9,133 research outputs found
Crystallization and preliminary diffraction studies of morphinone reductase, a flavoprotein involved in the degradation of morphine alkaloids
U(3) and Pseudo-U(3) Symmetry of the Relativistic Harmonic Oscillator
We show that a Dirac Hamiltonian with equal scalar and vector harmonic
oscillator potentials has not only a spin symmetry but an U(3) symmetry and
that a Dirac Hamiltonian with scalar and vector harmonic oscillator potentials
equal in magnitude but opposite in sign has not only a pseudospin symmetry but
a pseudo-U(3) symmetry. We derive the generators of the symmetry for each case.Comment: 8 pages, 0 figures, pusblished in Physical Review Letters 95, 252501
(2005
A procedure to analyze nonlinear density waves in Saturn's rings using several occultation profiles
Cassini radio science experiments have provided multiple occultation optical
depth profiles of Saturn's rings that can be used in combination to analyze
density waves. This paper establishes an accurate procedure of inversion of the
wave profiles to reconstruct the wave kinematic parameters as a function of
semi-major axis, in the nonlinear regime. This procedure is achieved from
simulated data in the presence of realistic noise perturbations, to control the
reconstruction error. By way of illustration we have applied our procedure to
the Mimas 5:3 density wave. We were able to recover precisely the kinematic
parameters from the radio experiment occultation data in most of the
propagation region; a preliminary analysis of the pressure-corrected dispersion
allowed us to determine new but still uncertain values for the opacity
( cm/g) and velocity dispersion of ( cm/s) in
the wave region. Our procedure constitutes the first step in our planned
analysis of the density waves of Saturn's rings. It is very accurate and
efficient in the far-wave region. However, improvements are required within the
first wavelength. The ways in which this method can be used to establish
diagnostics of ring physics are outlined.Comment: 50 pages,13 figures, 2 tables. Published in Icarus
Human immunodeficiency virus (HIV) in developing countries.
The human immunodeficiency virus (HIV) is causing the most destructive epidemic of recent times, having been responsible for the deaths of more than 25 million people since it was first recognised in 1981. This global epidemic remains out of control, with reported figures for 2005 of 40 million people infected with HIV. During 2005 there were 4.9 million new infections, showing that transmission is not being prevented, and there were 3.1 million deaths from the acquired immunodeficiency syndrome (AIDS), reflecting the lack of a definitive cure and the limited access to suppressive antiretroviral treatment in the developing countries that are most severely affected. The current state of the epidemic and the response to date are here reviewed. Present and future opportunities for prevention, treatment and surveillance are discussed, with particular reference to progress towards an HIV vaccine, the expansion of the provision of highly active antiretroviral therapy, and the need to focus control programmes on HIV as an infectious disease, rather than as a development issue
Correlation between and anisotropic scattering in TlBaCuO
Angle-dependent magnetoresistance measurements are used to determine the
isotropic and anisotropic components of the transport scattering rate in
overdoped TlBaCuO for a range of values between 15K
and 35K. The size of the anisotropic scattering term is found to scale linearly
with , establishing a link between the superconducting and normal state
physics. Comparison with results from angle resolved photoemission spectroscopy
indicates that the transport and quasiparticle lifetimes are distinct.Comment: 5 pages, 3 figures, accepted for publication in Physical Review
Letter
Probing the interiors of the ice giants: Shock compression of water to 700 GPa and 3.8 g/ccm
Recently there has been tremendous increase in the number of identified
extra-solar planetary systems. Our understanding of their formation is tied to
exoplanet internal structure models, which rely upon equations of state of
light elements and compounds like water. Here we present shock compression data
for water with unprecedented accuracy that shows water equations of state
commonly used in planetary modeling significantly overestimate the
compressibility at conditions relevant to planetary interiors. Furthermore, we
show its behavior at these conditions, including reflectivity and isentropic
response, is well described by a recent first-principles based equation of
state. These findings advocate this water model be used as the standard for
modeling Neptune, Uranus, and "hot Neptune" exoplanets, and should improve our
understanding of these types of planets.Comment: Accepted to Phys. Rev. Lett.; supplementary material attached
