Vertex reconstruction framework and its implementation for CMS

The class framework developed for vertex reconstruction in CMS is described. We emphasize how we proceed to develop a flexible, efficient and reliable piece of reconstruction software. We describe the decomposition of the algorithms into logical parts, the mathematical toolkit, and the way vertex reconstruction integrates into the CMS reconstruction project ORCA. We discuss the tools that we have developed for algorithm evaluation and optimization and for code release.Comment: Talk from the 2003 Computing in High Energy and Nuclear Physics (CHEP03), La Jolla, Ca, USA, March 2003, 4 pages, LaTeX, no figures. PSN TULT01

Radiolabelling Pt-based quadruplex DNA binders via click chemistry.

Guanine-rich sequences of DNA and RNA can fold into intramolecular tetra-helical assemblies known as G-quadruplexes (G4). Their formation in vivo has been associated to a range of biological functions and therefore they have been identified as potential drug targets. Consequently, a broad range of small molecules have been developed to target G4s. Amongst those are metal complexes with Schiff base ligands. Herein, we report the functionalisation of one of these well-established G4 DNA binders (based on a square planar platinum(II)-salphen complex) with two different radiolabelled complexes. An 111In-conjugate was successfully used to assess its in vivo distribution in a mouse tumour model using single-photon emission computed tomography (SPECT) imaging. These studies highlighted the accumulation of this Pt-salphen-111In conjugate in the tumour

Validation of Kalman Filter alignment algorithm with cosmic-ray data using a CMS silicon strip tracker endcap

A Kalman Filter alignment algorithm has been applied to cosmic-ray data. We discuss the alignment algorithm and an experiment-independent implementation including outlier rejection and treatment of weakly determined parameters. Using this implementation, the algorithm has been applied to data recorded with one CMS silicon tracker endcap. Results are compared to both photogrammetry measurements and data obtained from a dedicated hardware alignment system, and good agreement is observed.Comment: 11 pages, 8 figures. CMS NOTE-2010/00

Radiolabelling of Polyclonally Expanded Human Regulatory T Cells (Treg) with ⁸⁹Zr-oxine for Medium-Term In Vivo Cell Tracking

Regulatory T cells (Tregs) are a promising candidate cell therapy to treat autoimmune diseases and aid the longevity of transplanted solid organs. Despite increasing numbers of clinical trials using human Treg therapy, important questions pertaining to their in vivo fate, distribution, and function remain unanswered. Treg accumulation in relevant tissues was found to be crucial for Treg therapy efficacy, but existing blood-borne biomarkers are unlikely to accurately reflect the tissue state. Non-invasive Treg tracking by whole-body imaging is a promising alternative and can be achieved by direct radiolabelling of Tregs and following the radiolabelled cells with positron emission tomography (PET). Our goal was to evaluate the radiolabelling of polyclonal Tregs with ⁸⁹Zr to permit their in vivo tracking by PET/CT for longer than one week with current preclinical PET instrumentation. We used [⁸⁹Zr]Zr(oxinate)₄ as the cell-labelling agent and achieved successful radiolabelling efficiency of human Tregs spanning 0.1–11.1 Bq ⁸⁹Zr/Treg cell, which would be compatible with PET tracking beyond one week. We characterized the ⁸⁹Zr-Tregs, assessing their phenotypes, and found that they were not tolerating these intracellular ⁸⁹Zr amounts, as they failed