Matrimonial Sweets

1Do cease your clack and hold your tongue,You\u27re always teazing, squalling, bawling,You\u27re always quarreling all day longAnd ugly names are calling;You know you ne\u27er can be at peace,Now pray, do let your passion cease,You\u27re never quiet, O, I deny it,Madam, you\u27ll my rage increase,O dear, O dear, \u27tis the plague of my life That ever I became your wife, O dear, O dear, \u27tis the plague of my life That ever I became your wife. 2You know you\u27re always gadding about,Dancing, walking, chatting talking,You know from morn till nightYou\u27re out with other ladies walkingYou know you\u27re always after fellows\u27Tis only you\u27re so very jealous,You\u27ll own you do it,O, you shall rue it,We\u27re a happy pair, so people tell us, O dear, O dear, \u27tis the plague of my life That ever you became my wife, O dear, O dear, \u27tis the plague of my life That ever you became my wife.3You\u27ll own your temper\u27s very bad,Looks so flouting, always pouting. Your\u27s is enough to drive one mad,Suspicious, jealous, doubting.You know my passion don\u27t remain,But soon as off begins again,O, how vexing, how perplexingYou\u27ll put me in a rage again. O dear, O dear, \u27tis the plague of my life That ever you became my wife, O dear, O dear, \u27tis the plague of my life That ever you became my wife. 4Madam, we had better part,Than by living constant din in.O\u27 I\u27ll agree with all my heart,Let\u27s be the task beginning.I hereby bid a last adieu,And I now take a final view,North, South, East, West,Take which corner you like best. O dear, O dear, I now for lifeAm rid of my tormenting wife,O dear, O dear, I now for lifeForsake the office of a wife. Well then, Madam, as your are determined to go, goodbyeGoodbye sir. You\u27ll recollect, Madam, \u27tis all your ownfault. I beg your pardon, sir, \u27tis all your own fault. I say \u27tis your\u27s sir. Zounds, Madam, I say \u27tis your. Youknow I never was in a passion. 5My dearest, love, don\u27t leave me so.Without measure, you\u27re my pleasure.You know, my love, I could not go,For you\u27re my darling treasure.Then for the future let\u27s agree,And live in sweetest harmony,Nor let to-morrowBring forth sorrowTo crush our sweet felicity.O dear, O dear, \u27tis the joy of lifeThat ever I became your wife,O dear, O dear, \u27tis the joy of my lifeThat ever you became my wife

Matrimonial Sweets

Do cease your clack and hold your tongueYou\u27re always teazing squalling bawling You\u27re always quarrelling all day long And ugly names are calling You know you ne\u27er can be at peace Now pray do let your passion ceaseYou\u27re never quiet I deny it Madam you\u27ll my rage increase Oh dear Oh dear tis the plague of my lifeThat ever I became your wifeOh dear Oh dear tis the plague of my lifeThat ever you became my wife.Oh dear Oh dear \u27tis the plague of my lifeThat ever you became my wife. You know you\u27re always gadding aboutDancing, Walking, Chatting, TalkingYou know from morn \u27till bight you\u27re outWith other ladies walkingYou know you\u27re always after fellows\u27Tis only you\u27re so very jealousYou\u27ll own you do itOh you shall rue itWe\u27re a happy pair of people tell usOh dear oh dear &c. You\u27ll own you tempers very badLooks so flouting always poutingYours is enough to drive one madSuspicious, jealous, doubtingYou know my passion dont remain But soon as off begins againOh how vexingHow perplexingYou\u27ll put me in a rage againOh dear oh dear &c. My dearest love don\u27t leave me soWithout measure you\u27re my pleasure You know my love I could not go For you\u27re my darling treasureThen for the future let\u27s agreeAnd live in sweetest harmonyNor let to morrowMadam we had better partThan by living constant din inOh i\u27ll agree with all my heart Let\u27s be the task beginningI hereby bid a last adieuAnd bow I take a final viewNorthsouthEastWestTake which corner you like bestOh dear oh dear i now for lifeAm rid of my tormenting wife Oh dear oh dear I now for lifeForsake the office of a wifeWell then Madam as you are determined to go good bye good bye sirYou\u27ll recollect madam\u27tis all your own faultI beg you pardon sir\u27tis all your own faultI say\u27tis yours sirZounds madam I say\u27tis yoursYou know I was in a passion. Bring forth sorrowTo crush our sweet felicityOh dear oh dear \u27tis the joy of my lifeThat I ever became your wifeOh dear oh dear \u27tis the joy of my lifeThat ever you became my wif

