Resource‐based learning strategies: Implications for students and institutions

This paper reports some findings from a project in implementing resource‐based learning in economics, and identifies some implications for students and institutions. These include student responses to a mid‐semester evaluation and the views of the project team. The latter have been informed by action research which sought to recognize students’ individual differences, employ active learning methods and, above all, integrate IT into the curriculum. While innovative strategies are clearly welcomed, students show strong attachment to some traditional methods. Most of those who suggested changes to the range of activities asked for reinstatement of at least some lectures, generally as additions to existing activities. Implications include the need for students and staff to acquire a wide range of new skills, for large‐scale curriculum review if new learning technologies are to be fully integrated, and the need to acknowledge that, given student and staff perceptions of change, the process may be long and costly

Evaluating the Effects of Bisphenols F and S with Respect to Bisphenol A on Primordial Germ Cell Migration in Zebrafish (Danio rerio) Embryos Using Immunofluorescence Microscopy

Primordial Germ Cell (PGC) migration occurs in early embryonic development and is highly conserved across taxa. PGC migration occurs within the first 24 hours post fertilization (hpf) in zebrafish, making the organism an efficient model for observing the migration pathway. Proper PGC migration is necessary for normal gonad development and, in some species, sex determination. Disruption of this process leads to defects in gonad formation and abnormal sex determination and differentiation. Studies show that endocrine-disrupting chemicals such as bisphenol A (BPA) disrupt PGC migration in zebrafish. BPA is an estrogenic compound that has been linked to a variety of human diseases, including various cancers, diabetes, reproductive disorders, obesity, and cardiovascular diseases. It is one of the most widely used synthetic compounds worldwide, as it is used to make polycarbonate plastics. Many studies provide evidence of the harmful effects of BPA on living organisms. In response, manufacturers have started to use replacements such as bisphenol F (BPF) and bisphenol S (BPS). However, due to their structural similarity, it is likely that BPF and BPS are just as harmful to organisms as BPA. In this study, we use antibody staining and immunofluorescence microscopy to confirm that BPA exposure results in abnormal PGC migration in zebrafish embryos, as previously studied, and to illustrate that BPF and BPS exposure results in similar PGC migration defects

Defining Imaginary Audience Scores Via Gender Attributes Versus Biological Gender

Imaginary audience scores for males and females have not demonstrated consistent differences in the literature. In this study, scores on the Imaginary Audience Scale (lAS) and on the Imaginary Audience subscale of the Adolescent Egocentrism-Sociocentrism scale (ABS) were compared to self-rating of gender attributes on the Personality Attributes Questionnaire (PAQ). Results for 64 females and 32 males surveyed at a southeastern university indicate that one\u27s self-rating of gender attributes correlates with imaginary audience scores while biological gender does not. As masculine attribute scores increase, lAS scores and Abiding Self subscale scores decrease. As masculine-feminine attribute scores (traits favored by both sexes) increase, imaginary audience scores increase on all measures

A murine model for developmental dysplasia of the hip: ablation of CX3CR1 affects acetabular morphology and gait.

BACKGROUND: Developmental dysplasia of the hip (DDH) is a debilitating condition whose distinguishing signs include incomplete formation of the acetabulum leading to dislocation of the femur, accelerated wear of the articular cartilage and joint laxity resulting in osteoarthritis. It is a complex disorder having environmental and genetic causes. Existing techniques fail to detect milder forms of DDH in newborns leading to hip osteoarthritis in young adults. A sensitive, specific and cost effective test would allow identification of newborns that could be non-invasively corrected by the use of a Pavlik harness. Previously, we identified a 2.5 MB candidate region on human chromosome 3 by using linkage analysis of a 4 generation, 72 member family. Whole exome sequencing of the DNA of 4 severely affected members revealed a single nucleotide polymorphism variant, rs3732378 co-inherited by all 11 affected family members. This variant causes a threonine to methionine amino acid change in the coding sequence of the CX3CR1 chemokine receptor and is predicted to be harmful to the function of the protein To gain further insight into the function of this mutation we examined the effect of CX3CR1 ablation on the architecture of the mouse acetabulum and on the murine gait. METHODS: The hips of 5 and 8 weeks old wild type and CX3CR1 KO mice were analyzed using micro-CT to measure acetabular diameter and ten additional dimensional parameters. Eight week old mice were gait tested using an inclined treadmill with and without load and then underwent micro-CT analysis. RESULTS: (1) KO mice showed larger a 5-17% larger diameter left acetabula than WT mice at both ages. (2) At 8 weeks the normalized area of space (i.e. size discrepancy) between the femur head and acetabulum is significantly larger [38% (p = 0.001)-21% (p = 0.037)] in the KO mice. (3) At 8 weeks gait analysis of these same mice shows several metrics that are consistent with impairment in the KO but not the WT mice. These deficits are often seen in mice and humans who develop hip OA. CONCLUSION: The effect of CX3CR1 deletion on murine acetabular development provides suggestive evidence of a susceptibility inducing role of the CX3CR1 gene on DDH

The public relations significance to--and impact on--trainees of on-the-job training program of the United States Air Force

Thesis (M.S.)--Boston Universit