32 research outputs found

    Nominally significant SNPs from the longitudinal models in the GLACIER Study (N = 3,495 for ΔTC; N = 2,211 for ΔTG).

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    <p>95% CI–95% confidence interval; β - beta coefficient; ΔTC - total cholesterol change; ΔTG - triglyceride change; EA - effect allele; EAF - effect allele frequency; FDR - false discovery rate; SE - standard error; SNP - single nucleotide polymorphism</p><p><i>P</i> values are based on linear regression models. SNP associations were tested by fitting the previously associated individual variants (additive model) as the independent variables with lipid trait changes as dependent variables. We adjusted the raw <i>P</i> values for multiple-testing using Benjamini-Hochberg's FDR.</p

    Longitudinal characteristics of the MDC Study participants (N = 2,943).

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    <p>BMI - body mass index; HDL-C - high density lipoprotein cholesterol; IQR - interquartile range; LDL-C - low density lipoprotein cholesterol; SD - standard deviation; TC - total cholesterol; TG - triglyceride.</p><p>*Only median is reported for TG, as the trait's distribution is not Gaussian.</p

    Pairwise differences between ROC AUC curves and classification statistics in relation to hyperlipidemia in GLACIER (N = 1,257 for TC; N = 1,660 for TG).

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    <p>NPV - negative predictive value; PPV - positive predictive value; ROC AUC - receiver operating characteristics area under the curve; TC - total cholesterol; TG - triglyceride.</p><p><i>P</i> values are calculated by a chi squared test comparing two ROC AUC curves.</p><p>Model 1  =  age,age<sup>2</sup>;sex,BMI; Model 2 =  Model 1+ trait specific GRS; Model 3 =  Model 1+ traditional risk factors (cholesterol intake, trans fat intake, saturated fat intake, carbohydrate intake, alcohol intake, physical activity); Model 4 =  Model 1+ trait specific GRS + traditional risk factors.</p
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