3 research outputs found
Erregerspektrum, Resistenzmuster und kalkulierte Initialtherapie bei bakteriellen Infektionen am Albert-Schweitzer-Hospital in Lambaréné
Steigende Antibiotikaresistenzen stellen ressourcenarme und tropische Länder vor Herausforderungen. Um für Lambaréné in Gabun (Zentralafrika) eine evidenzbasierte Grundlage zur Antibiotikatherapie zu schaffen, wurden retrospektiv mikrobiologische Befunde von 2009 bis 2012 von Blutstrom-, Haut-, Weichgewebe-, Harnwegs-, Ohr- und Wundinfektionen am Albert-Schweitzer-Krankenhaus analysiert. Das Erregerspektrum war meist heterogen. Jedoch war in mit Haut- und Weichgewebe assoziierten Infektionen der häufigste Erreger Staphylococcus aureus. Hierunter waren 4 % (n = 13) methicillinresistent. Der Anteil von ESBL-produzierenden Stämmen an allen isolierten Enterobacteriaceae war 13 % (n = 87). Die höchste ESBL-Rate war unter Isolaten der Blutkulturen (27 %, n = 39). Die hohe Diversität an Pathogenen und die hohen Resistenzraten insbesondere bei gramnegativen Bakterien erschweren die kalkulierte Antibiotikatherapie. Eine kontinuierliche landesweite ist Überwachung dringend notwendig
Retrospective analysis of antimicrobial resistance and bacterial spectrum of infection in Gabon, Central Africa
Background: Physicians depend on reliable information on the local epidemiology of infection and antibiotic resistance rates to guide empiric treatment in critically ill patients. As these data are scarce for Central Africa, we performed a retrospective analysis of microbiological findings from a secondary care hospital in Gabon. Methods: Microbiological reports from 2009 to 2012 were used to assess the non-susceptibility rates of the three most common isolates from six major types of infections (bloodstream, ear-eye-nose-throat, surgical site, skin and soft tissue, urinary tract and wound infection). Results: A high diversity of pathogens was found, but Staphylococcus aureus was predominant in the majority of infections. Overall, the three most prevalent pathogens in children were S. aureus (33.7%), Streptococcus pyogenes (8.1%) and Escherichia coli (4.5%) and in adults S. aureus (23.5%), E. coli (15.1%) and Klebsiella pneumoniae (7.4%). In total, 5.8% (n = 19) of all S. aureus isolates were methicillin resistant. The proportion of extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae was 15.4% (n = 78), 49.4% of all K. pneumoniae were ESBL-producer (n = 42). Conclusion: The high diversity of potential pathogens and high resistance rates in Gram-negative bacteria challenge a rational empiric use of antibiotics. Countrywide continuous sentinel surveillance is therefore urgently needed.<br
The risk to import ESBL-producing Enterobacteriaceae and Staphylococcus aureus through chicken meat trade in Gabon
Background: A main export market for chicken meat from industrialized countries is sub-Saharan Africa. We hypothesized that antibiotic resistant bacteria could be exported to developing countries through chicken meat trade. The objective was to investigate the occurrence and molecular types of ESBL-producing Enterobacteriaceae and Staphylococcus aureus in chicken meat in Gabon and to assess their dissemination among humans. Results: Frozen chicken meat samples imported from industrialized countries to Gabon (n = 151) were screened for ESBL-producing Enterobacteriaceae and S. aureus. Genotypes and resistance genes (SHV, TEM, CTX-M, CMY-2) of isolates from meat were compared with isolates derived from humans. The contamination rate per chicken part (i. e. leg, wing) with ESBL-producing Escherichia coli (ESBL E. coli, no other ESBL-producing Enterobacteriaceae were found) and S. aureus was 23% and 3%, respectively. The beta-lactamase CTX-M 1 was predominant in ESBL E. coli from meat samples but was not found in isolates from cases of human colonization or infection. S. aureus belonging to spa type t002 (multilocus sequence type ST5) were found both in chicken meat and humans. Conclusion: There is a risk to import ESBL E. coli to Gabon but molecular differences between isolates from humans and chicken meat argue against a further dissemination. No MRSA isolate was detected in imported chicken meat.<br