Research on User Resistance Behavior in the Post-Implementation Stage of a Hospital Information System

The development of informatization brings great opportunities for the construction of informatization in hospitals. Hospitals are increasingly dependent on information systems. However, in the process of implementing the hospital information system, user resistance has become an important factor hindering the successful implementation of the system. The existing researches on the causes of user resistance mostly stay in the pre-implementation stage before the introduction of the system. However, the pre-implementation stage does not involve the resistance caused by users\u27 real contact with the system, so the research conclusions are limited. Based on the existing three-factor resistance theory, choosing the resistance in the postimplementation stage of a hospital information system as case study object, starting from the three theoretical perspectives, this paper makes a comprehensive analysis of the reasons for the resistance behavior in the post-implementation stage of the information system, and puts forward that the reasons for the resistance behavior are caused by user motivation, system development technology, network infrastructure, organizational support, organizational management, and other comprehensive caused by multiple factors. Through this study, the conclusions of the existing information system resistance factors research field are further expanded and improved, making the conclusions more comprehensive and specific. This paper not only provides theoretical reference for researchers in related fields, but also provides substantive suggestions for the smooth implementation of information system in hospitals, promotes the transformation of hospital informatization, and improves the level of medical service and social health

2,2-Dichloro-1-(2-phenyl-1,3-oxazolidin-3-yl)ethanone

In the title mol­ecule, C11H11Cl2NO2, the oxazolidine ring is in an envelope conformation with the O atom forming the flap; the other four essentially planar ring atoms (r.m.s. deviation = 0.012 Å) form a dihedral angle of 91.1 (3)° with the phenyl ring. In the crystal structure, mol­ecules are linked by weak inter­molecular C—H⋯O hydrogen bonds, forming one-dimensional chains

Mathematical Model to Predict Preheating Time and Temperature Profile in Boxed-Heart Square Timber during Preheating

The objective of this study was to develop a two-dimensional mathematical model that can beused to calculate the heat transfer in larch boxed-heart square timber during the preheating process. The preheating time obtained with the calculations agreed with the experimental results. Both experiments and calculations indicated that it took about 6.5 h for the center of the timbers (120 mm thick 120 mm wide) to reach ambient temperature, suggesting that the model can be used to accurately estimate preheating times. During the preheating process, the simulated core temperature of the wood agreed with the experimental result. However, for the remaining locations, the relative error was rather large, with the value first increasing and then decreasing with time. Therefore, the model can only be used to accurately estimate temperature at the core region of the wood. Furthermore, the results suggested that MC had no significant effect on preheating time

The juxtamembrane and carboxy-terminal domains of Arabidopsis PRK2 are critical for ROP-induced growth in pollen tubes.

Polarized growth of pollen tubes is a critical step for successful reproduction in angiosperms and is controlled by ROP GTPases. Spatiotemporal activation of ROP (Rho GTPases of plants) necessitates a complex and sophisticated regulatory system, in which guanine nucleotide exchange factors (RopGEFs) are key components. It was previously shown that a leucine-rich repeat receptor-like kinase, Arabidopsis pollen receptor kinase 2 (AtPRK2), interacted with RopGEF12 for its membrane recruitment. However, the mechanisms underlying AtPRK2-mediated ROP activation in vivo are yet to be defined. It is reported here that over-expression of AtPRK2 induced tube bulging that was accompanied by the ectopic localization of ROP-GTP and the ectopic distribution of actin microfilaments. Tube depolarization was also induced by a potentially kinase-dead mutant, AtPRK2K366R, suggesting that the over-expression effect of AtPRK2 did not require its kinase activity. By contrast, deletions of non-catalytic domains in AtPRK2, i.e. the juxtamembrane (JM) and carboxy-terminal (CT) domains, abolished its ability to affect tube polarization. Notably, AtPRK2K366R retained the ability to interact with RopGEF12, whereas AtPRK2 truncations of these non-catalytic domains did not. Lastly, it has been shown that the JM and CT domains of AtPRK2 were not only critical for its interaction with RopGEF12 but also critical for its distribution at the plasma membrane. These results thus provide further insight into pollen receptor kinase-mediated ROP activation during pollen tube growth

1,4-Diazo­niabicyclo­[2.2.2]octane diaqua­dichlorido­(oxalato-κ2 O,O′)iron(III) chloride

In the title compound, (C6H14N2)[Fe(C2O4)Cl2(H2O)2]Cl, all ions are situated on twofold rotational axes. The FeIII ion is coordinated by two O atoms from a chelating oxalate ligand, two water mol­ecules and two chloride anions in a distorted octa­hedral geometry. Inter­molecular N—H⋯O, O—H⋯O and O—H⋯Cl hydrogen bonds form an extensive three-dimensional network which consolidates the crystal packing

Localization of U(1)U(1) gauge field by non-minimal coupling with gravity

In this paper, we investigate the localization of the $U(1)$ gauge field on Randall-Sundrum-like braneworld models. The localization of the $U(1)$ gauge field is important because it plays a fundamental role in the branworld theories. To achieve the localization, we propose a novel action with a non-minimal coupling between the $U(1)$ gauge field and gravity. We find that the mass spectrum of the gauge field is continuous, without any gap between the zero-mass mode and the massive modes, and except for the zero-mass mode all the massive modes are not localized on the brane. Furthermore, the massive modes have negative squared masses, indicating they are tachyonic. Our analysis can be applied to a wide range of thin and thick braneworld scenarios, provided that the five-dimensional spacetime is asymptotically anti-de Sitter.Comment: 10 pages, 2 figures, Accepted by JCA

Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer.

Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution. Here, we sequence a unique cohort of multiple synchronous lung cancers (MSLCs) to determine the relative diversity and uniformity of genetic drivers upon identical germline and environmental background. We find that each multicentric primary tumor harbors distinct oncogenic alterations, including novel mutations that are experimentally demonstrated to be functional and therapeutically targetable. However, functional studies show a strikingly constrained tumorigenic pathway underlying heterogeneous genetic variants. These results suggest that although the mutation-specific routes that cells take during oncogenesis are stochastic, genetic trajectories may be constrained by selection for functional convergence on key signaling pathways. Our findings highlight the robust evolutionary pressures that simultaneously shape the expansion and constraint of genomic diversity, a principle that holds important implications for understanding tumor evolution and optimizing therapeutic strategies.Across cancer types tumor heterogeneity has been observed, but how this relates to tumor evolution is unclear. Here, the authors sequence multiple synchronous lung cancers, highlighting the evolutionary pressures that simultaneously shape the expansion and constraint of genomic heterogeneity