to survive or expand in a ⁸⁹Zr-dose-dependent manner. Even at 0.1 Bq ⁸⁹Zr per Treg cell, while ⁸⁹Zr-Tregs remained functional as determined by a five-day-long effector T cell suppression assay, they failed to expand beyond day 3 in vitro. Moreover, PET imaging revealed signs of ⁸⁹Zr-Treg death after adoptive transfer in vivo. In summary, ⁸⁹Zr labelling of Tregs at intracellular radioisotope amounts compatible with cell tracking over several weeks did not achieve the desired outcomes, as ⁸⁹Zr-Tregs failed to expand and survive. Consequently, we conclude that indirect Treg labelling is likely to be the most effective alternative method to satisfy the requirements of this cell tracking scenario

Spatiotemporal in vivo tracking of polyclonal human regulatory T cells reveals a role for innate immune cells in Treg transplant recruitment

Regulatory T cells (Tregs) are emerging as a new cell-based therapy in solid organ transplantation. Adoptive transfer of Tregs was shown preclinically to protect from graft rejection, and the safety of Treg therapy has been demonstrated in clinical trials. Despite these successes, the in vivo distribution and persistence of adoptively transferred Tregs remained elusive which hampers clinical translation. Here, we isolated human Tregs using a GMP-compatible protocol and lentivirally transduced them with the human sodium iodide symporter to render them traceable in vivo by radionuclide imaging. Engineered human Tregs were characterized for phenotype, survival, suppressive capacity, and reporter function. To study their trafficking behaviour, they were subsequently administered to humanized mice with human skin transplants. Traceable Tregs were quantified in skin grafts by non-invasive nanoSPECT/CT for up to 40 days and results validated ex vivo. Using this approach, we demonstrated that Treg trafficking to skin grafts was regulated by the presence of recipient Gr-1⁺ innate immune cells. We demonstrated the utility of radionuclide reporter gene afforded quantitative Treg in vivo tracking thereby addressing a fundamental need in Treg therapy development and offering clinically compatible methodology for future Treg therapy imaging in humans

Probing the Heterogeneity of Protein Kinase Activation in Cells by Super-Resolution Microscopy

Heterogeneity of mitogen-activated protein kinase (MAPK) activation in genetically identical cells, which occurs in response to epidermal growth factor receptor (EGFR) signaling, remains poorly understood. MAPK cascades integrate signals emanating from different EGFR spatial locations, including the plasma membrane and endocytic compartment. We previously hypothesized that in EGF-stimulated cells the MAPK phosphorylation (pMAPK) level and activity are largely determined by the spatial organization of the EGFR clusters within the cell. For experimental testing of this hypothesis, we used super-resolution microscopy to define EGFR clusters by receptor numbers (N) and average intra-cluster distances (d). From this data, we predicted the extent of pMAPK with 85% accuracy on a cell-to-cell basis with control data returning 54% accuracy (P50nm were most predictive for pMAPK level in cells. Electron microscopy revealed that these large clusters were primarily localized to the limiting membrane of multivesicular bodies (MVB). Many tighter packed dimers/multimers (d<50nm) were found on intraluminal vesicles within MVBs, where they were unlikely to activate MAPK because of the physical separation. Our results suggest that cell-to-cell differences in N and d contain crucial information to predict EGFR-activated cellular pMAPK levels and explain pMAPK heterogeneity in isogenic cells

