Sequential stereopsis using high-pass spatial frequency filtered textures

Enright [(1995). Perception, 24 (suppl.), 32–33; (1996). Vision Research, 36, 307–312] described a simple piece of equipment for demonstrating a perceptual mechanism he called sequential stereopsis. The equipment requires an observer to set two textured targets seen behind a pair of small viewing ports to appear equi-distant. The principle upon which the apparatus depends is the use of textures whose elements cannot be resolved in peripheral vision at the eccentricity determined by the target separation. Enright used a fine sandpaper for this purpose. We have conducted two similar experiments using high bandpass filtered textures which eliminate any possibility that the low spatial frequency content of sandpaper textures could play a role. Our results corroborate Enright's general conclusions on sequential stereopsis, while at the same time showing that high-pass textures do not give wholly similar results to sandpaper

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

SummaryBackground Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatoryactions. We aimed to evaluate the safety and efficacy of azithromycin in patients admitted to hospital with COVID-19.Methods In this randomised, controlled, open-label, adaptive platform trial (Randomised Evaluation of COVID-19Therapy [RECOVERY]), several possible treatments were compared with usual care in patients admitted to hospitalwith COVID-19 in the UK. The trial is underway at 176 hospitals in the UK. Eligible and consenting patients wererandomly allocated to either usual standard of care alone or usual standard of care plus azithromycin 500 mg once perday by mouth or intravenously for 10 days or until discharge (or allocation to one of the other RECOVERY treatmentgroups). Patients were assigned via web-based simple (unstratified) randomisation with allocation concealment andwere twice as likely to be randomly assigned to usual care than to any of the active treatment groups. Participants andlocal study staff were not masked to the allocated treatment, but all others involved in the trial were masked to theoutcome data during the trial. The primary outcome was 28-day all-cause mortality, assessed in the intention-to-treatpopulation. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936.Findings Between April 7 and Nov 27, 2020, of 16 442 patients enrolled in the RECOVERY trial, 9433 (57%) wereeligible and 7763 were included in the assessment of azithromycin. The mean age of these study participants was65·3 years (SD 15·7) and approximately a third were women (2944 [38%] of 7763). 2582 patients were randomlyallocated to receive azithromycin and 5181 patients were randomly allocated to usual care alone. Overall,561 (22%) patients allocated to azithromycin and 1162 (22%) patients allocated to usual care died within 28 days(rate ratio 0·97, 95% CI 0·87–1·07; p=0·50). No significant difference was seen in duration of hospital stay (median10 days [IQR 5 to >28] vs 11 days [5 to >28]) or the proportion of patients discharged from hospital alive within 28 days(rate ratio 1·04, 95% CI 0·98–1·10; p=0·19). Among those not on invasive mechanical ventilation at baseline, nosignificant difference was seen in the proportion meeting the composite endpoint of invasive mechanical ventilationor death (risk ratio 0·95, 95% CI 0·87–1·03; p=0·24).Interpretation In patients admitted to hospital with COVID-19, azithromycin did not improve survival or otherprespecified clinical outcomes. Azithromycin use in patients admitted to hospital with COVID-19 should be restrictedto patients in whom there is a clear antimicrobial indication

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Uncalibrated Relief Reconstruction and Model Alignment from Binocular Disparities

We propose a computational scheme for uncalibrated reconstruction of scene structure up to a relief transformation from binocular disparities. This scheme, which we call regional disparity correction (RDC), is motivated both by computational considerations and by psychophysical observations regarding human stereoscopic depth perception. We describe an implementation of RDC, and demonstrate its performance experimentally. As an example of applications of RDC, we show how it can be used to align a three-dimensional object model with an uncalibrated disparity field. Keywords: stereo, disparity, uncalibrated reconstruction, relief transformation, human vision, model alignment 1 Introduction Binocular disparities, i.e., the slightly different views captured by two eyes or cameras, can convey important information about the three-dimensional structure of the scene. In machine vision, the classical approach is to combine disparities with precise camera calibration information in order to r..

Plant endemism in Griqualand West, South Africa

Griqualand West, a region in the semi-arid Northern Cape and North-West provinces of South Africa, has been variously suggested to contain a number of range-restricted plant species, and was proposed to be a local centre of plant endemism. The Griqualand West Centre (GWC), hitherto demarcated by geological features and limited floristic data, is hereby investigated to determine the true levels of endemism and its extent of occurrence. Findings suggest that at least 23 plant species have their natural distribution ranges restricted to the Griqualand West region. These endemics represent 1.4% of the region's flora. Although this is a lower than the predicted level of endemism, it matches the trends of endemicity found in other centres in semi-arid savanna of southern Africa. Many of the GWC endemics show indications of holo-endemism owing to their apparent preference for the Ca- and Mg-rich substrates of the Ghaap Plateau. When the total distributions of all GWC endemic species are considered, then the resulting boundary of the GWC is more extensive than the substantial area already proposed previously (> 40,000 km2). This study therefore proposes the concept of ‘core area’ in which distant outlier populations of endemic species (> 100 km outside the main distribution range with no suitable habitat in between) are discarded during the demarcation of the centre's boundary. It is proposed that this concept is best applied when assessing extensive areas with few endemic species. A more refined GWC core area will allow for more effective conservation and future research efforts by focussing attention on those areas where high numbers of endemic plant species co-occur. Within the GWC core area, specific regions, such as the increasingly densely populated Kimberley region, the banded ironstone hill ranges, and the unique environment that is the Ghaap Plateau, are highlighted as areas of conservation importance.The National Research Foundation (Grant UID: 103370), South Africahttp://www.elsevier.com/locate/sajb2020-08-01hj2020Plant Production and Soil Scienc

Pooling of vertical disparities by the human visual system

Two experiments are described in which the effects of scaling vertical disparities on the perceived amplitudes of dome-shaped surfaces depicted with horizontal disparities were examined. The Mayhew and Longuet-Higgins's theory and the regional-disparity-correction theory of Garding et al predict that scaling should generate a change in perceived depth appropriate to the viewing distance simulated by the scaled vertical disparities. Significant depth changes were observed, by means of a nulling task in which the vertical-disparity-scaling effect was cancelled by the observer choosing a pattern of horizontal disparities that made the dome-shaped surface appear flat. The sizes of the scaling effects were less than those predicted by either theory, suggesting that other cues to fixation distance such as oculomotor information played an appreciable role. In conditions in which 50% of the texture elements were given one value of vertical-disparity scaling and the remaining 50% were left unscaled, the size of the scaling effect on perceived depth could be accounted for by equally weighted pooling of the vertical-disparity information unless the two scalings were very dissimilar, in which case the lower scaling factor tended to dominate. These findings are discussed in terms of a Hough parameter estimation model of the vertical-disparity-pooling process