Single-cell RNA-sequencing reveals Transcriptional Changes and Clonal Architecture associated with Post-Transplant Relapse in Acute Myeloid Leukemia

"Acute myeloid leukemia (AML) is a malignancy characterized by overproduction of myeloid precursors at the expense of more differentiated, functional hematopoietic cells, resulting in anemia, thrombocytopenia, and neutropenia. Despite initial sensitivity to chemotherapy, a majority of patients with AML ultimately relapse. Among the challenges associated with relapse, post-allogeneic stem cell transplant relapse is particularly intractable because of our relative lack of understanding - and thus lack of effective treatment options - of the underlying mechanisms."--IntroductionZiheng Xu (1), Christopher A. Miller (2, 3), Sridhar N. Srivatsan (2), Catrina C. Fronick (3), Robert S. Fulton (3), Timothy J. Ley (2, 3, 4), and Allegra A. Petti (2, 3) ; 1. Washington University School of Medicine. 2. Division of Oncology, Washington University School of Medicine. 3. McDonnell Genome Institute, Washington University School of Medicine. 4. Department of Genetics, Washington University School of Medicine.Includes bibliographical reference

Sequence analysis in Bos taurus reveals pervasiveness of X–Y arms races in mammalian lineages

Studies of Y Chromosome evolution have focused primarily on gene decay, a consequence of suppression of crossing-over with the X Chromosome. Here, we provide evidence that suppression of X-Y crossing-over unleashed a second dynamic: selfish X-Y arms races that reshaped the sex chromosomes in mammals as different as cattle, mice, and men. Using super-resolution sequencing, we explore the Y Chromosome o