Differential cross section measurements for the production of a W boson in association with jets in proton-proton collisions at root s=7 TeV

Citation: Khachatryan, V., Sirunyan, A. M., Tumasyan, A., Adam, W., Bergauer, T., Dragicevic, M., . . . Collaboration, C. M. S. (2015). Differential cross section measurements for the production of a W boson in association with jets in proton-proton collisions at root s=7 TeV. Physics Letters B, 741, 12-37. doi:10.1016/j.physletb.2014.12.003Measurements are reported of differential cross sections for the production of a W boson, which decays into a muon and a neutrino, in association with jets, as a function of several variables, including the transverse momenta (p(T)) and pseudorapidities of the four leading jets, the scalar sum of jet transverse momenta (H-T), and the difference in azimuthal angle between the directions of each jet and the muon. The data sample of pp collisions at a centre-of-mass energy of 7 TeV was collected with the CMS detector at the LHC and corresponds to an integrated luminosity of 5.0 fb (1). The measured cross sections are compared to predictions from Monte Carlo generators, MADGRAPH + PYTHIA and SHERPA, and to next-to-leading-order calculations from BLACKHAT + SHERPA. The differential cross sections are found to be in agreement with the predictions, apart from the p(T) distributions of the leading jets at high p(T) values, the distributions of the H-T at high-H-T and low jet multiplicity, and the distribution of the difference in azimuthal angle between the leading jet and the muon at low values. (C) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).Additional Authors: Kiesenhofer, W.;Knunz, V.;Krammer, M.;Kratschmer, I.;Liko, D.;Mikulec, I.;Rabady, D.;Rahbaran, B.;Rohringer, H.;Schofbeck, R.;Strauss, J.;Taurok, A.;Treberer-Treberspurg, W.;Waltenberger, W.;Wulz, C. E.;Mossolov, V.;Shumeiko, N.;SuarezGonzalez, J.;Alderweireldt, S.;Bansal, M.;Bansal, S.;Cornelis, T.;De Wolf, E. A.;Janssen, X.;Knutsson, A.;Luyckx, S.;Ochesanu, S.;Roland, B.;Rougny, R.;Van De Klundert, M.;Van Haevermaet, H.;Van Mechelen, P.;Van Remortel, N.;Van Spilbeeck, A.;Blekman, F.;Blyweert, S.;D'Hondt, J.;Daci, N.;Heracleous, N.;Kalogeropoulos, A.;Keaveney, J.;Kim, T. J.;Lowette, S.;Maes, M.;Olbrechts, A.;Python, Q.;Strom, D.;Tavernier, S.;Van Doninck, W.;Van Mulders, P.;Van Onsem, G. P.;Villella, I.;Caillol, C.;Clerbaux, B.;De Lentdecker, G.;Dobur, D.;Favart, L.;Gay, A. P. R.;Grebenyuk, A.;Leonard, A.;Mohammadi, A.;Pernie, L.;Reis, T.;Seva, T.;Thomas, L.;Vander Velde, C.;Vanlaer, P.;Wang, J.;Adler, V.;Beernaert, K.;Benucci, L.;Cimmino, A.;Costantini, S.;Crucy, S.;Dildick, S.;Fagot, A.;Garcia, G.;Klein, B.;McCartin, J.;Rios, A. A. O.;Ryckbosch, D.;Diblen, S. S.;Sigamani, M.;Strobbe, N.;Thyssen, F.;Tytgat, M.;Yazgan, E.;Zaganidis, N.;Basegmez, S.;Beluffi, C.;Bruno, G.;Castello, R.;Caudron, A.;Ceard, L.;Da Silveira, G. G.;Delaere, C.;du Pree, T.;Favart, D.;Forthomme, L.;Giammanco, A.;Hollar, J.;Jez, P.;Komm, M.;Lemaitre, V.;Liao, J.;Nuttens, C.;Pagano, D.;Perrini, L.;Pin, A.;Piotrzkowski, K.;Popov, A.;Quertenmont, L.;Selvaggi, M.;Marono, M. V.;Garcia, J. M. V.;Beliy, N.;Caebergs, T.;Daubie, E.;Hammad, G. H.;Alda, W. L.;Alves, G. A.;Martins, M. C.;Martins, T. D.;Pol, M. E.;Carvalho, W.;Chinellato, J.;Custodio, A.;Da Costa, E. M.;Damiao, D. D.;Martins, C. D.;De Souza, S. F.;Malbouisson, H.;Malek, M.;Figueiredo, D. M.;Mundim, L.;Nogima, H.;Da