On the Interplay between the Evolvability and Network Robustness in an Evolutionary Biological Network: A Systems Biology Approach

In the evolutionary process, the random transmission and mutation of genes provide biological diversities for natural selection. In order to preserve functional phenotypes between generations, gene networks need to evolve robustly under the influence of random perturbations. Therefore, the robustness of the phenotype, in the evolutionary process, exerts a selection force on gene networks to keep network functions. However, gene networks need to adjust, by variations in genetic content, to generate phenotypes for new challenges in the network’s evolution, ie, the evolvability. Hence, there should be some interplay between the evolvability and network robustness in evolutionary gene networks. In this study, the interplay between the evolvability and network robustness of a gene network and a biochemical network is discussed from a nonlinear stochastic system point of view. It was found that if the genetic robustness plus environmental robustness is less than the network robustness, the phenotype of the biological network is robust in evolution. The tradeoff between the genetic robustness and environmental robustness in evolution is discussed from the stochastic stability robustness and sensitivity of the nonlinear stochastic biological network, which may be relevant to the statistical tradeoff between bias and variance, the so-called bias/variance dilemma. Further, the tradeoff could be considered as an antagonistic pleiotropic action of a gene network and discussed from the systems biology perspective

The dimensions of software engineering success

Software engineering research and practice are hampered by the lack of a well-understood, top-level dependent variable. Recent initiatives on General Theory of Software Engineering suggest a multifaceted variable – Software Engineering Success. However, its exact dimensions are unknown. This paper investigates the dimensions (not causes) of software engineering success. An interdisciplinary sample of 191 design professionals (68 in the software industry) were interviewed concerning their perceptions of success. Non-software designers (e.g. architects) were included to increase the breadth of ideas and facilitate comparative analysis. Transcripts were subjected to supervised, semi-automated semantic content analysis, including a software developer vs. other professionals comparison. Findings suggest that participants view their work as time-constrained projects with explicit clients and other stakeholders. Success depends on stakeholder impacts – financial, social, physical and emotional – and is understood through feedback. Concern with meeting explicit requirements is peculiar to software engineering and design is not equated with aesthetics in many other fields. Software engineering success is a complex multifaceted variable, which cannot sufficiently be explained by traditional dimensions including user satisfaction, profitability or meeting requirements, budgets and schedules. A proto-theory of success is proposed, which models success as the net impact on a particular stakeholder at a particular time. Stakeholder impacts are driven by project efficiency, artifact quality and market performance. Success is not additive, e.g., ‘low’ success for clients does not average with ‘high’ success for developers to make ‘moderate’ success overall; rather, a project may be simultaneously successful and unsuccessful from different perspectives

Science lives: School choices and ‘natural tendencies’

An analysis of 12 semi-structured interviews with university-based scientists and non-scientists illustrates their life journeys towards, or away from, science and the strengths and impact of life occurrences leading them to choose science or non-science professions. We have adopted narrative approaches and used Mezirow's transformative learning theory framework. The areas of discussion from the result have stressed on three main categories that include ‘smooth transition’, ‘incremental wavering transition' and ‘transformative transition’. The article concludes by discussing the key influences that shaped initial attitudes and direction in these people through natural inclination, environmental inspirations and perceptions of science

Loss of intra-islet heparan sulfate is a highly sensitive marker of type 1 diabetes progression in humans

