8,176 research outputs found

    Power Dynamics: Multiple Equilibria, Cyclical Fluctuations, and Local Stability in Intertemporal General Equilibrium Models

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    Based on the theory of power proposed by John Galbraith, Bertrand Russell and other social scientists, this paper offers two positive intertemporal general equilibrium models to understand: i.) How do rational people decide their optimal consumption, property accumulation, and power? ii.)What causes people to choose different growth path of power? iii.)Why would two people, whose power and wealth endowment levels are quite close, differ so drastically in their future practice? iv.) Why could the rational pursue of power in a "perfect" world is compatible with cyclical power patterns? The simple two-dimensional model considers the dynamic property of power. The second model is an extension of the first model, and analyses the wealth effect on power accumulation. Numerical simulations have provided strong support for our modeling approaches.Power, Stable limit cycles, Hopf bifurcation, Multiple equilibria

    Periodic Modulation Effect on Self-Trapping of Two weakly coupled Bose-Einstein Condensates

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    With phase space analysis approach, we investigate thoroughly the self-trapping phenomenon for two weakly coupled Bose-Einstein condensates (BEC) in a symmetric double-well potential. We identify two kinds of self-trapping by their different relative phase behavior. With applying a periodic modulation on the energy bias of the system we find the occurrence of the self-trapping can be controlled, saying, the transition parameters can be adjusted effectively by the periodic modulation. Analytic expressions for the dependence of the transition parameters on the modulation parameters are derived for high and low frequency modulations. For an intermediate frequency modulation, we find the resonance between the periodic modulation and nonlinear Rabi oscillation dramatically affects the tunnelling dynamics and demonstrate many novel phenomena. Finally, we study the effects of many-body quantum fluctuation on self-trapping and discuss the possible experimental realization of the model.Comment: 7 pages, 11 figure

    Context-Based Customization of Routing Functions for Web GIS Applications

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    This poster presentation features three route planning applications developed by the Florida International University GIS Center and the Geomatics program at the University of Florida, and outlines their context based differences. The first route planner has been developed for cyclists in three Florida counties, i.e. Miami Dade County, Broward County, and Palm Beach County. The second route planner computes safe pedestrian routes to schools and has been developed for Miami Dade County. The third route planner combines pre-compiled cultural/eco routes and point-to-point route planning for the City of Coral Gables. This poster highlights the differences in design (user interface) and implementation (routing options) between the three route planners as a result of a different application context and target audience

    Herpes Simplex Virus Type 2 Immediate Early Protein ICP27 Inhibits IFN-Ī² Production in Mucosal Epithelial Cells by Antagonizing IRF3 Activation.

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    Herpes simplex virus type 2 (HSV-2) is the main cause of genital herpes and infections are common in the lower genital tract. Although neuronal and immune cells can be infected, epithelial cells, and keratinocytes are the primary HSV-2 target cells. HSV-2 establishes latency by evading the host immune system and its infection can also increase the risk of HIV-1 sexual transmission. Our pervious study found that HSV-2 immediate early protein ICP22, inhibited IFN-Ī² production by interfering with the IRF3 pathway. However, ICP22-null HSV-2 did not completely lose the capability of suppressing IFN-Ī² induction, suggesting the involvement of other viral components in the process. In this study, by using an ex vivo cervical explant model, we first demonstrated that HSV-2 can indeed inhibit IFN-Ī² induction in human mucosal tissues. We further identified HSV-2 immediate early protein ICP27 as a potent IFN-Ī² antagonist. ICP27 significantly suppresses the Sendai virus or polyinosinic-polycytidylic acid-induced IFN-Ī² production in human mucosal epithelial cells, showing that ICP27 inhibits the IFN-Ī² promoter activation, and IFN-Ī² production at both mRNA and protein levels. Additional studies revealed that ICP27 directly associates with IRF3 and inhibits its phosphorylation and nuclear translocation, resulting in the inhibition of IFN-Ī² induction. Our findings provide insights into the molecular mechanism underlying HSV-2 mucosal immune evasion, and information for the design of HSV-2 mucosal vaccines
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