Silva, W. L. P.;Santaolalla, J.;Santoro, A.;Sznajder, A.;Manganote, E. J. T.;Pereira, A. V.;Bernardes, C. A.;Dias, F. A.;Tomei, Trfp;Gregores, E. M.;Mercadante, P. G.;Novaes, S. F.;Padula, S. S.;Aleksandrov, A.;Genchev, V.;Iaydjiev, P.;Marinov, A.;Piperov, S.;Rodozov, M.;Sultanov, G.;Vutova, M.;Dimitrov, A.;Glushkov, I.;Hadjiiska, R.;Kozhuharov, V.;Litov, L.;Pavlov, B.;Petkov, P.;Bian, J. G.;Chen, G. M.;Chen, H. S.;Chen, M.;Du, R.;Jiang, C. H.;Liang, D.;Liang, S.;Plestina, R.;Tao, J.;Wang, X.;Wang, Z.;Asawatangtrakuldee, C.;Ban, Y.;Guo, Y.;Li, Q.;Li, W.;Liu, S.;Mao, Y.;Qian, S. J.;Wang, D.;Zhang, L.;Zou, W.;Avila, C.;Sierra, L. F. C.;Florez, C.;Gomez, J. P.;Moreno, B. G.;Sanabria, J. C.;Godinovic, N.;Lelas, D.;Polic, D.;Puljak, I.;Antunovic, Z.;Kovac, M.;Brigljevic, V.;Kadija, K.;Luetic, J.;Mekterovic, D.;Sudic, L.;Attikis, A.;Mavromanolakis, G.;Mousa, J.;Nicolaou, C.;Ptochos, F.;Razis, P. A.;Bodlak, M.;Finger, M.;Finger, M.;Assran, Y.;Kamel, A. E.;Mahmoud, M. A.;Radi, A.;Kadastik, M.;Murumaa, M.;Raidal, M.;Tiko, A.;Eerola, P.;Fedi, G.;Voutilainen, M.;Harkonen, J.;Karimaki, V.;Kinnunen, R.;Kortelainen, M. J.;Lampen, T.;Lassila-Perini, K.;Lehti, S.;Linden, T.;Luukka, P.;Maenpaa, T.;Peltola, T.;Tuominen, E.;Tuominiemi, J.;Tuovinen, E.;Wendland, L.;Tuuva, T.;Besancon, M.;Couderc, F.;Dejardin, M.;Denegri, D.;Fabbro, B.;Faure, J. L.;Favaro, C.;Ferri, F.;Ganjour, S.;Givernaud, A.;Gras, P.;de Monchenault, G. H.;Jarry, P.;Locci, E.;Malcles, J.;Rander, J.;Rosowsky, A.;Titov, M.;Baffioni, S.;Beaudette, F.;Busson, P.;Charlot, C.;Dahms, T.;Dalchenko, M.;Dobrzynski, L.;Filipovic, N.;Florent, A.;de Cassagnac, R. G.;Mastrolorenzo, L.;Mine, P.;Mironov, C.;Naranjo, I. N.;Nguyen, M.;Ochando, C.;Paganini, P.;Salerno, R.;Sauvan, J. B.;Sirois, Y.;Veelken, C.;Yilmaz, Y.;Zabi, A.;Agram, J. L.;Andrea, J.;Aubin, A.;Bloch, D.;Brom, J. M.;Chabert, E. C.;Collard, C.;Conte, E.;Fontaine, J. C.;Gele, D.;Goerlach, U.;Goetzmann, C.;Le Bihan, A. C.;Van Hove, P.;Gadrat, S.;Beauceron, S.;Beaupere, N.;Boudoul, G.;Brochet, S.;Montoya, C. A. C.;Chasserat, J.;Chierici, R.;Contardo, D.;Depasse, P.;El Mamouni, H.;Fan, J.;Fay, J.;Gascon, S.;Gouzevitch, M.;Ille, B.;Kurca, T.;Lethuillier, M.;Mirabito, L.;Perries, S.;Alvarez, J. D. R.;Sabes, D.;Sgandurra, L.;Sordini, V.;Donckt, M.;Verdier, P.;Viret, S.;Xiao, H.;Tsamalaidze, Z.;Autermann, C.;Beranek, S.;Bontenackels, M.;Edelhoff, M.;Feld, L.;Hindrichs, O.;Klein, K.;Ostapchuk, A.;Perieanu, A.;Raupach, F.;Sammet, J.;Schael, S.;Sprenger, D.;Weber, H.;Wittmer, B.;Zhukov, V.;Ata, M.;Dietz-Laursonn, E.;Duchardt, D.;Erdmann, M.;Fischer, R.;Guth, A.;Hebbeker, T.;Heidemann, C.;Hoepfner, K.;Klingebiel, D.;Knutzen, S.;Kreuzer, P.;Merschmeyer, M.;Meyer, A.;Olschewski, M.;Padeken, K.;Papacz, P.;Reithler, H.;Schmitz, S. A.;Sonnenschein, L.;Teyssier, D.;Thuer, S.;Weber, M.;Cherepanov, V.;Erdogan, Y.;Flugge, G.;Geenen, H.;Geisler, M.;Ahmad, W. H.;Hoehle, F.;Kargoll, B.;Kress, T.;Kuessel, Y.;Lingemann, J.;Nowack, A.;Nugent, I. M.;Perchalla, L.;Pooth, O.;Stahl, A.;Asin, I.;Bartosik, N.;Behr, J.;Behrenhoff, W.;Behrens, U.;Bell, A. J.;Bergholz, M.;Bethani, A.;Borras, K.;Burgmeier, A.;Cakir, A.;Calligaris, L.;Campbell, A.;Choudhury, S.;Costanza, F.;Pardos, C. D.;Dooling, S.;Dorland, T.;Eckerlin, G.;Eckstein, D.;Eichhorn, T.;Flucke, G.;Garcia, J. G.;Geiser, A.;Gunnellini, P.;Hauk, J.;Hellwig, G.;Hempel, M.;Horton, D.;Jung, H.;Kasemann, M.;Katsas, P.;Kieseler, J.;Kleinwort, C.;Krucker, D.;Lange, W.;Leonard, J.;Lipka, K.;Lobanov, A.;Lohmann, W.;Lutz, B.;Mankel, R.;Marfin, I.;Melzer-Pellmann, I. A.;Meyer, A. B.;Mnich, J.;Mussgiller, A.;Naumann-Emme, S.;Nayak, A.;Novgorodova, O.;Nowak, F.;Ntomari, E.;Perrey, H.;Pitzl, D.;Placakyte, R.;Raspereza, A.;RibeiroCipriano, P. M.;Ron, E.;Sahin, M. O.;Salfeld-Nebgen, J.;Saxena, P.;Schmidt, R.;Schoerner-Sadenius, T.;Schroder, M.;Spannagel, S.;Trevino, Adrv;Walsh, R.;Wissing, C.;Martin, M. A.;Blobel, V.;Vignali, M. C.;Erfle, J.;Garutti, E.;Goebel, K.;Gorner, M.;Gosselink, M.;Haller, J.;Hoffmann, M.;Hoing, R. S.;Kirschenmann, H.;Klanner, R.;Kogler, R.;Lange, J.;Lapsien, T.;Lenz, T.;Marchesini, I.;Ott, J.;Peiffer, T.;Pietsch, N.;Rathjens, D.;Sander, C.;Schettler, H.;Schleper, P.;Schlieckau, E.;Schmidt, A.;Seidel, M.;Sibille, J.;Sola, V.;Stadie, H.;Steinbruck, G.;Troendle, D.;Usai, E.;Vanelderen, L.;Barth, C.;Baus, C.;Berger, J.;Boser, C.;Butz, E.;Chwalek, T.;De