including 2 figures and 2 tables; to view attachments, please download and
extract the gzipped tar source file listed under "Other formats
Crystallization and preliminary diffraction studies of pentaerythritol tetranitrate reductase from Enterobacter cloacae PB2
Artificial Brains and Hybrid Minds
The paper develops two related thought experiments exploring variations on an ‘animat’ theme. Animats are hybrid devices with both artificial and biological components. Traditionally, ‘components’ have been construed in concrete terms, as physical parts or constituent material structures. Many fascinating issues arise within this context of hybrid physical organization. However, within the context of functional/computational theories of mentality, demarcations based purely on material structure are unduly narrow. It is abstract functional structure which does the key work in characterizing the respective ‘components’ of thinking systems, while the ‘stuff’ of material implementation is of secondary importance. Thus the paper extends the received animat paradigm, and investigates some intriguing consequences of expanding the conception of bio-machine hybrids to include abstract functional and semantic structure. In particular, the thought experiments consider cases of mind-machine merger where there is no physical Brain-Machine Interface: indeed, the material human body and brain have been removed from the picture altogether. The first experiment illustrates some intrinsic theoretical difficulties in attempting to replicate the human mind in an alternative material medium, while the second reveals some deep conceptual problems in attempting to create a form of truly Artificial General Intelligence
Genomic variations define divergence of water/wildlife-associated Campylobacter jejuni niche specialists from common clonal complexes
Although the major food-borne pathogen Campylobacter jejuni has been isolated from diverse animal, human and environmental sources, our knowledge of genomic diversity in C. jejuni is based exclusively on human or human food-chain-associated isolates. Studies employing multilocus sequence typing have indicated that some clonal complexes are more commonly associated with particular sources. Using comparative genomic hybridization on a collection of 80 isolates representing diverse sources and clonal complexes, we identified a separate clade comprising a group of water/wildlife isolates of C. jejuni with multilocus sequence types uncharacteristic of human food-chain-associated isolates. By genome sequencing one representative of this diverse group (C. jejuni 1336), and a representative of the bank-vole niche specialist ST-3704 (C. jejuni 414), we identified deletions of genomic regions normally carried by human food-chain-associated C. jejuni. Several of the deleted regions included genes implicated in chicken colonization or in virulence. Novel genomic insertions contributing to the accessory genomes of strains 1336 and 414 were identified. Comparative analysis using PCR assays indicated that novel regions were common but not ubiquitous among the water/wildlife group of isolates, indicating further genomic diversity among this group, whereas all ST-3704 isolates carried the same novel accessory regions. While strain 1336 was able to colonize chicks, strain 414 was not, suggesting that regions specifically absent from the genome of strain 414 may play an important role in this common route of Campylobacter infection of humans. We suggest that the genomic divergence observed constitutes evidence of adaptation leading to niche specialization
Visualising apoptosis in live zebrafish using fluorescence lifetime imaging with optical projection tomography to map FRET biosensor activity in space and time
Fluorescence lifetime imaging (FLIM) combined with optical projection tomography (OPT) has the potential to map Förster resonant energy transfer (FRET) readouts in space and time in intact transparent or near transparent live organisms such as zebrafish larvae, thereby providing a means to visualise cell signalling processes in their physiological context. Here the first application of FLIM OPT to read out biological function in live transgenic zebrafish larvae using a genetically expressed FRET biosensor is reported. Apoptosis, or programmed cell death, is mapped in 3-D by imaging the activity of a FRET biosensor that is cleaved by Caspase 3, which is a key effector of apoptosis. Although apoptosis is a naturally occurring process during development, it can also be triggered in a variety of ways, including through gamma irradiation. FLIM OPT is shown here to enable apoptosis to be monitored over time, in live zebrafish larvae via changes in Caspase 3 activation following gamma irradiation at 24 hours post fertilisation. Significant apoptosis was observed at 3.5 hours post irradiation, predominantly in the head region
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