers actually have a lot of imagination
From Dynkin diagram symmetries to fixed point structures
Any automorphism of the Dynkin diagram of a symmetrizable Kac-Moody algebra
induces an automorphism of the algebra and a mapping between its highest weight
modules. For a large class of such Dynkin diagram automorphisms, we can
describe various aspects of these maps in terms of another Kac-Moody algebra,
the `orbit Lie algebra'. In particular, the generating function for the trace
of the map on modules, the `twining character', is equal to a character of the
orbit Lie algebra. Orbit Lie algebras and twining characters constitute a
crucial step towards solving the fixed point resolution problem in conformal
field theory.Comment: Latex, 60 pages (extended version 63 pages), 4 uuencoded figures
Formula (6.25) corrected. While this correction might be important in
applications of our work, the results of the paper are not affected by it. In
the present submission the "extended version" is default. In this version the
corrected formula is (6.32
From non-semisimple Hopf algebras to correlation functions for logarithmic CFT
We use factorizable finite tensor categories, and specifically the
representation categories of factorizable ribbon Hopf algebras H, as a
laboratory for exploring bulk correlation functions in local logarithmic
conformal field theories. For any ribbon Hopf algebra automorphism omega of H
we present a candidate for the space of bulk fields and endow it with a natural
structure of a commutative symmetric Frobenius algebra. We derive an expression
for the corresponding bulk partition functions as bilinear combinations of
irreducible characters; as a crucial ingredient this involves the Cartan matrix
of the category. We also show how for any candidate bulk state space of the
type we consider, correlation functions of bulk fields for closed oriented
world sheets of any genus can be constructed that are invariant under the
natural action of the relevant mapping class group.Comment: 41 pages, several figures. version 2: typos corrected, bibliography
updated, introduction extended, a few minor clarifications adde
Customer empowerment in new product development
Companies have traditionally taken responsibility for
deciding what products and product innovations are offered
to customers. However, a growing number of companies are
turning this relationship on its head by asking customers not
only for help in creating new products, but also in deciding
which ones should be produced
Topological defects for the free boson CFT
Two different conformal field theories can be joined together along a defect
line. We study such defects for the case where the conformal field theories on
either side are single free bosons compactified on a circle. We concentrate on
topological defects for which the left- and right-moving Virasoro algebras are
separately preserved, but not necessarily any additional symmetries. For the
case where both radii are rational multiples of the self-dual radius we
classify these topological defects. We also show that the isomorphism between
two T-dual free boson conformal field theories can be described by the action
of a topological defect, and hence that T-duality can be understood as a
special type of order-disorder duality.Comment: 43 pages, 4 figure
Guidelines for choosing between multi-item and single-item scales for construct measurement: A predictive validity perspective
Establishing predictive validity of measures is a major concern in marketing research. This paper investigates the conditions favoring the use of single items versus multi-item scales in ter
The fusion algebra of bimodule categories
We establish an algebra-isomorphism between the complexified Grothendieck
ring F of certain bimodule categories over a modular tensor category and the
endomorphism algebra of appropriate morphism spaces of those bimodule
categories. This provides a purely categorical proof of a conjecture by Ostrik
concerning the structure of F.
As a by-product we obtain a concrete expression for the structure constants
of the Grothendieck ring of the bimodule category in terms of endomorphisms of
the tensor unit of the underlying modular tensor category.Comment: 16 page
Test of the semischematic model for a liquid of linear molecules
We apply to a liquid of linear molecules the semischematic mode-coupling
model, previously introduced to describe the center of mass (COM) slow dynamics
of a network-forming molecular liquid. We compare the theoretical predictions
and numerical results from a molecular dynamics simulation, both for the time
and the wave-vector dependence of the COM density-density correlation function.
We discuss the relationship between the presented analysis and the results from
an approximate solution of the equations from molecular mode-coupling theory
[R. Schilling and T. Scheidsteger, Phys. Rev. E 56 2932 (1997)].Comment: Revtex, 10 pages, 4 figure
Refractory and relapsed paediatric ACC in the MET studies – a challenging situation necessitating novel diagnostic and therapeutic concepts
Background
Paediatric adrenocortical carcinomas (ACC) are highly aggressive malignancies with a dismal prognosis in advanced and metastatic disease. Little is known about outcome of patients with refractory and relapsed (r/r) disease.
Procedure
National retrospective multicentre study including r/r ACC diagnosed in patients aged <18 years registered in the MET studies between January 1997 and December 2021
Results
A total of 16 patients (5 male; median age 12.9 years) with refractory disease were included. Median time to progression was 0.6 years [0.0-1.3]. Site of progression was locoregional (n=1), distant (n=3), and combined (n=12). 3-year overall (OS) and progression-free (PFS) survival were both 0%.
Thirty patients with relapse (11 male; median age 7.3 years) were identified. Median time to relapse was 0.7 years [0.1-3.2]. Site of relapse was locoregional (n=8), distant (n=15), and combined (n=7). At last follow-up, 20 patients had died of disease or complications or were alive with disease, 10 patients were in second complete remission (median follow-up: 6.8 years [0-10.5]). 3-year OS and PFS following relapse were 39.1% and 31.9%. Survival was superior in patients with distant relapse (59.6%) compared to locoregional (28.6%) and combined (14.3%) (p=0.028) and in patients with complete surgical resection of all sites of recurrence (70.0%) compared to incomplete (21.4%) and no surgery (0%) (p=0.003).
Conclusions
For patients nonresponsive to first-line therapy or who experience relapse, prognosis is dismal and options are scarce. Site of relapse and resectability define prognosis. Novel therapeutic concepts are needed to improve the outcome of paediatric patients with r/r ACC
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