Boer, W.;Descroix, A.;Dierlamm, A.;Feindt, M.;Frensch, F.;Giffels, M.;Hartmann, F.;Hauth, T.;Husemann, U.;Katkov, I.;Kornmayer, A.;Kuznetsova, E.;Pardo, P. L.;Mozer, M. U.;Muller, T.;Nurnberg, A.;Quast, G.;Rabbertz, K.;Ratnikov, F.;Rocker, S.;Simonis, H. J.;Stober, F. M.;Ulrich, R.;Wagner-Kuhr, J.;Wayand, S.;Weiler, T.;Wolf, R.;Anagnostou, G.;Daskalakis, G.;Geralis, T.;Giakoumopoulou, V. A.;Kyriakis, A.;Loukas, D.;Markou, A.;Markou, C.;Psallidas, A.;Topsis-Giotis, I.;Panagiotou, A.;Saoulidou, N.;Stiliaris, E.;Aslanoglou, X.;Evangelou, I.;Flouris, G.;Foudas, C.;Kokkas, P.;Manthos, N.;Papadopoulos, I.;Paradas, E.;Bencze, G.;Hajdu, C.;Hidas, P.;Horvath, D.;Sikler, F.;Veszpremi, V.;Vesztergombi, G.;Zsigmond, A. J.;Beni, N.;Czellar, S.;Karancsi, J.;Molnar, J.;Palinkas, J.;Szillasi, Z.;Raics, P.;Trocsanyi, Z. L.;Ujvari, B.;Swain, S. K.;Beri, S. B.;Bhatnagar, V.;Dhingra, N.;Gupta, R.;Kalsi, A. K.;Kaur, M.;Mittal, M.;Nishu, N.;Singh, J. B.;Kumar, A.;Kumar, A.;Ahuja, S.;Bhardwaj, A.;Choudhary, B. C.;Kumar, A.;Malhotra, S.;Naimuddin, M.;Ranjan, K.;Sharma, V.;Banerjee, S.;Bhattacharya, S.;Chatterjee, K.;Dutta, S.;Gomber, B.;Jain, S.;Jain, S.;Khurana, R.;Modak, A.;Mukherjee, S.;Roy, D.;Sarkar, S.;Sharan, M.;Abdulsalam, A.;Dutta, D.;Kailas, S.;Kumar, V.;Mohanty, A. K.;Pant, L. M.;Shukla, P.;Topkar, A.;Aziz, T.;Banerjee, S.;Chatterjee, R. M.;Dewanjee, R. K.;Dugad, S.;Ganguly, S.;Ghosh, S.;Guchait, M.;Gurtu, A.;Kole, G.;Kumar, S.;Maity, M.;Majumder, G.;Mazumdar, K.;Mohanty, G. B.;Parida, B.;Sudhakar, K.;Wickramage, N.;Bakhshiansohi, H.;Behnamian, H.;Etesami, S. M.;Fahim, A.;Goldouzian, R.;Jafari, A.;Khakzad, M.;Najafabadi, M. M.;Naseri, M.;Mehdiabadi, S. P.;Safarzadeh, B.;Zeinali, M.;Felcini, M.;Grunewald, M.;Abbrescia, M.;Barbone, L.;Calabria, C.;Chhibra, S. S.;Colaleo, A.;Creanza, D.;De Filippis, N.;De Palma, M.;Fiore, L.;Iaselli, G.;Maggi, G.;Maggi, M.;My, S.;Nuzzo, S.;Pompili, A.;Pugliese, G.;Radogna, R.;Selvaggi, G.;Silvestris, L.;Singh, G.;Venditti, R.;Verwilligen, P.;Zito, G.;Abbiendi, G.;Benvenuti, A. C.;Bonacorsi, D.;Braibant-Giacomelli, S.;Brigliadori, L.;Campanini, R.;Capiluppi, P.;Castro, A.;Cavallo, F. R.;Codispoti, G.;Cuffiani, M.;Dallavalle, G. M.;Fabbri, F.;Fanfani, A.;Fasanella, D.;Giacomelli, P.;Grandi, C.;Guiducci, L.;Marcellini, S.;Masetti, G.;Montanari, A.;Navarria, F. L.;Perrotta, A.;Primavera, F.;Rossi, A. M.;Rovelli, T.;Siroli, G. P.;Tosi, N.;Travaglini, R.;Albergo, S.;Cappello, G.;Chiorboli, M.;Costa, S.;Giordano, F.;Potenza, R.;Tricomi, A.;Tuve, C.;Barbagli, G.;Ciulli, V.;Civinini, C.;D'Alessandro, R.;Focardi, E.;Gallo, E.;Gonzi, S.;Gori, V.;Lenzi, P.;Meschini, M.;Paoletti, S.;Sguazzoni, G.;Tropiano, A.;Benussi, L.;Bianco, S.;Fabbri, F.;Piccolo, D.;Ferro, F.;Lo Vetere, M.;Robutti, E.;Tosi, S.;Dinardo, M. E.;Fiorendi, S.;Gennai, S.;Gerosa, R.;Ghezzi, A.;Govoni, P.;Lucchini, M. T.;Malvezzi, S.;Manzoni, R. A.;Martelli, A.;Marzocchi, B.;Menasce, D.;Moroni, L.;Paganoni, M.;Pedrini, D.;Ragazzi, S.;Redaelli, N.;de Fatis, T. T.;Buontempo, S.;Cavallo, N.;Di