125 research outputs found

    Beyond ‘ignorance’: using the cultural stereotypes of Americans studying in the UK as a resource for learning and teaching about British culture

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    A course introducing British culture is a standard component of many study abroad programmes running in this country that are aimed at international students who will be spending a limited amount of time in the United Kingdom. However, it is not often acknowledged that such students possess a range of strong pre-conceptions about British culture and society prior to their arrival. Conventional teaching strategies assume student ignorance of the subject. However, an alternative approach which makes us of pre-arrival stereotypes can be more productive in terms of engaging students in active processes of comparative analysis of their new and existing knowledge. A case study of American student stereotypes of the British monarchy is presented and it is suggested that these can be used as the basis for refining student understanding of cultural politics in the United Kingdom. International students, therefore, should not be treated as being culturally ignorant of Britain in the sense of having no knowledge or opinions at all. Rather, it should be understood that they possess a culturally mediated state of subjectivity which I refer to as ‘ignorance’ and that this can become a valuable resource for teaching and learning

    The Case for Intelligent Propulsion Control for Fast Engine Response

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    Damaged aircraft have occasionally had to rely solely on thrust to maneuver as a consequence of losing hydraulic power needed to operate flight control surfaces. The lack of successful landings in these cases inspired research into more effective methods of utilizing propulsion-only control. That research demonstrated that one of the major contributors to the difficulty in landing is the slow response of the engines as compared to using traditional flight control. To address this, research is being conducted into ways of making the engine more responsive under emergency conditions. This can be achieved by relaxing controller limits, adjusting schedules, and/or redesigning the regulators to increase bandwidth. Any of these methods can enable faster response at the potential expense of engine life and increased likelihood of stall. However, an example sensitivity analysis revealed a complex interaction of the limits and the difficulty in predicting the way to achieve the fastest response. The sensitivity analysis was performed on a realistic engine model, and demonstrated that significantly faster engine response can be achieved compared to standard Bill of Material control. However, the example indicates the need for an intelligent approach to controller limit adjustment in order for the potential to be fulfilled

    Abiotically-induced plant morphological changes and host-range expansion in quarantine evaluations of candidate weed biocontrol agents : the case study Conchyloctenia hybrida (Coleoptera: Chrysomelidae)

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    Plant morphological changes mediated by growth conditions are linked to changes in host preference of herbivores. Understanding how these morphological changes influence herbivore feeding is critical in the interpretation of results of host evaluation of candidate weed biocontrol agents in quarantine and improvement of the evaluation system. We determined the effect of plant growth conditions on leaf trichomes and host choice of Conchyloctenia hybrida Boheman, an insect adapted to the removal of trichomes before feeding. The study included four Solanum species: Solanum lichtensteinii Willdenow (natural host of C. hybrida), Solanum mauritianum Scopoli, Solanum melongena L., and Solanum tuberosum L.. Plants were grown in either full sun, shade, a glasshouse, or in a growth-chamber. Plants grown in full sun had a higher leaf trichome density than those in shade or controlled environments. S. mauritianum had the highest trichome density and thickness of trichome layer. In a multiple-choice test using excised leaves, feeding by C. hybrida was higher on Solanum plants grown in the controlled environment as compared with full sun. Trichome removal from leaf surfaces of plants grown in full sun, using adhesive tape, was effective for S. lichtensteinii, S. mauritianum, and S. melongena, but not S. tuberosum. Leaf consumption by C. hybrida increased significantly where manual trichome removal using adhesive tape was effective. Structurally, leaves of S. tuberosum have simple trichomes with basal cells sunken into the mesophyll tissue. When using forceps to remove trichomes of S. tuberosum, mesophyll and vascular tissue remained attached to the trichomes. Generally, the type, density, and mat-thickness of leaf trichomes determined feeding by C. hybrida, but varied with plant species and growth conditions.The South African National Working for Water Programme of the Department of Water Affairshttp://www.entsoc.orgam201

    The molecular, morphological and genetic characterization of glyphosate resistance in Conyza bonariensis from South Africa

