The Pediatric Cell Atlas: defining the growth phase of human development at single-cell resolution

Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan

Письменная речь на уроке иностранного языка. Виды упражнений на развитие навыков письменной речи

The paper gives valuable information about the writing as an aspect of oral activity. Authors analyze reasons why teachers of foreign languages have no interest to the writing. Similarity between writing and listening, speaking, reading is emphasized and it’s positive impact on the process of memorizing.Much attention is given tosome methodical recommendations andsome practical advice on aspects of writing in German language in linguistic university.Статья привлекает внимание к такому виду речевой деятельности, как письмо. Авторы анализируют причины отсутствия интереса педагогов к формированию навыка письма. Подчеркивается взаимосвязь между аудированием, говорением, чтением и письмом, а также его положительное влияние на процессзапоминания.В статье даются методические рекомендации и практические советы по обучению письму на немецком языке на начальном этапе в лингвистическом вузе

Словообразование в современном немецком языке в контексте обучения лексике

This paper gives valuable information about word-formation in modern German in the Context of Learning Vocabulary. Authors analyze techniques for the formation of new words, examine numerous examples, point out the most productive methods of word-formation. Much attention is given to English-American borrowings in German.Статья привлекает внимание к приемам словообразования в современном немецком языке при обучении лексике. Авторы анализируют приемы образования новых слов, приводя многочисленные примеры, и выделяют наиболее продуктивные способы словообразования. Большое внимание уделяется англо- американским заимствованиям в немецком языке

ZEMSTVO OF THE XIX-XX CENTURIES. IN RUSSIA: THE FORMATION OF SOCIAL INFRASTRUCTURE AT THE LOCAL LEVEL

The article analyzes the role of the Zemstvo reform carried out in Russia in the XIX-early XX centuries for the development and management of social infrastructure at the local level. The research methods were a retrospective analysis and a comparative method. The authors identified trends in the financial and economic support of the Zemstvo bodies at various stages of the Zemstvo reform, investigated the advantages and disadvantages of the Zemstvo reform. The analysis of the main indicators of the development of social infrastructure in the second half of the XIX – early XX century was carried out on the basis of the statistical method. As a result of the study, the authors conclude that the success of the Zemstvo was determined by the close interaction of the government and the population, support for local initiatives, and the formation of a system of public control

Supply Chain Infrastructure Development in Russian Economy

The article is devoted to the study of the activities of Zemstvo institutions for the development of supply chain infrastructure in the XIX-early XX centuries; identification of the role of the Zemstvo reform in the formation of supply chain infrastructure at the local level. Supply Chain infrastructure provides the means for chain economic entities and firms sharing a common interest to participate in a mutual exchange. Despite the fact that the provision of supply chain services was not among the priorities of the Zemstvos, significant results were achieved. The retrospective analysis allowed us to highlight the advantages and disadvantages of the Zemstvo self-government system. The comparative method helped to identify trends in the financial and economic support of Zemstvo bodies at various stages of the Zemstvo reform, and to analyze key indicators of supply chain infrastructure development. It is concluded that the success of the Zemstvo self-government bodies in the development of supply chain infrastructure was due to the availability of significant organizational resources, ensuring sustainable interaction of Zemstvos with the population, active support for local initiatives and the formation of a system of public control. The authors note that the experience of implementing the principle of consolidation of the main directions of management activities for the development of supply chain infrastructure, formed by local authorities, can be in demand in modern conditions and adapted to the current system of local government in Russia for economy efficiency

Pension Security in Russia: Major Problems and Assessments of the Population

The authors consider stereotypes, expectations and attitude of Russian citizens to the formation and management of pension savings, studied the resources and limitations that determine the responsible attitude to financial security in old age. In the course of the research, a mass questionnaire survey of the population. As the results of the research have shown, Russians are rather pessimistic about the prospects of their aging. Lack of appropriate economic models of behavior, both in personal and parental experience, and low level of trust in power and the pension system form negative expectations and devaluate real efforts in the population's mind to ensure a decent old age