Genetic risk score and the risk of TPOAb-positivity.

<p>GRS, genetic risk score (based on rs11675434, rs653178, rs10944479, rs1230666, rs2010099).</p>a<p>Adjusted for age and gender</p

Population characteristics and serum TPOAb, TSH, and FT4 level measurements specifications.

<p>Population characteristics and serum TPOAb, TSH, and FT4 level measurements specifications.</p

Newly identified loci associated with TPOAb-positivity and/or serum TPOAb levels reaching genome wide significance.

<p>Chr., chromosome</p>a<p>Risk allele frequency: Weighted mean frequency of the risk allele across all included cohorts.</p>b<p>Adjusted for age and gender</p>c<p>Expressed in sd of natural logarithm transformed serum TPOAb level, adjusted for age and gender</p

Newly identified TPOAb associated loci and the risk of thyroid disease in stage 1 and 2 populations.

<p>All analyses adjusted for age and gender.</p><p><i>ATXN2</i>-rs653178 is in high LD with <i>SH2B3-</i> rs3184504</p><p><i>MAGI3-</i>rs1230666 is in high LD with <i>PTPN22-</i>rs2476601</p

Newly identified TPOAb associated loci, genetic risk scores and the risk of goiter.

<p>GRS, genetic risk score (based on rs11675434, rs653178, rs10944479, rs1230666, rs2010099).</p>a<p>Adjusted for age, gender, and body surface area.</p><p><i>ATXN2</i>-rs653178 is in high LD with <i>SH2B3</i>-rs3184504.</p><p><i>MAGI3</i>-rs1230666 is in high LD with <i>PTPN22</i>-rs24756601.</p