Методичні вказівки для проведення практичних занять і організації самостійної роботи з навчальної дисципліни «Управління нерухомим майном» (для студентів 4 курсу денної і заочної форм навчання напряму підготовки 6.080101 – Геодезія, картографія та землеустрій).

Table S2. Week-4 simeprevir pharmacokinetic parameters after administration in (a) Panels 1–3 and (b) Panel 4. (DOCX 15 kb

Additional file 3 of Hepatitis C prevalence in incarcerated settings between 2013–2021: a systematic review and meta-analysis

Additional file 3. A3. Classification system for assessment of study methodologies

Additional file 1 of Hepatitis C prevalence in incarcerated settings between 2013–2021: a systematic review and meta-analysis

Additional file 1. A1. PRISMA 2020 Checklist

Additional file 5 of Hepatitis C prevalence in incarcerated settings between 2013–2021: a systematic review and meta-analysis

Additional file 5. A5. Included prevalence sources with additional risk factors and the prevalence of HIV coinfection, people who inject drugs and male incarcerated individuals (n=92; 36 countries)

Additional file 6 of Hepatitis C prevalence in incarcerated settings between 2013–2021: a systematic review and meta-analysis

Additional file 6. A6. Dissemination of the prevalence hepatitis C antibodies and the prevalence of people who inject drugs (PWID) within the different studies

Histological characteristics in patients admitted to the hospital with alcoholic hepatitis complicated by acute-on-chronic liver failure

Alcoholic hepatitis (AH) is a frequent precipitating event for the development of acute-on-chronic liver failure (ACLF), a syndrome characterised by organ failures due to immune dysfunction. The histological features of this complication are not well characterized. We investigated whether ACLF has specific histological characteristics. Prospective cohort study in consecutive adult patients admitted between 03-2008 and 04-2021 to a tertiary referral centre with suspected AH. Diagnosis of AH was based on clinical presentation and confirmed by transjugular liver biopsy. All biopsies were assessed by a dedicated liver pathologist, blinded for clinical data and outcome. Diagnosis of ACLF was based on EASL-CLIF criteria. Histological and clinical characteristics of patients with and without ACLF at baseline were compared. 184 patients with biopsy-proven AH were enrolled. Median time from hospital admission to transjugular biopsy was 4.5 days (IQR 2-8). At baseline, ACLF was present in 73 patients (39.7%). Out of the 110 patients without ACLF at baseline, 30 (27.3%) developed ACLF within 28 days (median 7.5 days (IQR 2-20)). At baseline, ductular bilirubinostasis (DB) was the only histological feature significantly more frequently present in patients with ACLF compared to patients without ACLF (50.7% vs. 30.6%, p = 0.003). No clear association between histological features and the development of ACLF later on could be demonstrated. In this well-defined cohort of patients with biopsy-proven AH, DB was associated with the presence of ACLF. This finding fits with the pathophysiology of this syndrome, which is characterized by systemic inflammation and an increased risk of infections.</p

Farnesoid X Receptor Activation Attenuates Intestinal Ischemia Reperfusion Injury in Rats - Fig 2

<p>OCA re-activates the FXR-SHP pathway in intestinal IRI as shown by <b>(A)</b> FXR mRNA expression; and <b>(B)</b> FXR downstream target gene SHP expression. mRNA levels were expressed as -ΔΔCt; OCA: obeticholic acid; FXR: farnesoid X receptor; SHP: small heterodimeric partner; IRI: ischemia reperfusion injury, mRNA: messenger ribonucleic acid. **: p<0.01; ***: p<0.001.</p

OCA improves 7-day survival after intestinal IRI.

<p>OCA: obeticholic acid; IRI: ischemia reperfusion injury. n = 10/group, log-rank: p = 0.0128.</p

Pro-Inflammatory Cytokines but Not Endotoxin-Related Parameters Associate with Disease Severity in Patients with NAFLD

<div><p>Intestinal dysbiosis and elevated lipopolysaccharides (LPS) levels have been implicated in the development of obesity, insulin resistance and non-alcoholic steatohepatitis (NASH). In order to determine if LPS levels are elevated in patients with NASH compared to patients with non-alcoholic fatty liver (NAFL) and, if elevated LPS levels correlated with histological severity of non-alcoholic fatty liver disease (NAFLD) we compared LPS, markers of LPS bioactivity and pro-inflammatory cytokines/chemokines in patients undergoing bariatric surgery. At the time of surgery a liver biopsy was taken allowing the stratification into well-delineated subgroups including: No NAFL/NAFL; NASH; NASH with fibrosis and NASH cirrhotics, using the NAFLD Activity Score (NAS). Anthropometric data and plasma were collected for assessment of LPS, lipopolysaccharide binding protein (LBP), soluble CD14 (sCD14), intestinal-type fatty acid binding protein (iFABP), Toll-like receptors 2 and 4 (TLR2, 4) and a panel of cytokines/chemokines. Similar analysis was performed on plasma from a cohort of healthy controls. Our data indicate elevated levels of LPS, LBP, sCD14, iFABP and TLR2,4 in obese patients compared to healthy controls, however, these parameters remained unaltered within patients with limited liver disease (NAFL) compared to NASH/NASH with fibrosis subgroups. Hierarchic cluster analysis using endotoxin-related parameters failed to discriminate between lean controls, NAFLD. While similar cluster analysis implementing inflammation-related parameters clearly distinguished lean controls, NALFD subgroups and NASH cirrhotics. In addition, LPS levels was not associated with disease severity while TNFα, IL8, and CCL3 featured a clear correlation with transaminase levels and the histological severity of NALFD. In conclusion our data indicate a stronger correlation for circulating inflammatory- rather than endotoxin-related parameters in progression of NAFLD and highlights the need for additional larger studies in unravelling further mechanistic insights.</p></div

A schematic representation of the study design

<p>A schematic representation of the study design</p