Guida, S.;Fabozzi, F.;Iorio, A. O. M.;Lista, L.;Meola, S.;Merola, M.;Paolucci, P.;Azzi, P.;Bacchetta, N.;Bellato, M.;Bisello, D.;Branca, A.;Carlin, R.;Checchia, P.;Dall'Osso, M.;Dorigo, T.;Galanti, M.;Gasparini, F.;Gasparini, U.;Giubilato, P.;Gozzelino, A.;Kanishchev, K.;Lacaprara, S.;Margoni, M.;Meneguzzo, A. T.;Pazzini, J.;Pozzobon, N.;Ronchese, P.;Sgaravatto, M.;Tosi, M.;Triossi, A.;Ventura, S.;Zucchetta, A.;Zumerle, G.;Ratti, S. P.;Riccardi, C.;Salvini, P.;Vitulo, P.;Biasini, M.;Bilei, G. M.;Ciangottini, D.;Fano, L.;Lariccia, P.;Mantovani, G.;Menichelli, M.;Romeo, F.;Saha, A.;Santocchia, A.;Spiezia, A.;Androsov, K.;Azzurri, P.;Bagliesi, G.;Bernardini, J.;Boccali, T.;Broccolo, G.;Castaldi, R.;Ciocci, M. A.;Dell'Orso, R.;Donato, S.;Fiori, F.;Foa, L.;Giassi, A.;Grippo, M. T.;Ligabue, F.;Lomtadze, T.;Martini, L.;Messineo, A.;Moon, C. S.;Palla, F.;Rizzi, A.;Savoy-Navarro, A.;Serban, A. T.;Spagnolo, P.;Squillacioti, P.;Tenchini, R.;Tonelli, G.;Venturi, A.;Verdini, P. G.;Vernieri, C.;Barone, L.;Cavallari, F.;Del Re, D.;Diemoza, M.;Grassi, M.;Jorda, C.;Longo, E.;Margaroli, F.;Meridiani, P.;Micheli, F.;Nourbakhsh, S.;Organtini, G.;Paramatti, R.;Rahatlou, S.;Rovelli, C.;Santanastasio, F.;Soffi, L.;Traczyk, P.;Amapane, N.;Arcidiacono, R.;Argiro, S.;Arneodo, M.;Bellan, R.;Biino, C.;Cartiglia, N.;Casasso, S.;Costa, M.;Degano, A.;Demaria, N.;Finco, L.;Mariotti, C.;Maselli, S.;Migliore, E.;Monaco, V.;Musich, M.;Obertino, M. M.;Ortona, G.;Pacher, L.;Pastrone, N.;Pelliccioni, M.;Angioni, G. L. P.;Potenza, A.;Romero, A.;Ruspa, M.;Sacchi, R.;Solano, A.;Staiano, A.;Tamponi, U.;Belforte, S.;Candelise, V.;Casarsa, M.;Cossutti, F.;Della Ricca, G.;Gobbo, B.;LaLicata, C.;Marone, M.;Montanino, D.;Schizzi, A.;Umer, T.;Zanetti, A.;Chang, S.;Kropivnitskaya, A.;Nam, S. K.;Kim, D. H.;Kim, G. N.;Kim, M. S.;Kong, D. J.;Lee, S.;Oh, Y. D.;Park, H.;Sakharov, A.;Son, D. C.;Kim, J. Y.;Song, S.;Choi, S.;Gyun, D.;Hong, B.;Jo, M.;Kim, H.;Kim, Y.;Lee, B.;Lee, K. S.;Park, S. K.;Roh, Y.;Choi, M.;Kim, H.;Kim, J. H.;Park, I. C.;Park, S.;Ryu, G.;Ryu, M. S.;Choi, Y.;Choi, Y. K.;Goh, J.;Kwon, E.;Lee, J.;Seo, H.;Yu, I.;Juodagalvis, A.;Komaragiri, J. R.;Castilla-Valdez, H.;De La Cruz-Burelo, E.;Heredia-de La Cruz, I.;Lopez-Fernandez, R.;Sanchez-Hernandez, A.;Moreno, S. C.;Valencia, F. V.;Pedraza, I.;Ibarguen, H. A. S.;Linares, E. C.;Pineda, A. M.;Krofcheck, D.;Butler, P. H.;Reucroft, S.;Ahmad, A.;Ahmad, M.;Hassan, Q.;Hoorani, H. R.;Khalid, S.;Khan, W. A.;Khurshid, T.;Shah, M. A.;Shoaib, M.;Bialkowska, H.;Bluj, M.;Boimska, B.;Frueboes, T.;Gorski, M.;Kazana, M.;Nawrocki, K.;Romanowska-Rybinska, K.;Szleper, M.;Zalewski, P.;Brona, G.;Bunkowski, K.;Cwiok, M.;Dominik, W.;Doroba, K.;Kalinowski, A.;Konecki, M.;Krolikowski, J.;Misiura, M.;Olszewski, M.;Wolszczak, W.;Bargassa, P.;Silva, Cbde;Faccioli, P.;Parracho, P. G. F.;Gallinaro, M.;Nguyen, F.;Antunes, J. R.;Seixas, J.;Varela, J.;Vischia, P.;Golutvin, I.;Karjavin, V.;Konoplyanikov, V.;Korenkov, V.;Kozlov, G.;Lanev, A.;Malakhov, A.;Matveev, V.;Mitsyn, V. V.;Moisenz, P.;Palichik, V.;Perelygin, V.;Shmatov, S.;Shulha, S.;Skatchkov, N.;Smirnov, V.;Tikhonenko, E.;Zarubin, A.;Golovtsov, V.;Ivanov, Y.;Kim, V.;Levchenko, P.;Murzin, V.;Oreshkin, V.;Smirnov, I.;Sulimov, V.;Uvarov, L.;Vavilov, S.;Vorobyev, A.;Vorobyev, A.;Andreev, Y.;Dermenev, A.;Gninenko, S.;Golubev, N.;Kirsanov, M.;Krasnikov, N.;Pashenkov, A.;Tlisov, D.;Toropin, A.;Epshteyn, V.;Gavrilov, V.;Lychkovskaya, N.;Popov, V.;Safronov, G.;Semenov, S.;Spiridonov, A.;Stolin, V.;Vlasov, E.;Zhokin, A.;Andreev, V.;Azarkin, M.;Dremin, I.;Kirakosyan, M.;Leonidov, A.;Mesyats, G.;Rusakov, S. V.;Vinogradov, A.;Belyaev, A.;Boos, E.;Dubinin, M.;Dudko, L.;Ershov, A.;Gribushin, A.;Klyukhin, V.;Kodolova, O.;Lokhtin, I.;Obraztsov, S.;Petrushanko, S.;Savrin, V.;Snigirev, A.;Azhgirey, I.;Bayshev, I.;Bitioukov, S.;Kachanov, V.;Kalinin, A.;Konstantinov, D.;Krychkine, V.;Petrov, V.;Ryutin, R.;Sobol, A.;Tourtchanovitch, L.;Troshin, S.;Tyurin, N.;Uzunian, A.;Volkov, A.;Adzic, P.;Dordevic, M.;Ekmedzic, M.;Milosevic, J.;Maestre, J. A.;Battilana, C.;Calvo, E.;Cerrada, M.;Llatas, M. C.;Colino, N.;De