An Iterative Co-Saliency Framework for RGBD Images

As a newly emerging and significant topic in computer vision community, co-saliency detection aims at discovering the common salient objects in multiple related images. The existing methods often generate the co-saliency map through a direct forward pipeline which is based on the designed cues or initialization, but lack the refinement-cycle scheme. Moreover, they mainly focus on RGB image and ignore the depth information for RGBD images. In this paper, we propose an iterative RGBD co-saliency framework, which utilizes the existing single saliency maps as the initialization, and generates the final RGBD cosaliency map by using a refinement-cycle model. Three schemes are employed in the proposed RGBD co-saliency framework, which include the addition scheme, deletion scheme, and iteration scheme. The addition scheme is used to highlight the salient regions based on intra-image depth propagation and saliency propagation, while the deletion scheme filters the saliency regions and removes the non-common salient regions based on interimage constraint. The iteration scheme is proposed to obtain more homogeneous and consistent co-saliency map. Furthermore, a novel descriptor, named depth shape prior, is proposed in the addition scheme to introduce the depth information to enhance identification of co-salient objects. The proposed method can effectively exploit any existing 2D saliency model to work well in RGBD co-saliency scenarios. The experiments on two RGBD cosaliency datasets demonstrate the effectiveness of our proposed framework.Comment: 13 pages, 13 figures, Accepted by IEEE Transactions on Cybernetics 2017. Project URL: https://rmcong.github.io/proj_RGBD_cosal_tcyb.htm

Targeted PI3K/AKT/mTOR therapy for metastatic carcinomas of the cervix: A phase I clinical experience.

BackgroundActivated PI3K/AKT/mTOR pathway frequently occurs in metastatic or recurrent cervical carcinomas. However, the clinical benefits of matched therapy, a therapeutic approach targeting a specific mutational abnormality, have not yet been established.MethodsWe analyzed the outcomes of patients with metastatic or recurrent cervical carcinomas who had a test for PIK3CA mutation and/or PTEN loss/mutation, and received ≥1 phase I therapeutic regimen between January 2006 and June 2013.ResultsPatients with adenocarcinoma had fewer PIK3CA mutations (14%), and survived longer (median, 14.2 months) than those with squamous cell carcinoma (48% and 7.2 months; p = 0.016, and 0.001, respectively). Matched therapy targeting the activated PI3K/AKT/mTOR pathway led to a favorable rate of SD ≥ 6 months/CR/PR (53%) and significantly longer progression-free survival (median, 6.0 months) than non-matched therapy (11% and 1.5 months; p = 0.08 and 0.026; respectively). In patients with squamous cell carcinoma of the cervix, the presence of PIK3CA mutations was associated with a significantly longer overall survival (median, 9.4 months) than the absence of PIK3CA mutations (median, 4.2 months; p = 0.019).ConclusionsMatched therapy targeting the activated PI3K/AKT/mTOR pathway provided meaningful clinical benefits. Thus, further evaluation of PI3K/AKT/mTOR pathway targeted therapy is warranted, especially in metastatic or recurrent squamous cell carcinoma

How Powerful Potential of Attention on Image Restoration?

Transformers have demonstrated their effectiveness in image restoration tasks. Existing Transformer architectures typically comprise two essential components: multi-head self-attention and feed-forward network (FFN). The former captures long-range pixel dependencies, while the latter enables the model to learn complex patterns and relationships in the data. Previous studies have demonstrated that FFNs are key-value memories \cite{geva2020transformer}, which are vital in modern Transformer architectures. In this paper, we conduct an empirical study to explore the potential of attention mechanisms without using FFN and provide novel structures to demonstrate that removing FFN is flexible for image restoration. Specifically, we propose Continuous Scaling Attention (\textbf{CSAttn}), a method that computes attention continuously in three stages without using FFN. To achieve competitive performance, we propose a series of key components within the attention. Our designs provide a closer look at the attention mechanism and reveal that some simple operations can significantly affect the model performance. We apply our \textbf{CSAttn} to several image restoration tasks and show that our model can outperform CNN-based and Transformer-based image restoration approaches