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    Six Conyza bonariensis (L.) Cronquist populations were screened in a pot experiment at the University of Pretoria’s Hatfield experimental farm to evaluate and confirm the degree of glyphosate response. Resistance factors ranged from 2.7- to 24.8-fold compared to the most susceptible biotype. Partial sequencing of the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene found no mutation at the Thr102, Ala103 or Pro106 positions. EPSPS mRNA expression levels in glyphosate-resistant biotypes (Swellendam and Piketberg seed sampling sites) were comparable or lower than those in susceptible biotypes (George and Fauresmith sites). Additionally, the highest expression level was reported in the susceptible Fauresmith biotype. These results indicate that glyphosate resistance in the tested resistant biotypes is not caused by target-site mutations and EPSPS gene amplification. Leaf surface characteristics can influence the spread and subsequent absorption of glyphosate. The study established non-significant results in the amount of leaf wax and insufficient mean separations in cuticle thickness and trichome density data. Therefore, the observed differences in response of biotypes to glyphosate treatment could not be attributed conclusively to differences in the leaf morphological characteristics investigated. Results from the inheritance study were consistent with glyphosate resistance being inherited in an incompletely dominant manner when plants were treated with glyphosate herbicide at 900 g ae ha−1 .SUPPLEMENTARY MATERIAL : FIGURE S1. Transmission electron micrographs of outer epidermis cell wall of C. bonariensis showing cuticular membrane. FIGURE S2. Transmission electron micrographs of outer epidermis cell wall of C. bonariensis showing cuticular undulations. FIGURE S3. Scanning electron micrographs of C. bonariensis trichomes on leaf surface (A and B) and on cross section of leaf (C) showing trichomes on both adaxial and abaxial sides. FIGURE S4. Light microscope images of C. bonariensis leaf surface showing numerous trichomes on the adaxial (‘A’) and fewer trichomes on the abaxial (‘B’) leaf surfaces. Figure S5. Melting curves for the EPSPS and Actin genes of C. bonariensis. TABLE S1. qRT-PCR primer sets used in the study.This work was funded by the Organization for Women in Science for the Developing World (OWSD) and the Swedish International Development Cooperation Agency (Sida), Fund Reservation numbers 3240266448 and 3240278002, National Research Foundation (NRF) South Africa, Grant Unique Number 88750, and Monsanto South Africa under Project 07458, Herbicide crop resistance.the Organization for Women in Science for the Developing World (OWSD), the Swedish International Development Cooperation Agency (Sida), National Research Foundation (NRF) South Africa and Monsanto South Africa.https://www.mdpi.com/journal/plantsdm2022Forestry and Agricultural Biotechnology Institute (FABI)Plant Production and Soil Scienc

    Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

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    A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

    Quality indicators for patients with traumatic brain injury in European intensive care units

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    Background: The aim of this study is to validate a previously published consensus-based quality indicator set for the management of patients with traumatic brain injury (TBI) at intensive care units (ICUs) in Europe and to study its potential for quality measur

    Changing care pathways and between-center practice variations in intensive care for traumatic brain injury across Europe

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    Purpose: To describe ICU stay, selected management aspects, and outcome of Intensive Care Unit (ICU) patients with traumatic brain injury (TBI) in Europe, and to quantify variation across centers. Methods: This is a prospective observational multicenter study conducted across 18 countries in Europe and Israel. Admission characteristics, clinical data, and outcome were described at patient- and center levels. Between-center variation in the total ICU population was quantified with the median odds ratio (MOR), with correction for case-mix and random variation between centers. Results: A total of 2138 patients were admitted to the ICU, with median age of 49 years; 36% of which were mild TBI (Glasgow Coma Scale; GCS 13–15). Within, 72 h 636 (30%) were discharged and 128 (6%) died. Early deaths and long-stay patients (> 72 h) had more severe injuries based on the GCS and neuroimaging characteristics, compared with short-stay patients. Long-stay patients received more monitoring and were treated at higher intensity, and experienced worse 6-month outcome compared to short-stay patients. Between-center variations were prominent in the proportion of short-stay patients (MOR = 2.3, p < 0.001), use of intracranial pressure (ICP) monitoring (MOR = 2.5, p < 0.001) and aggressive treatme

    Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3b

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    We search for gravitational-wave signals associated with gamma-ray bursts (GRBs) detected by the Fermi and Swift satellites during the second half of the third observing run of Advanced LIGO and Advanced Virgo (2019 November 1 15:00 UTC-2020 March 27 17:00 UTC). We conduct two independent searches: A generic gravitational-wave transients search to analyze 86 GRBs and an analysis to target binary mergers with at least one neutron star as short GRB progenitors for 17 events. We find no significant evidence for gravitational-wave signals associated with any of these GRBs. A weighted binomial test of the combined results finds no evidence for subthreshold gravitational-wave signals associated with this GRB ensemble either. We use several source types and signal morphologies during the searches, resulting in lower bounds on the estimated distance to each GRB. Finally, we constrain the population of low-luminosity short GRBs using results from the first to the third observing runs of Advanced LIGO and Advanced Virgo. The resulting population is in accordance with the local binary neutron star merger rate. © 2022. The Author(s). Published by the American Astronomical Society
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