A Study on Factors Affecting the Abstention of Drug Abuse in Private Rehabilitation Institutes in Taiwan — Operation Dawn Taiwan as an Example

The purpose of this study is to understand problems of the abstention of drug abuse in Taiwan. Comparing the model of Operation Dawn Taiwan with that of the government’s official rehabilitation institutes, this paper aims to identify advantages and disadvantages of the model in private institutes. The opinions of all inmates and tutors in Operation Dawn Taiwan, the biggest private rehabilitation institute in Taiwan, were collected via questionnaires. This study’s findings show that factors of relapse for a drug abuser after leaving rehabilitation institutes include: 1) the enticement from drug fellows; 2) incapability to resist the allure of drugs; 3) unemployment or hindrances to job-finding; 4) psychological depression; and 5) his/her desire for drugs. Inmates and tutors hold the same opinion on all models of the abstention of drug abuse. Specific suggestions of the abstention of drug abuse in Taiwan will also be discussed in this paper. Finally, inmates consider that career planning has significant positive correlations with abstention

Pseudozyma spp. and Barnettozyma spp. effectively kill cancer cells in vitro

AbstractCancer is the overall leading cause of death in developed countries and also worldwide, and being able to exploit an effective anticancer drug is the aim of all cancer scientists. However, many of the synthetic drugs produced so far usually cause serious side effects, which reduces their therapeutic efficacy. Discovering new drugs or auxiliary therapies derived from natural products might thus provide a novel opportunity for cancer therapy. A recent study reported that some lethal toxins can maintain their activity after being injected into mice. We therefore used two Pseudozyma spp. and three Barnettozyma spp. to examine whether these killer yeasts can preserve their lethal effect on cancer cells under the physical environment (optimum pH, temperature and osmolality, supporting a living cell accomplishes to proliferate, metabolize, differentiate and survive). Our preliminary results showed that both Barnettozyma spp. and Pseudozyma spp. have stronger cytotoxicity against HepG2 than Chang’s liver cells. According to the results of two-dimensional difference gel electrophoresis (2D-DIGE), a total of 115 and 27 proteins differentially expressed by 1.5-fold or more were observed for HepG2 and Chang’s liver cells, respectively. Furthermore, we explored the mechanism involved in the effect of the lethal yeast filtrates on liver cancer cells using 2D-DIGE and mass spectrometry

Earth’s Outgoing Longwave Radiation Variability Prior to M ≥6.0 Earthquakes in the Taiwan Area During 2009–2019

This paper proposes an analysis method, using the National Oceanic and Atmospheric Administration satellite data, to trace variations in outgoing longwave radiation (OLR) for finding the precursors of earthquakes. The significance of these observations is investigated using data sets of recent M ≥6.0 earthquakes around the Taiwan area from 2009 to 2019. We suggest that the precursory signal could be an EIndex anomaly (EA) in the form of substantial thermal releases distributed near the epicenter. The consecutive appearances of OLR EAs are observed as precursors 2–15 days before significant earthquakes, and we refer to this as a pre-earthquake OLR EIndex anomaly (POEA). We interpret these thermal sources as possibly originating from electromagnetics together with gas emissions associated with pre-seismic processes. This study highlights the potential of OLR anomalous changes in earthquake precursor studies, at least in the Taiwan region

Preference-aware content dissemination in opportunistic mobile social networks

Abstract—As mobile devices have become more ubiquitous, mobile users increasingly expect to utilize proximity-based con-nectivity, e.g., WiFi and Bluetooth, to opportunistically share multimedia content based on their personal preferences. However, many previous studies investigate content dissemination protocols that distribute a single object to as many users in an opportunistic mobile social network as possible without considering user preference. In this paper, we propose PrefCast, a preference-aware content dissemination protocol that targets on maximally satisfying user preference for content objects. Due to non-persistent connectivity between users in a mobile social network, when a user meets neighboring users for a limited contact duration, it needs to efficiently disseminate a suitable set of objects that can bring possible future contacts a high utility (the quantitative metric of preference satisfaction). We formulate such a problem as a maximum-utility forwarding model, and propose an algorithm that enables each user to predict how much utility it can contribute to future contacts and solve its optimal forwarding schedule in a distributed manner. Our trace-based evaluation shows that PrefCast can produce a 18.5 % and 25.2 % higher average utility than the protocols that only consider contact frequency or preference of local contacts, respectively. I

A dynamic model of auctions with buy-it-now: theory and evidence

In the ascending-price auctions with Yahoo!-type buy-it-now (BIN), we characterize and derive the closed-form solution for the optimal bidding strategy of the bidder and the optimal BIN price of the seller when they are both risk-averse. The seller is shown to be strictly better o with the BIN option, while the bidders are better o only when their valuation is greater than a threshold value. The theory also implies that the expected transaction price is higher in an auction with an optimal BIN price than one without a BIN. This prediction is conrmed by our data collected from Taiwan's Yahoo! auctions of Nikon digital cameras

A dynamic model of auctions with buy-it-now: theory and evidence

In the ascending-price auctions with Yahoo!-type buy-it-now (BIN), we characterize and derive the closed-form solution for the optimal bidding strategy of the bidder and the optimal BIN price of the seller when they are both risk-averse. The seller is shown to be strictly better o with the BIN option, while the bidders are better o only when their valuation is greater than a threshold value. The theory also implies that the expected transaction price is higher in an auction with an optimal BIN price than one without a BIN. This prediction is conrmed by our data collected from Taiwan's Yahoo! auctions of Nikon digital cameras

Case report: Aortoesophageal fistula—an extremely rare but life-threatening cardiovascular cause of hematemesis