Recombination analysis based on the complete genome of bocavirus

Bocavirus include bovine parvovirus, minute virus of canine, porcine bocavirus, gorilla bocavirus, and Human bocaviruses 1-4 (HBoVs). Although recent reports showed that recombination happened in bocavirus, no systematical study investigated the recombination of bocavirus. The present study performed the phylogenetic and recombination analysis of bocavirus over the complete genomes available in GenBank. Results confirmed that recombination existed among bocavirus, including the likely inter-genotype recombination between HBoV1 and HBoV4, and intra-genotype recombination among HBoV2 variants. Moreover, it is the first report revealing the recombination that occurred between minute viruses of canine

The impact of the Pan-African-aged tectonothermal event on high-grade rocks at Mount Brown, East Antarctica

This study presents monazite and rutile U–Pb and hornblende and biotite 40Ar/39Ar geochronological data for high-grade rocks of the eastern Grenville-aged Rayner orogen at Mount Brown in order to analyse the extent and degree of Pan-African-aged reworking. Monazite from paragneiss yields U–Pb ages of 910 Ma for larger granular grains and 670–630 Ma for smaller globular beads around garnet porphyroblasts or hosted by symplectites. Rutile from leucogneiss yields U–Pb ages of 520–515 Ma. Hornblende and biotite from different rock types yield 40Ar/39Ar plateau ages of 744 and 520–505 Ma, respectively. Combining these results with published zircon U–Pb age data suggests that granulite facies metamorphism occurred at 910 Ma, with a local low-temperature fluid flow event at 670–630 Ma and thermal reworking at 520–505 Ma. The older age of 744 Ma may reflect cooling or partial resetting of the hornblende 40Ar/39Ar system, indicating that Pan-African-aged reworking did not exceed temperatures much higher than the hornblende Ar closure temperature. These data also suggest that the complete isotopic resetting of some minerals may occur without the growth of new mineral phases, providing an example of the style of reworking that is likely to occur in polymetamorphic terranes.This research was supported by the National Natural Science Foundation of China (No. 41530209), Central Public-Interest Scientific Institution Basal Research Fund (No. JYYWF201819) and Geological Investigation Project of the Chinese Geological Survey (No. DD20190579)

Diagnostic value of FNAC combined with BRAFV600E mutation detection in Hashimoto’s thyroiditis complicated with papillary thyroid carcinoma

BackgroundThis study aimed to analyze the effect of preoperative fine needle aspiration cytology (FNAC) combined with BRAFV600E mutation detection as compared to that of fine needle aspiration cytology alone on the diagnostic performance of papillary thyroid carcinoma (PTC) combined with Hashimoto’s thyroiditis (HT).MethodPatients with thyroid nodules in Hashimoto’s thyroiditis, who underwent fine-needle aspiration cytology examination and BRAFV600E mutation detection in the puncture eluate at the outpatient clinic, were selected. Finally, 122 patients received surgical treatment and were included in the study. We used postoperative pathological results as the gold standard. Accordingly, we compared the sensitivity, specificity and accuracy of preoperative FNAC alone and FNAC combined with BRAFV600E mutation detection in for the diagnosis of PTC combined with HT.ResultsFor PTC patients with HT, the sensitivity of FNAC diagnosis was 93.69%, the specificity was 90.90% and the accuracy was 93.44%. However, the sensitivity, specificity and accuracy of FNAC combined with BRAFV600E mutation detection were 97.30%, 90.90% and 96.72%, respectively. Therefore, combined detection can improve the sensitivity and accuracy of diagnosis (p<0.05).ConclusionFNAC combined with eluent BRAFV600E mutation detection can improve the sensitivity and accuracy of diagnosis of PTC in the background of HT