Redescription and comparison of a highly fossorial mole, Domninoides mimicus (Insectivora, Talpidae), from the Clarendonian. American Museum novitates ; no. 2667

16 p. : ill. ; 26 cm.Includes bibliographical references (p. 15-16)."The holotype of the species Domninoides mimicus is based on one tooth. Described in the present report is material containing a practically complete dentition and many postcranial elements which definitely belong with the teeth. This species is closely related to Domninoides valentinensis described by Reed (1962), but some of the antemolars in valentinensis are misidentified. The tooth formula for valentinensis should be ?/3? ?/1 ?/3 ?/3 and for mimicus is 2/2 1/- 4/3 3/3. Development of the cingula on the upper and lower molars in mimicus is conspicuous. Because of similar features in postcranial bones, the Clarendonian mole may be as fossorial as Scalopus, probably the most fossorial extant North American mole"--P. [1]

A multivariate study of the family molossidae (mammalia, chiroptera) : morphology, ecology, evolution /

n.s. no.7 (1981

Contributions to mammalogy in honor of Karl F. Koopman. Bulletin of the AMNH ; no. 206

432 p. : ill., maps ; 26 cm.Includes bibliographical references.Karl F. Koopman: a biography and bibliography / David Klingener and Thomas A. Griffiths -- The identity of Phyllostoma planirostre Spix, 1823 (Chiroptera: Sternodermatinae) / Charles O. Handley, Jr. -- The systematic status of Dermanura concolor (Peters, 1865) (Chiroptera: Phyllostomidae), with description of a new genus / Robert D. Owen -- Systematic variation in the megachiropteran tube-nosed bats Nyctimene cyclotis and N. certans / R.L. Peterson -- Examination of monophyly of bats: restriction map of the ribosomal DNA cistron / Robert J. Baker, Rodney L. Honeycutt, and Ronald A. Van Den Bussche -- Morphometrics of the family Emballonuridae / Patricia W. Freeman and Cliff A. Lemen -- Systematics of emballonuroid bats (Chiroptera: Emballonuridae and Rhinopomatidae), based on hyoid morphology / Thomas A. Griffiths and Andrea L. Smith -- Aspects of the morphology of the cochlea in microchiropteran bats: an investigation of character transformation / Michael J. Novacek -- Phylogenetic relationships of the New World bat genus Sturnira (Chiroptera: Phyllostomidae) / Victor Pacheco and Bruce D. Patterson -- Comparative morphology of the glans penis in Molossus, Promops, and Eumops (Chiroptera: Molossidae) / James M. Ryan -- A brief history of Bolivian chiroptology and new records of bats / Sydney Anderson -- An analysis of patterns of distribution and species richness among Philippine fruit bats (Pteropodidae) / Lawrence R. Heaney -- Bats (Mammalia: Chiroptera) from the Togian Islands, Sulawesi, Indonesia / J.E. Hill -- Neotropical Chiroptera from the Pliocene and Pleistocene of Florida / Gary S. Morgan -- Mammals of the Tres Marías Islands / Don E. Wilson -- Tent construction and use by Uroderma bilobatum in coconut palms (Cocos nucifera) in Costa Rica / Robert M. Timm and Susan E. Lewis -- A fossil Myospalax cranium (Rodentia: Muridae) from Shanxi, China, with observations on zokor relationships / Marie A. Lawrence -- Postcranial remains of Xenothrix mcgregori (Primates, Xenotrichidae) and other late Quaternary mammals from Long Mile Cave, Jamaica / R.D.E. MacPhee and John G. Fleagle -- Sulawesi rodents (Muridae: Murinae): morphological and geographical boundaries of species in the Rattus hoffmanni group and a new species from Pulau Peleng / Guy G. Musser and Mary Ellen Holden -- Pseudoryzomys simplex (Rodentia: Muridae) and the significance of Lund's collections from the caves of Lagoa Santa, Brazil / Robert S. Voss and Philip Myers

Comprehensive molecular characterization of urothelial bladder carcinoma

Urothelial carcinoma of the bladder is a common malignancy that causes approximately 150,000 deaths per year worldwide. So far, no molecularly targeted agents have been approved for treatment of the disease. As part of The Cancer Genome Atlas project, we report here an integrated analysis of 131 urothelial carcinomasto provide a comprehensive landscape of molecular alterations. There were statistically significant recurrent mutations in 32 genes, including multiple genes involved in cell-cycle regulation, chromatin regulation, and kinase signalling pathways, as well as 9 genes not previously reported as significantly mutated in any cancer. RNA sequencing revealed four expression subtypes, two of which (papillary-like and basal/squamous-like) were also evident in microRNA sequencing and protein data. Whole-genome and RNA sequencing identified recurrent in-frame activating FGFR3-TACC3 fusions and expression or integration of several viruses (including HPV16) that are associated with gene inactivation. Our analyses identified potential therapeutic targets in 69% of the tumours, including 42% with targets in the phosphatidylinositol-3-OH kinase/AKT/mTOR pathway and 45% with targets (including ERBB2) in the RTK/MAPK pathway. Chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far, indicating the future possibility of targeted therapy for chromatin abnormalitiesclose27