Time outdoors and the prevention of myopia

Recent epidemiological evidence suggests that children who spend more time outdoors are less likely to be, or to become myopic, irrespective of how much near work they do, or whether their parents are myopic. It is currently uncertain if time outdoors also blocks progression of myopia. It has been suggested that the mechanism of the protective effect of time outdoors involves light-stimulated release of dopamine from the retina, since increased dopamine release appears to inhibit increased axial elongation, which is the structural basis of myopia. This hypothesis has been supported by animal experiments which have replicated the protective effects of bright light against the development of myopia under laboratory conditions, and have shown that the effect is, at least in part, mediated by dopamine, since the D2-dopamine antagonist spiperone reduces the protective effect. There are some inconsistencies in the evidence, most notably the limited inhibition by bright light under laboratory conditions of lens-induced myopia in monkeys, but other proposed mechanisms possibly associated with time outdoors such as relaxed accommodation, more uniform dioptric space, increased pupil constriction, exposure to UV light, changes in the spectral composition of visible light, or increased physical activity have little epidemiological or experimental support. Irrespective of the mechanisms involved, clinical trials are now underway to reduce the development of myopia in children by increasing the amount of time they spend outdoors. These trials would benefit from more precise definition of thresholds for protection in terms of intensity and duration of light exposures. These can be investigated in animal experiments in appropriate models, and can also be determined in epidemiological studies, although more precise measurement of exposures than those currently provided by questionnaires is desirable

A procedure to analyze nonlinear density waves in Saturn's rings using several occultation profiles

Cassini radio science experiments have provided multiple occultation optical depth profiles of Saturn's rings that can be used in combination to analyze density waves. This paper establishes an accurate procedure of inversion of the wave profiles to reconstruct the wave kinematic parameters as a function of semi-major axis, in the nonlinear regime. This procedure is achieved from simulated data in the presence of realistic noise perturbations, to control the reconstruction error. By way of illustration we have applied our procedure to the Mimas 5:3 density wave. We were able to recover precisely the kinematic parameters from the radio experiment occultation data in most of the propagation region; a preliminary analysis of the pressure-corrected dispersion allowed us to determine new but still uncertain values for the opacity ($K\simeq 0.02$ cm$^2$/g) and velocity dispersion of ($c_o\simeq 0.6$ cm/s) in the wave region. Our procedure constitutes the first step in our planned analysis of the density waves of Saturn's rings. It is very accurate and efficient in the far-wave region. However, improvements are required within the first wavelength. The ways in which this method can be used to establish diagnostics of ring physics are outlined.Comment: 50 pages,13 figures, 2 tables. Published in Icarus

An overall strategy based on regression models to estimate relative survival and model the effects of prognostic factors in cancer survival studies.

Relative survival provides a measure of the proportion of patients dying from the disease under study without requiring the knowledge of the cause of death. We propose an overall strategy based on regression models to estimate the relative survival and model the effects of potential prognostic factors. The baseline hazard was modelled until 10 years follow-up using parametric continuous functions. Six models including cubic regression splines were considered and the Akaike Information Criterion was used to select the final model. This approach yielded smooth and reliable estimates of mortality hazard and allowed us to deal with sparse data taking into account all the available information. Splines were also used to model simultaneously non-linear effects of continuous covariates and time-dependent hazard ratios. This led to a graphical representation of the hazard ratio that can be useful for clinical interpretation. Estimates of these models were obtained by likelihood maximization. We showed that these estimates could be also obtained using standard algorithms for Poisson regression

Violation of the isotropic-ℓ\ell approximation in overdoped La_{2-x}Sr_xCuO_4

Magnetotransport measurements on the overdoped cuprate La_{1.7}Sr_{0.3}CuO_4 are fitted using the Ong construction and band parameters inferred from angle-resolved photoemission. Within a band picture, the low temperature Hall data can only be fitted satisfactorily by invoking strong basal-plane anisotropy in the mean-free-path $\ell$. This violation of the isotropic-$\ell$ approximation supports a picture of dominant small-angle elastic scattering in cuprates due to out-of-plane substitutional disorder. We show that both band anisotropy and anisotropy in the elastic scattering channel strongly renormalize the Hall coefficient in overdoped La_{2-x}Sr_xCuO_4 over a wide doping and temperature range.Comment: 4 pages, 4 figure

Cofactor regeneration by a soluble pyridine nucleotide transhydrogenase for biological production of hydromorphone

