Haben die Konzentrationen von Interleukin 6, Procalcitonin und CRP bei Intensivpatienten während des ersten Fieberanstieges eine prognostische Bedeutung?

Serum levels of interleukin 6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) were measured in 38 critically ill patients immediately after an increase in body temperature above 38.3 degrees C. Ten healthy controls were also included for comparison. The onset of fever was accompanied by elevated circulating levels of all the 3 markers in comparison to healthy control subjects. However, only IL-6 levels were significantly higher (p<0.05) in nonsurvivors compared with survivors. Sensitivity, specificity, positive, and negative predictive values for survival were higher for IL-6 in comparison to levels of PCT and CRP. Areas under receiver characteristic operating curves revealed the highest area under the curve for IL-6 compared to PCT and CRP. These data suggest that IL-6 rather than PCT or CRP may be an early predictor of prognosis and mortality in patients with the onset of fever

Организация работ по охране труда и оценка рисков работников нефтегазодобывающего предприятия

Несмотря на усовершенствование технологических процессов и вводимые меры по обеспечению безопасности труда, на предприятиях существует тенденция к снижению себестоимости продукции. В связи с этим увеличивается вероятность возникновения производственных рисков на промышленных предприятиях, которые рассмотрены в данной работе на примере нефтегазодобывающего управления "Федоровскнефть".Despite the improvement of technological processes and the introduction of measures to ensure labor safety, there is a tendency at enterprises to reduce the cost of production. In this connection, the probability of occurrence of industrial risks in industrial enterprises is increased, which are considered in this work by the example of oil and gas production department "Fedorovskneft"

Proinflammatory genotype is associated with the frailty phenotype in the English Longitudinal Study of Ageing

Background: Frailty is a state of increased vulnerability to poor resolution of homeostasis after a stressor event, which increases the risk of adverse outcomes including falls, disability and death. The underlying pathophysiological pathways of frailty are not known but the hypothalamic–pituitary–adrenal axis and heightened chronic systemic inflammation appear to be major contributors. Methods: We used the English Longitudinal Study of Ageing dataset of 3160 individuals over the age of 50 and assessed their frailty status according to the Fried-criteria. We selected single nucleotide polymorphisms in genes involved in the steroid hormone or inflammatory pathways and performed linear association analysis using age and sex as covariates. To support the biological plausibility of any genetic associations, we selected biomarker levels for further analyses to act as potential endophenotypes of our chosen genetic loci. Results: The strongest association with frailty was observed in the Tumor Necrosis Factor (TNF) (rs1800629, P = 0.001198, β = 0.0894) and the Protein Tyrosine Phosphatase, Receptor type, J (PTPRJ) (rs1566729, P = 0.001372, β = 0.09397) genes. Rs1800629 was significantly associated with decreased levels of high-density lipoprotein (HDL) (P = 0.00949) and cholesterol levels (P = 0.00315), whereas rs1566729 was associated with increased levels of HDL (P = 0.01943). After correcting for multiple testing none of the associations remained significant. Conclusions: We provide potential evidence for the involvement of a multifunctional proinflammatory cytokine gene (TNF) in the frailty phenotype. The implication of this gene is further supported by association with the endophenotype biomarker results

Spin fluctuation and single-ion effects in dilute UPt3

Spin fluctuation and single-ion effects in dilute UPt3 / G. Fraunberger ; M. Baldus ; G. R. Stewart. - In: Physical review. B. 47. 1993. S. 3204-320

Specific-Heat Measurements on UBe₁₃ under Uniaxial Pressure

We have investigated the superconducting ground state of a high-quality UBe13 single crystal under uniaxial pressure along the [110] axis. Uniaxial pressure is expected to break the cubic symmetry and, perhaps, to remove orbital degeneracies associated with a multidimensional order parameter. However, our specific-heat measurements reveal no splitting of the superconducting transition at T(c) up to 6.8 kbar. Both T(c) (congruent-to 0.72 K) and the Sommerfeld coefficient gamma(congruent-to 1 J/k2 mole) decrease with increasing pressure, but the slopes disagree with the 1/3 rule of the hydrostatic values, as determined for polycrystalline samples

Cytokine production precedes the expansion of CD14+CD16+ monocytes in human sepsis: a case report of a patient with self-induced septicemia

We describe a patient with self-induced disease who presented with repeated urinary tract infection and sepsis due to intravesical and intravenous injection of feces. Sepsis occurred repeatedly such that the patient exhibited 10 bouts of fever > 40 degrees C in a single month. This bacterial challenge led to massive activation of the monocyte system with high levels of TNF-alpha, IL-6, and monocyte colony-stimulating factor (M-CSF). This cytokine response was followed by strong expansion of the novel CD14+CD16+ monocyte subset. These results suggest that cytokines induce the development of CD14+CD16+ cells in human septicemia and that CD14+CD16+ cells may serve as indicator for previous bouts of excessive inflammation