143 research outputs found
Energy Consumption, Trade Openness and Exchange Rate Impact on Foreign Direct Investment in Union State of Russia and Belarus
In this paper we investigate the casual relationship between energy consumption, trade openness, exchange rate and foreign direct investment in Union State of Russia and Belarus for the period from 1997 to 2017. To test the hypothesis and explain the possible casual relations we use the error correction approach. Result of the conducted research show that in the short run trade openness and exchange rate affect foreign direct investment in positive and significant manner. In the long run, energy consumption, trade openness and exchange rate positively affect foreign direct investment.
Keywords: Foreign direct investment, energy consumption, trade openness, exchange rate, error correction model
JEL Classifications: F21, F31, Q4
What is the effect of alcohol consumption on the risk of chronic widespread pain? : A Mendelian randomisation study using UK Biobank
This research has been conducted using the UK Biobank resource, application no. 1144, and was funded by the University of Aberdeen. MF is funded by the EU FP7 project PainOmics (contract #602736). The authors have no conflicts of interest to declarePeer reviewedPostprin
Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss
Hearing loss is one of the top contributors to years lived with disability and is a risk factor for dementia. Molecular evidence on the cellular origins of hearing loss in humans is growing. Here, we performed a genome-wide association meta-analysis of clinically diagnosed and self reported hearing impairment on 723,266 individuals and identified 48 significant loci, 10 of which are novel. A large proportion of associations comprised missense variants, half of which lie within known familial hearing loss loci. We used single-cell RNA-sequencing data from mouse cochlea and brain and mapped common-variant genomic results to spindle, root, and basal cells from the stria vascularis, a structure in the cochlea necessary for normal hearing. Our findings indicate the importance of the stria vascularis in the mechanism of hearing impairment, providing future paths for developing targets for therapeutic intervention in hearing loss.Peer reviewe
Vertebral Endplate Defect as Initiating Factor in Intervertebral Disc Degeneration; Strong Association between Endplate Defect and Disc Degeneration in the General Population
Association of Polymorphisms in the Human IL4 and IL5 Genes With Atopic Bronchial Asthma and Severity of the Disease
Two polymorphisms in the IL4 (G/C 3′-UTR) and IL5 (C-703T) genes were studied in a sample of families whose probands had atopic bronchial asthma (BA) (66 families,
n = 183) and in a group of non-cognate individuals with the severe form of the disease
(n = 34). The samples were collected from the Russian population in the city of Tomsk
(Russia). Using the transmission/disequilibrium test (TDT), a significant association
of allele C-703 IL5 with BA was established (TDT = 4.923, p = 0.007 ± 0.0007). The
analysis of 40 individuals with mild asthma and 49 patients with the severe form
of the disease revealed a negative association of genotype GG IL4 (OR = 0.39, 95%
CI = 0.15−0.99, p = 0.035), and also a trend towards a positive association of the
GC IL4 genotype (OR = 2.52, 95% CI = 0.98−6.57, p = 0.052) with mild BA. There
was a concordance of the clinical classification of BA severity with the ‘genotype’
(McNemar’s χ2 test with continuity correction constituted 0.03, d.f. = 1, p = 0.859).
These results suggest that polymorphisms in the IL4 and IL5 genes contribute to the
susceptibility to atopic BA and could determine the clinical course of the disease
Genes of the Glutamatergic System and Tardive Dyskinesia in Patients with Schizophrenia
Background: Tardive dyskinesia (TD) is an extrapyramidal side effect of the long-term use of antipsychotics. In the present study, the role of glutamatergic system genes in the pathogenesis of total TD, as well as two phenotypic forms, orofacial TD and limb-truncal TD, was studied. Methods: A set of 46 SNPs of the glutamatergic system genes (GRIN2A, GRIN2B, GRIK4, GRM3, GRM7, GRM8, SLC1A2, SLC1A3, SLC17A7) was studied in a population of 704 Caucasian patients with schizophrenia. Genotyping was performed using the MassARRAY Analyzer 4 (Agena Bioscience™). Logistic regression analysis was performed to test for the association of TD with the SNPs while adjusting for confounders. Results: No statistically significant associations between the SNPs and TD were found after adjusting for multiple testing. Since three SNPs of the SLC1A2 gene demonstrated nominally significant associations, we carried out a haplotype analysis for these SNPs. This analysis identified a risk haplotype for TD comprising CAT alleles of the SLC1A2 gene SNPs rs1042113, rs10768121, and rs12361171. Nominally significant associations were identified for SLC1A3 rs2229894 and orofacial TD, as well as for GRIN2A rs7192557 and limb-truncal TD. Conclusions: Genes encoding for mGlu3, EAAT2, and EAAT1 may be involved in the development of TD in schizophrenia patients
Hyperprolactinemia and CYP2D6, DRD2 and HTR2C genes polymorphism in patients with schizophrenia
Hyperprolactinemia and CYP2D6, DRD2 and HTR2C genes polymorphism in patients with schizophrenia
Dissimilar mechanistic background of peripheral and orofacial hyperkinesia in patients with Parkinson’s disease and levodopa-induced dyskinesia
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