We have applied the soluble pyridine nucleotide transhydrogenase of Pseudomonas fluorescens to a cell-free system for the regeneration of the nicotinamide cofactors NAD and NADP in the biological production of the important semisynthetic opiate drug hydromorphone. The original recombinant whole-cell system suffered from cofactor depletion resulting from the action of an NADP(+)-dependent morphine dehydrogenase and an NADH-dependent morphinone reductase. By applying a soluble pyridine nucleotide transhydrogenase, which can transfer reducing equivalents between NAD and NADP, we demonstrate with a cell-free system that efficient cofactor cycling in the presence of catalytic amounts of cofactors occurs, resulting in high yields of hydromorphone. The ratio of morphine dehydrogenase, morphinone reductase, and soluble pyridine nucleotide transhydrogenase is critical for diminishing the production of the unwanted by-product dihydromorphine and for optimum hydromorphone yields. Application of the soluble pyridine nucleotide transhydrogenase to the whole-cell system resulted in an improved biocatalyst with an extended lifetime. These results demonstrate the usefulness of the soluble pyridine nucleotide transhydrogenase and its wider application as a tool in metabolic engineering and biocatalysis

Hydrogen Dissociation and Diffusion on Ni and Ti -doped Mg(0001) Surfaces

It is well known, both theoretically and experimentally, that alloying MgH$_2$ with transition elements can significantly improve the thermodynamic and kinetic properties for H$_2$ desorption, as well as the H$_2$ intake by Mg bulk. Here we present a density functional theory investigation of hydrogen dissociation and surface diffusion over Ni-doped surface, and compare the findings to previously investigated Ti-doped Mg(0001) and pure Mg(0001) surfaces. Our results show that the energy barrier for hydrogen dissociation on the pure Mg(0001) surface is high, while it is small/null when Ni/Ti are added to the surface as dopants. We find that the binding energy of the two H atoms near the dissociation site is high on Ti, effectively impeding diffusion away from the Ti site. By contrast, we find that on Ni the energy barrier for diffusion is much reduced. Therefore, although both Ti and Ni promote H$_2$ dissociation, only Ni appears to be a good catalyst for Mg hydrogenation, allowing diffusion away from the catalytic sites. Experimental results corroborate these theoretical findings, i.e. faster hydrogenation of the Ni doped Mg sample as opposed to the reference Mg or Ti doped Mg.Comment: 17 pages, 15 figures, to appear in Journal of Chemical Physic

The motion of two masses coupled to a massive spring

We discuss the classical motion of a spring of arbitrary mass coupled to two arbitrary massive blocks attached at its ends. A general approach to the problem is presented and some general results are obtained. Examples for which a simple elastic function can be inferred are discussed and the normal modes and normal frequencies obtained. An approximation procedure to the evaluation of the normel frequencies in the case of uniform elastic function and mass density is also discussed.Comment: Standard Latex file plus three eps figure

Correlation between TcT_c and anisotropic scattering in Tl2_2Ba2_2CuO6+δ_{6+\delta}

Angle-dependent magnetoresistance measurements are used to determine the isotropic and anisotropic components of the transport scattering rate in overdoped Tl$_2$Ba$_2$CuO$_{6+\delta}$ for a range of $T_c$ values between 15K and 35K. The size of the anisotropic scattering term is found to scale linearly with $T_c$, establishing a link between the superconducting and normal state physics. Comparison with results from angle resolved photoemission spectroscopy indicates that the transport and quasiparticle lifetimes are distinct.Comment: 5 pages, 3 figures, accepted for publication in Physical Review Letter

Predictors of vigorous exercise adoption and maintenance over four years in a community sample

BACKGROUND: Very little is known about the correlates of adoption and maintenance of vigorous exercise. The purpose of this study was to understand the sociodemographic correlates of exercise adoption and maintenance in a community sample. METHODS: 917 women and 229 men completed annual surveys as part of a community-based weight gain prevention trial over four years. Multivariate regressions evaluated predictive factors for maintenance of vigorous exercise over time in regular exercisers, and predictors of adoption of exercise in adults who were sedentary at baseline. RESULTS: Exercise maintenance at Years 2 and 3 was associated with ethnicity and exercise level at baseline, while exercise maintenance at Year 4 was associated with television watching, BMI and exercise at baseline. Exercise level at baseline was associated with exercise initiation at Year 2 and Year 3. Income level, marital status, and smoking status predicted exercise initiation at Year 4. CONCLUSIONS: Predictors of vigorous exercise maintenance were more consistent than predictors of vigorous exercise initiation. Results suggest that those who adopt vigorous exercise are a heterogeneous group and intervention messages could be more broadly focused. These data also suggest that exercise maintenance interventions should continue to target low-income populations with messages regarding smoking, weight and television. Clearly further research is needed to understand the factors that contribute to exercise initiation and maintenance, and to develop effective interventions to improve levels of physical activity levels