Aortoesophageal fistula (AEF) is an extremely rare cardiovascular etiology of hematemesis and upper gastrointestinal bleeding. As such, its recognition and diagnosis are challenging and may be delayed when such patients present to the emergency department (ED). Without timely surgical intervention, AEF is almost always fatal. Awareness of AEF as a possible diagnosis and consequently early identification of these patients presenting to the ED are therefore crucial in optimizing clinical outcomes. We report a 45-year-old male presenting to the ED with the classical triad of an AEF (Chiari's triad)—midthoracic pain or dysphagia, a sentinel episode of minor hematemesis, then massive hematemesis with risk of exsanguination. The case report highlights the importance of considering the differential diagnosis of AEF when evaluating patients presenting to the ED with hematemesis, especially if they have predisposing risk factors such as prior aortic or esophageal surgeries, aortic aneurysms, or thoracic malignancies. Patients suspected of having AEF should be prioritized for early computed tomography angiography to expedite diagnosis and treatment

Gamma Ray and Radon Anomalies in Northern Taiwan as a Possible Preearthquake Indicator around the Plate Boundary

Taiwan is tectonically situated in an oblique collision zone between the Philippine Sea Plate (PSP) and the Eurasian Plate (EP). Continuous observations of gamma rays at the Yangmingshan (YMSG) station and soil radon at the Tapingti (TPT) station were recorded in the volcanic area and around a major fault zone, respectively, in Taiwan for seismic studies. A number of anomalous high gamma ray counts and radon concentrations at certain times were found. It is noted that significant increases of soil radon concentrations were observed and followed by the increase in gamma rays a few days to a few weeks before earthquakes that occurred in northeastern Taiwan. Earthquakes such as these are usually related to the subduction of the PSP beneath the EP to the north along the subduction zone in northern Taiwan (e.g., ML = 6 4, April 20, 2015). It is suggested that the preseismic activity may be associated with slow geodynamic processes at the subduction interface, leading to the PSP movement triggering radon enhancements at the TPT station. Furthermore, the further movement of the PSP might be blocked by the EP, with the accumulated elastic stress resulting in the increase of gamma rays due to the increase in porosity and fractures below the YMSG station. The continuous monitoring of the multiple parameters can improve the understanding of the relationship between the observed radon and gamma ray variations and the regional crustal stress/strain in north and northeastern Taiwan

Prevalence of intestinal parasitic infections among school children in capital areas of the Democratic Republic of São Tomé and Príncipe, West Africa

Background: Although the Democratic Republic of Sao Tome and Principe (DRSTP) has undertaken school children-based deworming programs against intestinal parasitic infections (IPIs) using a single dose of mebendazole annually since 2005, it remains unclear as to the outcome to date. The present study intends to  investigate the recent IPIs status among school children living in capital areas of the DRSTP.Methods: A total of 252 school children (121 boys and 131 girls) of grades 4 and 5 from 4 primary schools located in the capital areas participated in the present study and their fresh fecal specimens were examined for the presence of any parasites using the merthiolate- iodine-formaldehyde concentration method as conducted.Results: The overall prevalence of IPIs was 64.7% (163/ 252). No significant gender difference in prevalence between boys (67.8%) and girls (61.8%) was found (p = 0.3). The majority of school children were infected with a single species of parasite (55.8%). Altogether, 12 different intestinal parasite species were identified in DRSTP school children, of which 9 species were pathogenic and the remaining 3 were non-pathogenic.Conclusion: Improving the detection method, sanitation facilities and personal hygiene as well as utilizing combined drugs are all important measures to greatly reduce IPIs in DRSTP school children.Keywords: Democratic Republic of Sao Tome and Principe, school children, intestinal parasitic infection

Efficacy of Femarelle for the treatment of climacteric syndrome in postmenopausal women: An open label trial

AbstractObjectiveTo assess the effects of 2 months of treatment with Femarelle for climacteric syndrome in Taiwanese postmenopausal women.Materials and methodsA multi-center, open-label trial of 260 postmenopausal women, age ≥ 45 years with vasomotor symptoms. Women were enrolled after obtaining a detailed medical history and a thorough physical examination. They then received Femarelle (640 mg/d) twice daily for 8 weeks. The primary outcome was the changes in the frequency and severity of hot flushes from baseline to 4 weeks (1 month) and 8 weeks (2 months). Changes of general climacteric syndrome were assessed using a modified climacteric scale designed by Greene.ResultsThe frequency and severity of hot flushes were significantly improved with Femarelle use (p < 0.001). After 8 weeks of treatment, the percentage of women with various climacteric syndromes was reduced (from 100% to 20.9% for hot flushes, from 97.7% to 87.9% for psychological symptoms, from 93.8% to 78.8% for somatic symptoms, and from 87.8% to 74.9% for sexual symptoms). General climacteric syndrome scores also significantly decreased, from 20.8 ± 0.7 at the time of enrollment to 12.9 ± 0.7 after 8 weeks of Femarelle treatment (p < 0.0001). Participants experienced improvement of various climacteric symptoms and signs after 8 weeks of treatment (75.1% for hot flushes, 68.7% for psychological symptoms, 70.6% for somatic symptoms, and 69.0% for sexual problems respectively). After 4 weeks and 8 weeks of treatment with Femarelle, patients showed statistically significant improvement in climacteric symptoms (p < 0.0001). Three women (1.2%) withdrew from the study after 4 weeks of treatment due to adverse effects.ConclusionFemarelle significantly improved climacteric symptoms in Taiwanese postmenopausal women. However, further evaluation is needed regarding the safety of long-term consumption