7 research outputs found

    MYC expression in SCLC cell lines by IHC.

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    <p>Representative MYC IHC staining patterns are shown: <i>A</i>, negative (H196 / H-score 0); <i>B</i>, low MYC (H1963 / H-score 55); <i>C</i>, high MYC (H146 / H-score 140); and <i>D</i>, high MYC (N417 / H-score 230). <i>E</i>, summary of MYC IHC staining by positive cell ratio. The red star indicates cells with <i>MYC</i> gene amplification.</p

    Establishment of cisplatin treated cells and the sensitivity to Pladienolide B.

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    <p><i>A</i>, efficacy of cisplatin in SW1271 and H1048 parental cells. <i>B</i>, efficacy of Pladienolide B in parental cells and cisplatin-treated cells. Percent growth was calculated relative to DMSO-treated control.</p

    Efficacy of a spliceosome inhibitor, Pladienolide B, on SCLC cell lines.

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    <p>Cells were treated with Pladienolide B for 72 hours and the percent growth was calculated relative to the DMSO-treated control. <i>A</i>, cell lines were classified based on the IHC MYC expression status. <i>B</i>, cell lines were classified based on the presence / absence of a previous chemotherapy at the time of cell line establishment.</p
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