13 research outputs found

    Zero-shot visual reasoning through probabilistic analogical mapping

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    Human reasoning is grounded in an ability to identify highly abstract commonalities governing superficially dissimilar visual inputs. Recent efforts to develop algorithms with this capacity have largely focused on approaches that require extensive direct training on visual reasoning tasks, and yield limited generalization to problems with novel content. In contrast, a long tradition of research in cognitive science has focused on elucidating the computational principles underlying human analogical reasoning; however, this work has generally relied on manually constructed representations. Here we present visiPAM (visual Probabilistic Analogical Mapping), a model of visual reasoning that synthesizes these two approaches. VisiPAM employs learned representations derived directly from naturalistic visual inputs, coupled with a similarity-based mapping operation derived from cognitive theories of human reasoning. We show that without any direct training, visiPAM outperforms a state-of-the-art deep learning model on an analogical mapping task. In addition, visiPAM closely matches the pattern of human performance on a novel task involving mapping of 3D objects across disparate categories

    RIS-based IMT-2030 Testbed for MmWave Multi-stream Ultra-massive MIMO Communications

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    As one enabling technique of the future sixth generation (6G) network, ultra-massive multiple-input-multiple-output (MIMO) can support high-speed data transmissions and cell coverage extension. However, it is hard to realize the ultra-massive MIMO via traditional phased arrays due to unacceptable power consumption. To address this issue, reconfigurable intelligent surface-based (RIS-based) antennas are an energy-efficient enabler of the ultra-massive MIMO, since they are free of energy-hungry phase shifters. In this article, we report the performances of the RIS-enabled ultra-massive MIMO via a project called Verification of MmWave Multi-stream Transmissions Enabled by RIS-based Ultra-massive MIMO for 6G (V4M), which was proposed to promote the evolution towards IMT-2030. In the V4M project, we manufacture RIS-based antennas with 1024 one-bit elements working at 26 GHz, based on which an mmWave dual-stream ultra-massive MIMO prototype is implemented for the first time. To approach practical settings, the Tx and Rx of the prototype are implemented by one commercial new radio base station and one off-the-shelf user equipment, respectively. The measured data rate of the dual-stream prototype approaches the theoretical peak rate. Our contributions to the V4M project are also discussed by presenting technological challenges and corresponding solutions.Comment: 8 pages, 5 figures, to be published in IEEE Wireless Communication

    Engineering zinc oxide hybrid selenium nanoparticles for synergetic anti-tuberculosis treatment by combining Mycobacterium tuberculosis killings and host cell immunological inhibition

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    IntroductionAs a deadly disease induced by Mycobacterium tuberculosis (Mtb), tuberculosis remains one of the top killers among infectious diseases. The low intracellular Mtb killing efficiency of current antibiotics introduced the long duration anti-TB therapy in clinic with strong side effects and increased drug-resistant mutants. Therefore, the exploration of novel anti-TB agents with potent anti-TB efficiency becomes one of the most urgent issues for TB therapies. MethodsHere, we firstly introduced a novel method for the preparation of zinc oxide-selenium nanoparticles (ZnO-Se NPs) by the hybridization of zinc oxide and selenium to combine the anti-TB activities of zinc oxide nanoparticles and selenium nanoparticles. We characterized the ZnO-Se NPs by dynamic laser light scattering and transmission electron microscopy, and then tested the inhibition effects of ZnO-Se NPs on extracellular Mtb by colony-forming units (CFU) counting, bacterial ATP analysis, bacterial membrane potential analysis and scanning electron microscopy imaging. We also analyzed the effects of ZnO-Se NPs on the ROS production, mitochondrial membrane potential, apoptosis, autophagy, polarization and PI3K/Akt/mTOR signaling pathway of Mtb infected THP-1 macrophages. At last, we also tested the effects of ZnO-Se NPs on intracellular Mtb in THP-1 cells by colony-forming units (CFU) counting. ResultsThe obtained spherical core-shell ZnO-Se NPs with average diameters of 90 nm showed strong killing effects against extracellular Mtb, including BCG and the virulent H37Rv, by disrupting the ATP production, increasing the intracellular ROS level and destroying the membrane structures. More importantly, ZnO-Se NPs could also inhibit intracellular Mtb growth by promoting M1 polarization to increase the production of antiseptic nitric oxide and also promote apoptosis and autophagy of Mtb infected macrophages by increasing the intracellular ROS, disrupting mitochondria membrane potential and inhibiting PI3K/Akt/mTOR signaling pathway. DiscussionThese ZnO-Se NPs with synergetic anti-TB efficiency by combining the Mtb killing effects and host cell immunological inhibition effects were expected to serve as novel anti-TB agents for the development of more effective anti-TB strategy
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