Type 1 diabetes (T1D) is an autoimmune disease in which insulin-producing beta cells in pancreatic islets are progressively destroyed. Clinical trials of immunotherapies in recently diagnosed T1D patients have only transiently and partially impacted the disease course, suggesting that other approaches are required. Our previous studies have demonstratedthat heparan sulfate (HS), a glycosaminoglycan conventionally expressed in extracellular matrix, is present at high levels inside normal mouse beta cells. Intracellular HS was shownto be critical for beta cell survival and protection from oxidative damage. T1D development in Non-Obese Diabetic (NOD) mice correlated with loss of islet HS and was prevented by inhibiting HS degradation by the endoglycosidase, heparanase. In this study we investigated the distribution of HS and heparan sulfate proteoglycan (HSPG) core proteins in normal human islets, a role for HS in human beta cell viability and the clinical relevance of intraislet HS and HSPG levels, compared to insulin, in human T1D. In normal human islets, HS (identified by 10E4 mAb) co-localized with insulin but not glucagon and correlated with the HSPG core proteins for collagen type XVIII (Col18) and syndecan-1 (Sdc1). Insulin-positive islets of T1D pancreases showed significant loss of HS, Col18 and Sdc1 and heparanase was strongly expressed by islet-infiltrating leukocytes. Human beta cells cultured with HS mimetics showed significantly improved survival and protection against hydrogen peroxideinduced death, suggesting that loss of HS could contribute to beta cell death in T1D. We conclude that HS depletion in beta cells, possibly due to heparanase produced by insulitis leukocytes, may function as an important mechanism in the pathogenesis of human T1D. Our findings raise the possibility that intervention therapy with dual activity HS replacers/ heparanase inhibitors could help to protect the residual beta cell mass in patients recently diagnosed with T1D.: This work was supported by a National Health and Medical Research Council of Australia (NHMRC; https://www.nhmrc.gov.au/)/Juvenile Diabetes Research Foundation (JDRF) Special Program Grant in Type 1 Diabetes (#418138), The Canberra Hospital Private Practice Fund (http:// www.health.act.gov.au/research-publications/research/ppf-major-grants), JDRF nPOD Research Grant (#25-2010-716; http://www.jdrf.org), JDRF Research Grant (#47-2012-746) and NHMRC Project Grant (#1043284

Modified gravity without dark matter

On an empirical level, the most successful alternative to dark matter in bound gravitational systems is the modified Newtonian dynamics, or MOND, proposed by Milgrom. Here I discuss the attempts to formulate MOND as a modification of General Relativity. I begin with a summary of the phenomenological successes of MOND and then discuss the various covariant theories that have been proposed as a basis for the idea. I show why these proposals have led inevitably to a multi-field theory. I describe in some detail TeVeS, the tensor-vector-scalar theory proposed by Bekenstein, and discuss its successes and shortcomings. This lecture is primarily pedagogical and directed to those with some, but not a deep, background in General RelativityComment: 28 pages, 10 figures, lecture given at Third Aegean Summer School, The Invisible Universe: Dark Matter and Dark Energy, minor errors corrected, references update

Shrinking a large dataset to identify variables associated with increased risk of Plasmodium falciparum infection in Western Kenya

Large datasets are often not amenable to analysis using traditional single-step approaches. Here, our general objective was to apply imputation techniques, principal component analysis (PCA), elastic net and generalized linear models to a large dataset in a systematic approach to extract the most meaningful predictors for a health outcome. We extracted predictors for Plasmodium falciparum infection, from a large covariate dataset while facing limited numbers of observations, using data from the People, Animals, and their Zoonoses (PAZ) project to demonstrate these techniques: data collected from 415 homesteads in western Kenya, contained over 1500 variables that describe the health, environment, and social factors of the humans, livestock, and the homesteads in which they reside. The wide, sparse dataset was simplified to 42 predictors of P. falciparum malaria infection and wealth rankings were produced for all homesteads. The 42 predictors make biological sense and are supported by previous studies. This systematic data-mining approach we used would make many large datasets more manageable and informative for decision-making processes and health policy prioritization

Global Search for New Physics with 2.0/fb at CDF

Data collected in Run II of the Fermilab Tevatron are searched for indications of new electroweak-scale physics. Rather than focusing on particular new physics scenarios, CDF data are analyzed for discrepancies with the standard model prediction. A model-independent approach (Vista) considers gross features of the data, and is sensitive to new large cross-section physics. Further sensitivity to new physics is provided by two additional algorithms: a Bump Hunter searches invariant mass distributions for "bumps" that could indicate resonant production of new particles; and the Sleuth procedure scans for data excesses at large summed transverse momentum. This combined global search for new physics in 2.0/fb of ppbar collisions at sqrt(s)=1.96 TeV reveals no indication of physics beyond the standard model.Comment: 8 pages, 7 figures. Final version which appeared in Physical Review D Rapid Communication