La Cruz, B.;Peris, A. D.;Vazquez, D. D.;Del Valle, A. E.;Bedoya, C. F.;Ramos, J. P. F.;Flix, J.;Fouz, M. C.;Garcia-Abia, P.;Lopez, O. G.;Lopez, S. G.;Hernandez, J. M.;Josa, M. I.;Merino, G.;De Martino, E. N.;Yzquierdo, A. P. C.;Pelayo, J. P.;Olmeda, A. Q.;Redondo, I.;Romero, L.;Soares, M. S.;Albajar, C.;de Troconiz, J. F.;Missiroli, M.;Brun, H.;Cuevas, J.;Menendez, J. F.;Folgueras, S.;Caballero, I. G.;Iglesias, L. L.;Cifuentes, J. A. B.;Cabrillo, I. J.;Calderon, A.;Campderros, J. D.;Fernandez, M.;Gomez, G.;Graziano, A.;Virto, A. L.;Marco, J.;Marco, R.;Rivero, C. M.;Matorras, F.;Sanchez, F. J. M.;Gomez, J. P.;Rodrigo, T.;Rodriguez-Marrero, A. Y.;Ruiz-Jimeno, A.;Scodellaro, L.;Vila, I.;Cortabitarte, R. V.;Abbaneo, D.;Auffray, E.;Auzinger, G.;Bachtis, M.;Baillon, P.;Ball, A. H.;Barney, D.;Benaglia, A.;Bendavid, J.;Benhabib, L.;Benitez, J. F.;Bernet, C.;Bianchi, G.;Bloch, P.;Bocci, A.;Bonato, A.;Bondu, O.;Botta, C.;Breuker, H.;Camporesi, T.;Cerminara, G.;Colafranceschi, S.;D'Alfonso, M.;d'Enterria, D.;Dabrowski, A.;David, A.;De Guio, F.;De Roeck, A.;De Visscher, S.;Dobson, M.;Dupont-Sagorin, N.;Elliott-Peisert, A.;Eugster, J.;Franzoni, G.;Funk, W.;Gigi, D.;Gill, K.;Giordano, D.;Girone, M.;Glege, F.;Guida, R.;Gundacker, S.;Guthoff, M.;Hammer, J.;Hansen, M.;Harris, P.;Hegeman, J.;Innocente, V.;Janot, P.;Kousouris, K.;Krajczar, K.;Lecoq, P.;Lourenco, C.;Magini, N.;Malgeri, L.;Mannelli, M.;Marrouche, J.;Masetti, L.;Meijers, F.;Mersi, S.;Meschi, E.;Moortgat, F.;Morovic, S.;Mulders, M.;Musella, P.;Orsini, L.;Pape, L.;Perez, E.;Perrozzi, L.;Petrilli, A.;Petrucciani, G.;Pfeiffer, A.;Pierini, M.;Pimia, M.;Piparo, D.;Plagge, M.;Racz, A.;Rolandi, G.;Rovere, M.;Sakulin, H.;Schafer, C.;Schwick, C.;Sekmen, S.;Sharma, A.;Siegrist, P.;Silva, P.;Simon, M.;Sphicas, P.;Spiga, D.;Steggemann, J.;Stieger, B.;Stoye, M.;Treille, D.;Tsirou, A.;Veres, G. I.;Vlimant, J. R.;Wardle, N.;Wohri, H. K.;Zeuner, W. D.;Bertl, W.;Deiters, K.;Erdmann, W.;Horisberger, R.;Ingram, Q.;Kaestli, H. C.;Konig, S.;Kotlinski, D.;Langenegger, U.;Renker, D.;Rohe, T.;Bachmair, F.;Bani, L.;Bianchini, L.;Bortignon, P.;Buchmann, M. A.;Casal, B.;Chanon, N.;Deisher, A.;Dissertori, G.;Dittmar, M.;Donega, M.;Dunser, M.;Eller, P.;Grab, C.;Hits, D.;Lustermann, W.;Mangano, B.;Marini, A. C.;del Arbol, P. M. R.;Meister, D.;Mohr, N.;Nageli, C.;Nef, P.;Nessi-Tedaldi, F.;Pandolfi, F.;Pauss, F.;Peruzzi, M.;Quittnat, M.;Rebane, L.;Ronga, F. J.;Rossini, M.;Starodumov, A.;Takahashi, M.;Theofilatos, K.;Wallny, R.;Weber, H. A.;Amsler, C.;Canelli, M. F.;Chiochia, V.;De Cosa, A.;Hinzmann, A.;Hreus, T.;Rikova, M. I.;Kilminster, B.;Mejias, B. M.;Ngadiuba, J.;Robmann, P.;Snoek, H.;Taroni, S.;Verzetti, M.;Yang, Y.;Cardaci, M.;Chen, K. H.;Ferro, C.;Kuo, C. M.;Lin, W.;Lu, Y. J.;Volpe, R.;Yu, S. S.;Chang, P.;Chang, Y. H.;Chang, Y. W.;Chao, Y.;Chen, K. F.;Chen, P. H.;Dietz, C.;Grundler, U.;Hou, W. S.;Kao, K. Y.;Lei, Y. J.;Liu, Y. F.;Lu, R. S.;Majumder, D.;Petrakou, E.;Tzeng, Y. M.;Wilken, R.;Asavapibhop, B.;Srimanobhas, N.;Suwonjandee, N.;Adiguzel, A.;Bakirci, M. N.;Cerci, S.;Dozen, C.;Dumanoglu, I.;Eskut, E.;Girgis, S.;Gokbulut, G.;Gurpinar, E.;Hos, I.;Kangal, E. E.;Topaksu, A. K.;Onengut, G.;Ozdemir, K.;Ozturk, S.;Polatoz, A.;Sogut, K.;Cerci, D. S.;Tali, B.;Topakli, H.;Vergili, M.;Akin, I. V.;Bilin, B.;Bilmis, S.;Gamsizkan, H.;Karapinar, G.;Ocalan, K.;Surat, U. E.;Yalvac, M.;Zeyrek, M.;Gulmez, E.;Isildak, B.;Kaya, M.;Kaya, O.;Bahtiyar, H.;Barlas, E.;Cankocak, K.;Vardarli, F. I.;Yucel, M.;Levchuk, L.;Sorokin, P.;Brooke, J. J.;Clement, E.;Cussans, D.;Flacher, H.;Frazier, R.;Goldstein, J.;Grimes, M.;Heath, G. P.;Heath, H. F.;Jacob, J.;Kreczko, L.;Lucas, C.;Meng, Z.;Newbold, D. M.;Paramesvaran, S.;Poll, A.;Senkin, S.;Smith, V. J.;Williams, T.;Bell, K. W.;Belyaev, A.;Brew, C.;Brown, R. M.;Cockerill, D. J. A.;Coughlan, J. A.;Harder, K.;Harper, S.;Olaiya, E.;Petyt, D.;Shepherd-Themistocleous, C. H.;Thea, A.;Tomalin, I. R.;Womersley, W. J.;Worm, S. D.;Baber, M.;Bainbridge, R.;Buchmuller, O.;Burton, D.;Colling, D.;Cripps, N.;Cutajar, M.;Dauncey, P.;Davies, G.;Della Negra, M.;Dunne, P.;Ferguson, W.;Fulcher, J.;Futyan, D.;Gilbert, A.;Hall, G.;Iles, G.;Jarvis, M.;Karapostoli, G.;Kenzie, M.;Lane, R.;Lucas, R.;Lyons, L.;Magnan, A. M.;Malik, S.;Mathias, B.;Nash, J.;Nikitenko, A.;Pela, J.;Pesaresi, M.;Petridis, K.;Raymond, D. M.;Rogerson, S.;Rose, A.;Seez, C.;Sharp, P.;Tapper, A.;Acosta, M. V.;Virdee, T.;Cole, J. E.;Hobson, P. R.;Khan, A.;Kyberd, P.;Leggat, D.;Leslie, D.;Martin, W.;Reid, I. D.;Symonds, P.;Teodorescu, L.;Turner, M.;Dittmann, J.;Hatakeyama, K.;Kasmi, A.;Liu, H.;Scarborough, T.;Charaf, O.;Cooper, S. I.;Henderson, C.;Rumerio, P.;Avetisyan, A.;Bose, T.;Fantasia, C.;Heister, A.;Lawson, P.;Richardson, C.;Rohlf, J.;Sperka, D.;John, J. S.;Sulak, L.;Alimena, J.;Bhattacharya, S.;Christopher, G.;Cutts, D.;Demiragli, Z.;Ferapontov, A.;Garabedian, A.;Heintz, U.;Jabeen, S.;Kukartsev, G.;Laird, E.;Landsberg, G.;Luk, M.;Narain, M.;Segala, M.;Sinthuprasith, T.;Speer, T.;Swanson, J.;Breedon, R.;Breto, G.;Sanchez, M. C. D.;Chauhan, S.;Chertok, M.;Conway, J.;Conway, R.;Cox, P. T.;Erbacher, R.;Gardner, M.;Ko, W.;Lander, R.;Miceli, T.;Mulhearn, M.;Pellett, D.;Pilot, J.;Ricci-Tam, F.;Searle, M.;Shalhout, S.;Smith, J.;Squires, M.;Stolp, D.;Tripathi, M.;Wilbur, S.;Yohay, R.;Cousins, R.;Everaerts, P.;Farrell, C.;Hauser, J.;Ignatenko, M.;Rakness, G.;Takasugi, E.;Valuev, V.;Weber, M.;Babb, J.;Clare, R.;Ellison, J.;Gary, J. W.;Hanson, G.;Heilman, J.;Jandir, P.;Kennedy, E.;Lacroix, F.;Liu, H.;Long, O. R.;Luthra, A.;Malberti, M.;Nguyen, H.;Shrinivas, A.;Sumowidagdo, S.;Wimpenny, S.;Andrews, W.;Branson, J. G.;Cerati, G. B.;Cittolin, S.;D'Agnolo, R. T.;Evans, D.;Holzner, A.;Kelley, R.;Klein, D.;Lebourgeois, M.;Letts, J.;Macneill, I.;Olivito, D.;Padhi, S.;Palmer, C.;Pieri, M.;Sani, M.;Sharma, V.;Simon, S.;Sudano, E.;Tadel, M.;Tu, Y.;Vartak, A.;Welke, C.;Wuerthwein, F.;Yagil, A.;Yoo, J.;Barge, D.;Bradmiller-Feld, J.;Campagnari, C.;Danielson, T.;Dishaw, A.;Flowers, K.;Sevilla, M. F.;Geffert, P.;George, C.;Golf, F.;Gouskos, L.;Incandela, J.;Justus, C.;McColl, N.;Richman, J.;Stuart, D.;To, W.;West, C.;Apresyan, A.;Bornheim, A.;Bunn, J.;Chen, Y.;Di Marco, E.;Duarte, J.;Mott, A.;Newman, H. B.;Pena, C.;Rogan, C.;Spiropulu, M.;Timciuc, V.;Wilkinson, R.;Xie, S.;Zhu, R. Y.;Azzolini, V.;Calamba, A.;Ferguson, T.;Iiyama, Y.;Paulini, M.;Russ, J.;Vogel, H.;Vorobiev, I.;Cumalat, J. P.;Drell, B. R.;Ford, W. T.;Gaz, A.;Lopez, E. L.;Nauenberg, U.;Smith, J. G.;Stenson, K.;Ulmer, K. A.;Wagner, S. R.;Alexander, J.;Chatterjee, A.;Chu, J.;Dittmer, S.;Eggert, N.;Hopkins, W.;Mirman, N.;Kaufman, G. N.;Patterson, J. R.;Ryd, A.;Salvati, E.;Skinnari, L.;Sun, W.;Teo, W. D.;Thom, J.;Thompson, J.;Tucker, J.;Weng, Y.;Winstrom, L.;Wittich, P.;Winn, D.;Abdullin, S.;Albrow, M.;Anderson, J.;Apollinari, G.;Bauerdick, L. A. T.;Beretvas, A.;Berryhill, J.;Bhat, P. C.;Burkett, K.;Butler, J. N.;Cheung, H. W. K.;Chlebana, F.;Cihangir, S.;Elvira, V. D.;Fisk, I.;Freeman, J.;Gao, Y.;Gottschalk, E.;Gray, L.;Green, D.;