Procedure to make a regional analysis.

<p>Top and bottom rows show the conversion from a hippocampus segmentation and the six regional mask to a triangulated mesh respectively. The right part of the figure illustrates the registration procedure to map the six regional hippocampus mask to the left and right hippocampus mesh.</p

Left and right hippocampus segmentations in coronal view.

<p>Left: manual segmentation. Middle: FSL-FIRST segmentation. Right: FreeSurfer segmentation.</p

Predicted Jaccard indices for the regional hippocampus for the different segmentation methods.

<p>Predicted Jaccard indices for the regional hippocampus for the different segmentation methods.</p

Predicted Jaccard indices for the whole hippocampus for the different segmentation methods.

<p>Predicted Jaccard indices for the whole hippocampus for the different segmentation methods.</p

Predicted volumes (cm³) for the left hippocampus at time-point BL for all segmentation methods.

<p>Predicted volumes (cm³) for the left hippocampus at time-point BL for all segmentation methods.</p

Regional hippocampus Jaccard indices for all methods and left and right hippocampi.

<p>We combined both time-points, i.e. BL-A–BL-B and M12-A– M12-B, because both time-points by themself gave similar results.</p

Whole hippocampus Jaccard indices for all methods, both time-points and left and right hippocampi to show segmentation reproducibility between BTB scans.

<p>Whole hippocampus Jaccard indices for all methods, both time-points and left and right hippocampi to show segmentation reproducibility between BTB scans.</p

Flowchart of the model selection procedure.

<p>Flowchart of the model selection procedure.</p

Quality control for MRI scan registration.

<p>Results obtained from the residual matrix after the full circle approach. Jaccard error computed for circles defined by <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0166785#pone.0166785.e010" target="_blank">Eq 7</a>.</p

Regional volume comparison for all methods and both time-points.

<p>Left and right hippocampus and scan A and B were grouped together.</p