Nitric Oxide-Releasing Nanoparticles Prevent Propionibacterium acnes-Induced Inflammation by Both Clearing the Organism and Inhibiting Microbial Stimulation of the Innate Immune Response.

Propionibacterium acnes induction of IL-1 cytokines through the NLRP3 (NLR, nucleotide oligomerization domain-like receptor) inflammasome was recently highlighted as a dominant etiological factor for acne vulgaris. Therefore, therapeutics targeting both the stimulus and the cascade would be ideal. Nitric oxide (NO), a potent biological messenger, has documented broad-spectrum antimicrobial and immunomodulatory properties. To harness these characteristics to target acne, we used an established nanotechnology capable of generating/releasing NO over time (NO-np). P. acnes was found to be highly sensitive to all concentrations of NO-np tested, although human keratinocyte, monocyte, and embryonic zebra fish assays revealed no cytotoxicity. NO-np significantly suppressed IL-1β, tumor necrosis factor-α (TNF-α), IL-8, and IL-6 from human monocytes, and IL-8 and IL-6 from human keratinocytes, respectively. Importantly, silencing of NLRP3 expression by small interfering RNA did not limit NO-np inhibition of IL-1 β secretion from monocytes, and neither TNF-α nor IL-6 secretion, nor inhibition by NO-np was found to be dependent on this pathway. The observed mechanism by which NO-np impacts IL-1β secretion was through inhibition of caspase-1 and IL-1β gene expression. Together, these data suggest that NO-np can effectively prevent P. acnes-induced inflammation by both clearing the organism and inhibiting microbial stimulation of the innate immune response

Possible Room Temperature Ferromagnetism in Hydrogenated Carbon Nanotubes

We find that ferromagnetism can be induced in carbon nanotubes (CNTs) by introducing hydrogen. Multiwalled CNTs grown inside porous alumina templates contain a large density of defects resulting in significant hydrogen uptake when annealed at high temperatures. This hydrogen incorporation produces H-complex and adatom magnetism which generates a sizeable ferromagnetic moment and a Curie temperature near Tc=1000 K. We studied the conditions for the incorporation of hydrogen, the temperature-dependent magnetic behavior, and the dependence of the ferromagnetism on the size of the nanotubes.Comment: 15 pages with 3 figures included; Accepted by Phys. Rev.

CfAIR2: Near Infrared Light Curves of 94 Type Ia Supernovae

CfAIR2 is a large homogeneously reduced set of near-infrared (NIR) light curves for Type Ia supernovae (SN Ia) obtained with the 1.3m Peters Automated InfraRed Imaging TELescope (PAIRITEL). This data set includes 4607 measurements of 94 SN Ia and 4 additional SN Iax observed from 2005-2011 at the Fred Lawrence Whipple Observatory on Mount Hopkins, Arizona. CfAIR2 includes JHKs photometric measurements for 88 normal and 6 spectroscopically peculiar SN Ia in the nearby universe, with a median redshift of z~0.021 for the normal SN Ia. CfAIR2 data span the range from -13 days to +127 days from B-band maximum. More than half of the light curves begin before the time of maximum and the coverage typically contains ~13-18 epochs of observation, depending on the filter. We present extensive tests that verify the fidelity of the CfAIR2 data pipeline, including comparison to the excellent data of the Carnegie Supernova Project. CfAIR2 contributes to a firm local anchor for supernova cosmology studies in the NIR. Because SN Ia are more nearly standard candles in the NIR and are less vulnerable to the vexing problems of extinction by dust, CfAIR2 will help the supernova cosmology community develop more precise and accurate extragalactic distance probes to improve our knowledge of cosmological parameters, including dark energy and its potential time variation.Comment: 31 pages, 15 figures, 10 tables. Accepted to ApJS. v2 modified to more closely match journal versio

High-speed metamagnetic resistive switching of FeRh through Joule heating

Due to its proximity to room temperature and demonstrated high degree of temperature tunability, the metamagnetic ordering transition in FeRh is attractive for novel high-performance computing devices seeking to use magnetism as the state variable. We demonstrate electrical control of the transition via Joule heating in FeRh wires. Finite element simulations based on abrupt state transition within each domain result in a globally smooth transition that agrees with the experimental findings and provides insight into the thermodynamics involved. We measure a 150 K decrease in transition temperature with currents up to 60 mA, limited only by the dimensions of the device. The sizeable shift in transition temperature scales with current density and wire length, suggesting the absolute resistance and heat dissipation of the substrate are also important. The FeRh phase change is evaluated by pulsed I-V using a variety of bias conditions. We demonstrate high speed (~ ns) memristor-like behavior and report device performance parameters such as switching speed and power consumption that compare favorably with state-of-the-art phase change memristive technologies.Comment: 35 pages, 9 figure

Singular perturbation techniques in the gravitational self-force problem

Much of the progress in the gravitational self-force problem has involved the use of singular perturbation techniques. Yet the formalism underlying these techniques is not widely known. I remedy this situation by explicating the foundations and geometrical structure of singular perturbation theory in general relativity. Within that context, I sketch precise formulations of the methods used in the self-force problem: dual expansions (including matched asymptotic expansions), for which I identify precise matching conditions, one of which is a weak condition arising only when multiple coordinate systems are used; multiscale expansions, for which I provide a covariant formulation; and a self-consistent expansion with a fixed worldline, for which I provide a precise statement of the exact problem and its approximation. I then present a detailed analysis of matched asymptotic expansions as they have been utilized in calculating the self-force. Typically, the method has relied on a weak matching condition, which I show cannot determine a unique equation of motion. I formulate a refined condition that is sufficient to determine such an equation. However, I conclude that the method yields significantly weaker results than do alternative methods.Comment: 39 pages, 5 figures, final version to be published in Phys. Rev. D, several typos corrected, added discussion of order-reductio

Constraints on Brane Inflation and Cosmic Strings

By considering simple, but representative, models of brane inflation from a single brane-antibrane pair in the slow roll regime, we provide constraints on the parameters of the theory imposed by measurements of the CMB anisotropies by WMAP including a cosmic string component. We find that inclusion of the string component is critical in constraining parameters. In the most general model studied, which includes an inflaton mass term, as well as the brane-antibrane attraction, values n_s < 1.02 are compatible with the data at 95 % confidence level. We are also able to constrain the volume of internal manifold (modulo factors dependent on the warp factor) and the value of the inflaton field to be less than 0.66M_P at horizon exit. We also investigate models with a mass term. These observational considerations suggest that such models have r < 2*10^-5, which can only be circumvented in the fast roll regime, or by increasing the number of antibranes. Such a value of r would not be detectable in CMB polarization experiment likely in the near future, but the B-mode signal from the cosmic strings could be detectable. We present forecasts of what a similar analysis using PLANCK data would yield and find that it should be possible to rule out G\mu > 6.5*10^-8 using just the TT, TE and EE power spectra.Comment: 11 pages, 3 figures, revtex4, typos corrected, references adde